Nitrogen-containing heterocycles

Triazines are a class of six-membered aromatic nitrogen-containing heterocycles formed by replacing three carbon atoms in a benzene ring with three nitrogen atoms. Accordingly, they exist as three regioisomers: 1,2,3-triazine, 1,2,4-triazine, and 1,3,5-triazine.

Quinazoline is a fused, aromatic nitrogen-containing heterocyclic core scaffold. In research and medicinal chemistry, compounds derived from this core are commonly referred to collectively as “quinazoline derivatives.” Structurally, quinazoline can be understood as a bicyclic system formed ...

Modern synthesis increasingly faces the same hard requirement set: use less Pd, deal with “less reactive” substrates (typified by aryl chlorides), and still maintain yield, impurity profile, and batch-to-batch reproducibility upon scale-up. When the substrate is harder to activate (Ar–Cl), ...

In clinical diagnostics and life-science testing, many analytes (hormones, tumor markers, infection-related proteins, etc.) exist at very low concentrations. A detection system must satisfy three requirements at once: high sensitivity (detectable at low concentration), high speed (automation and ...