≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
FAPI-46 is a quinoline-based fibroblast activation protein (FAP) -targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers
In Vitro
FAPI-46 (1-24 h) robustly binds to human FAP in human FAP-expressing HT-1080 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:fibroblast activation protein (FAP)
| Kanonisches Lächeln | CN(CCCN1CCN(CC1)C(=O)CN2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O)C3=CC4=C(C=CN=C4C=C3)C(=O)NCC(=O)N5CC(CC5C#N)(F)F |
|---|---|
| IUPAC Name | 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]-methylamino]propyl]piperazin-1-yl]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid |
| InChIKey | SDBGUEFOSXNKBX-HKBQPEDESA-N |
| INCHI | 1S/C41H57F2N11O9/c1-47(30-3-4-34-33(21-30)32(5-6-45-34)40(63)46-24-35(55)54-29-41(42,43)22-31(54)23-44)7-2-8-48-17-19-53(20-18-48)36(56)25-49-9-11-50(26-37(57)58)13-15-52(28-39(61)62)16-14-51(12-10-49)27-38(59)60/h3-6,21,31H,2,7-20,22,24-29H2,1H3,(H,46,63)(H,57,58)(H,59,60)(H,61,62)/t31-/m0/s1 |
| Isomere SMILES | CN(CCCN1CCN(CC1)C(=O)CN2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O)C3=CC4=C(C=CN=C4C=C3)C(=O)NCC(=O)N5CC(C[C@H]5C#N)(F)F |
| Alternative CAS-Nummer | 2374782-04-2 |
| PubChem CID | 139400499 |
| MeSH-Eintrag | (68Ga)-FAPI-46;68Ga-FAPI-46;FAPI-46 |
| Molekulargewicht | 885.96 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Klasse | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | N-acyl-alpha amino acids and derivatives |
| Alternative Parents | Quinoline carboxamides Alpha amino acid amides Aminoquinolines and derivatives Alpha amino acids Tricarboxylic acids and derivatives Pyridinecarboxylic acids and derivatives N-acylpyrrolidines Dialkylarylamines N-alkylpiperazines Methylpyridines Hydroxypyridines N-acyl amines Benzenoids Tertiary carboxylic acid amides Secondary ketimines Heteroaromatic compounds Trialkylamines Amino acids Propargyl-type 1,3-dipolar organic compounds Nitriles Enamines Carboxylic acids Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Quinoline-4-carboxamide - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Aminoquinoline - Quinoline - Alpha-amino acid - Tricarboxylic acid or derivatives - Pyridine carboxylic acid or derivatives - Dialkylarylamine - Tertiary aliphatic/aromatic amine - N-acylpyrrolidine - Methylpyridine - Hydroxypyridine - N-alkylpiperazine - Benzenoid - Pyridine - Piperazine - N-acyl-amine - 1,4-diazinane - Heteroaromatic compound - Tertiary carboxylic acid amide - Secondary ketimine - Pyrrolidine - Amino acid - Tertiary aliphatic amine - Tertiary amine - Ketimine - Carboxamide group - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Nitrile - Carbonitrile - Enamine - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Imine - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound |
| Beschreibung | This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom. |
| External Descriptors | Not available |
| Löslichkeit | H2O : 100 mg/mL (112.87 mM; Need ultrasonic) DMSO : 100 mg/mL (112.87 mM; Need ultrasonic) |
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