1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
The C(sp³)–H bonds of inert alkanes generally have high bond dissociation energies, making their direct conversion into carbon-centered radicals capable of participating in bond-forming reactions difficult. Photocatalytic C(sp³)–H functionalization therefore often relies on photocatalysts ...
In 2024, Reber and colleagues from the process research and development team at the Swiss biopharmaceutical company Idorsia Pharmaceuticals Ltd. (Idorsia) reported the kilogram-scale synthesis of ACT-1014-6470, an antagonist of complement C5a receptor 1 (C5aR1), in Organic Process Research & ...
Naphthoquinones are formed by fusion of a quinonoid six-membered ring containing two carbonyl groups with a benzene ring. This fused structure gives the molecule both a quinonoid reactive region and a benzenoid ring region, which influence each other through a continuous π system. The quinonoid ...
Chiral cyclopropanecarboxylic acids are important structural units in organic synthesis and medicinal chemistry. Cyclopropanes possess substantial ring strain and rigidity, which can restrict the spatial orientation of substituents and are therefore frequently used to construct molecules with ...
Aminotransferases are key enzymes in amino acid metabolism that redistribute amino groups and carbon skeletons through pyridoxal 5′-phosphate (PLP)-dependent transamination reactions. Members such as ALT, AST, and BCAT connect alanine, aspartate, and branched-chain amino acid metabolism, ...
The Forkhead box (FOX) family comprises transcription factors characterized by a conserved Forkhead DNA-binding domain. These proteins are extensively involved in embryonic development, tissue differentiation, metabolic homeostasis, cell proliferation, stress responses, and immune regulation. ...
Density-gradient centrifugation establishes media with different densities, allowing cells, organelles, membranous particles, macromolecular complexes, and nucleic acids to be fractionated according to their sedimentation behavior or buoyant density. Colloidal silica media, polysucrose media, ...
Amino heteroarenes, including aminopyridines, aminopyrroles, aminofurans, and aminothiophenes, are widely found in pharmaceuticals and bioactive compounds. Although numerous methods are now available for C–N bond formation, a practical challenge in the synthesis of these structures often lies ...
Coenzyme A (CoA) is an essential intracellular acyl-group carrier. By combining with different acyl groups, CoA forms various acyl-CoAs that connect carbohydrate, lipid, and amino acid metabolism. Through carbon-flux distribution, CoA-pool balance, and protein acylation, CoA and its derivatives ...