1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious problem in current tumor therapy. A team of researchers at MD Anderson Cancer Center published a study in the Journal of Medicinal Chemistry on the DLK inhibitor IACS-52825, which showed that the drug significantly ameliorated ...
Recently, Ukrainian scientists reported a breakthrough research result in the journal Angewandte Chemie International Edition.They synthesized a new ring isomer, 3-azabicyclo[3.1.1]heptanes(aza-BCHP for short), by the reduction of spiroepoxetane, and Aladdin Scientific is available as a related ...
In the process of developing new drugs, chiral dihydroazaindolecarboxylic acid (R)-1 is in great demand as a key starting material for the synthesis of active pharmaceutical ingredients (APIs). However, the traditional synthesis method, chiral supercritical fluid chromatographic separation, is ...
In drug design, halogen bond interactions are often applied, but their conformation is mainly limited to the aromatic plane. Recently, Professor Franziska Zimmermann's team at the University of Tübingen in Germany published a paper in the journal J. Med. Chem., introducing the unique advantages ...
Benzene ring is a key structural element in chemistry, as the most commonly used ring in natural products, bioactive compounds and drugs, it is difficult to find suitable replacements. Recently, a research team in Kiev, Ukraine, found that an organic molecule called heptane spiral [3.3] can be ...
Spirocyclic compounds are not new as an important area of drug research. In recent years, the demand for compounds with high stereospecificity and spatial structure has been increasing, and the introduction of spirocyclic scaffolds has become an innovative strategy in drug design. Spirocyclic ...
Photoaffinity probes (PAPs) are nowadays the "magic weapons" in drug discovery and development, which can unlock the binding mechanism of drugs and target proteins and find new drug action sites. Among them, diazirine-based photoactivation reagents are the most widely used.
Connecting multiple peptide fragments to form an extended peptide chain is referred to as ligation. Click chemistry offers a convenient method for creating peptide-peptide linkages. By introducing an alkyne group to one peptide fragment and an N-terminal azide moiety to another, a triazole ...
Many drug molecules contain a benzene ring structure, but benzene rings can also cause some metabolic problems. In order to minimize this "side effect", scientists have explored a number of alternative structures to the benzene ring. Recently, a team of researchers at Emory University in the USA ...