1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
The 3C-like protease (3CL^pro), also known as the main protease (M^pro), is responsible for cleaving pp1a and pp1ab at 11 sites, thereby contributing to the release of the nonstructural proteins required for viral replication. Inhibition of 3CL^pro reduces the production of mature nonstructural ...
Uric acid is the major end product of purine catabolism in humans and exists primarily as free uric acid or urate in blood, urine, and tissues. Uric acid quantification is a commonly used technique in clinical biochemical analysis and metabolic research and is widely applied in hyperuricemia ...
Non-small cell lung cancer exhibits substantial histological and molecular heterogeneity. Alterations involving EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, HER2, and other oncogenic drivers can continuously activate tumor-cell proliferation and survival signaling and generate molecular subtypes with ...
Protein kinases and phosphatases jointly regulate the phosphorylation states of proteins, thereby affecting cellular signaling, metabolism, proliferation, and stress responses. Phosphorylation or dephosphorylation does not directly equate to protein activation or inactivation, and its effect ...
The synthetic design of morpholine-containing compounds cannot be based solely on the fact that the target molecule “contains a morpholine ring.” In a given structure, the morpholine unit may be connected to the main scaffold through the ring nitrogen, the terminus of a side chain, or a ring ...
Piperidine is a saturated six-membered nitrogen-containing ring commonly found in pharmaceutical molecules, alkaloids, and synthetic intermediates. Traditional synthetic routes generally install substituents before ring formation, whereas C–H functionalization can directly use an ...
Tranexamic acid, abbreviated as TXA, also known as aminomethylcyclohexanecarboxylic acid, is a synthetic lysine analogue originally used in antifibrinolytic therapy. Its classical medical action is to competitively bind to the lysine-binding sites on plasminogen/plasmin, thereby reducing plasmin ...
Microbial culture is a fundamental technique that enables microorganisms to grow, be isolated, or produce specific metabolites in vitro by controlling nutrient composition, pH, osmotic pressure, oxygen supply, temperature, and other conditions. Culture-medium composition directly affects strain ...
Deprotonation is an important approach to carbon–hydrogen bond functionalization. After a base removes a proton from a carbon atom, a carbanion or organometallic species can be formed, which can subsequently react with an electrophile to construct a new carbon–carbon or carbon–heteroatom bond.