Insulin Resistance

Diabetes mellitus is a chronic metabolic disease caused by insufficient insulin secretion, insulin resistance, or a combination of both. Natural products possess diverse structural classes and multiple biological targets and can be used in studies of glucose-metabolism regulation, bioactive ...

Metabolic disorders involve multiple abnormalities, including insulin resistance, dysregulated glucose and lipid metabolism, chronic inflammation, and oxidative stress. Natural products possess diverse structural classes and molecular targets and can improve metabolic homeostasis by regulating ...

Metabolic dysfunction-associated steatohepatitis is jointly driven by hepatic fat accumulation, lipotoxicity, insulin resistance, inflammation, and fibrosis. Targeting lipid metabolism, nuclear receptors, incretin pathways, and FGF signaling has become a major direction in drug development.

Metabolic syndrome is not a single abnormality in blood glucose or blood lipids, but the combined result of insulin resistance, adipose tissue endocrine dysfunction, chronic low-grade inflammation, hepatic lipid metabolism disorder, and cardiometabolic risk. Detection strategies should place ...