Ec2la - Moligand™, ≥98%(HPLC) , Allosteric modulator of CB 2 receptor, CAS No.2244579-87-9, Allosteric modulator of CB 2 receptor

CAS: 2244579-87-9 Cat. No.: E288545 Summenformel: C₂₁H₂₄BrFN₂O₂ Molekulargewicht: 435.33

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide | CB2R PAM

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyme

N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide | CB2R PAM

Spezifikationen & Reinheit

Moligand™, ≥98%(HPLC)

Biochemische und physiologische Mechanismen

CB2receptor positive allosteric modulator. EnhancesCP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ALLOSTERIC MODULATOR

Mechanismus der Wirkung

Allosteric modulator of CB 2 receptor

Reinheit

≥98%(HPLC)

Namen und Kennungen

• Pubchem Sid: 504773499
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773499
• Kanonisches Lächeln: CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3
• IUPAC Name: N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide
• InChIKey: NSGDYZCDUPSTQT-UHFFFAOYSA-N
• INCHI: 1S/C21H24BrFN2O2/c1-14-18(22)13-25(12-15-8-10-17(23)11-9-15)21(27)19(14)24-20(26)16-6-4-2-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,24,26)
• Isomere SMILES: CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3
• Molekulargewicht: 435.33
• Reaxy-Rn: 33991973
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33991973&ln=

Zugehörige Ziele (menschlich)

CNR2 Tchem Cannabinoid receptor 2 (2 Activities)

Discover Target: CNR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

Discover Target: CNR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)

Discover Target: CNR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 8.71, Max Conc. mM: 20
• Molekulargewicht: 435.300 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 434.101 Da
• Monoisotopic Mass: 434.101 Da
• Topological Polar Surface Area: 49.400 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 630.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1