GSK126 - Moligand™, ≥98% , Histone-lysine N-methyltransferase EZH2 inhibitor, CAS No.1346574-57-9, Histone-lysine N-methyltransferase EZH2 inhibitor

Name: GSK126 - Moligand™, ≥98% , Histone-lysine N-methyltransferase EZH2 inhibitor, CAS No.1346574-57-9, Histone-lysine N-methyltransferase EZH2 inhibitor
SKU: G124898
Availability: InStock

CAS: 1346574-57-9 Cat. No.: G124898 Summenformel: C₃₁H₃₈N₆O₂ Molekulargewicht: 526.67

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GSK126 - Moligand™, ≥98% CAS No(1346574-57-9) by Aladdin Scientific

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GRADE & PURITY Moligand™ ? ≥98%

Synonyms

NSC780041 | NSC-780041 | Q27077865 | BDBM50017293 | N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide | SMR004701327 | 1H-Indole-4-carboxamide, N-((1,2-dihydro

Storage

Lagerung bei -20°C

Shipped In

Eistruhe + Eispads

Übersicht Specifications Produkteigenschaften Namen und Kennungen Documentation Advanced Data Taxonomic Classification 3D-Struktur Zugehörige Ziele (menschlich) Zugehörige Ziele (nicht menschlich) Wirkungsmechanismen Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm) Chemische und physikalische Eigenschaften FAQs und Artikel Lösungsrechner Bewertungen

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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Lagerung bei -20°C Ships Eistruhe + Eispads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Übersicht

GSK126 ist ein potenter, hochselektiver, kompetitiver niedermolekularer S-Adenosylmethionin-Inhibitor der EZH2-Methyltransferase mit einem Ki-Wert von 0,5 nM.

Specifications

Synonyme

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

Beschreibung:IC50-Wert: 0,5nM (Ki)GSK126, ein potenter, hochselektiver, S-Adenosyl-Methionin-kompetitiver, niedermolekularer Inhibitor der EZH2-Methyltransferase-Aktivität, senkt die globalen H3K27me3-Werte und reaktiviert stillgelegte PRC2-Zielgene. GSK1

Storage

Lagerung bei -20°C

Verschickt in

Eistruhe + Eispads

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Histone-lysine N-methyltransferase EZH2 inhibitor

Hinweis

Weitere Informationen finden Sie im SDB. Benötigen Sie weitere Ratschläge zu Löslichkeit, Verwendung und Handhabung? Besuchen Sie unsere Seite mit den häufig gestellten Fragen (FAQ) für weitere Informationen.

Reinheit

≥98%

Produkteigenschaften

ALogP	3.9

Namen und Kennungen

Pubchem Sid	528764671
Kanonisches Lächeln	CCC(C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
IUPAC Name	1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide
InChIKey	FKSFKBQGSFSOSM-QFIPXVFZSA-N
INCHI	1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1
Isomere SMILES	CC[C@H](C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
Molekulargewicht	526.67
Reaxy-Rn	21957292
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21957292&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Klasse Diazinanes
    - Subclass Piperazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Klasse	Diazinanes
Subclass	Piperazines
Intermediate Tree Nodes	Not available
Direct Parent	Pyridinylpiperazines
Alternative Parents	N-arylpiperazines Indolecarboxamides and derivatives 3-methylindoles N-alkylindoles Dialkylarylamines Pyridinones Aminopyridines and derivatives Methylpyridines Dihydropyridines Substituted pyrroles Imidolactams Benzenoids Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Lactams Azacyclic compounds Dialkylamines Organopnictogen compounds Organic oxides Hydrocarbon derivatives Organooxygen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyridinylpiperazine - N-arylpiperazine - Indolecarboxylic acid derivative - Indolecarboxamide derivative - 3-alkylindole - N-alkylindole - 3-methylindole - Indole - Indole or derivatives - Dialkylarylamine - Aminopyridine - Dihydropyridine - Methylpyridine - Pyridinone - Hydropyridine - Imidolactam - Benzenoid - Substituted pyrrole - Pyridine - Heteroaromatic compound - Pyrrole - Secondary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Lactam - Secondary amine - Carboxylic acid derivative - Secondary aliphatic amine - Azacycle - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Hydrocarbon derivative - Amine - Aromatic heteropolycyclic compound
Beschreibung	This compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D-Struktur

Zugehörige Ziele (menschlich)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (14 Activities)

Discover Target: EZH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Daudi (625 Activities)

Lot Number	Certificate Type	Datum	Artikel
L2420415	Certificate of Analysis	Sep 21, 2026	G124898
H1518099	Certificate of Analysis	Sep 07, 2026	G124898

Löslichkeit	25°C: DMSO
Molekulargewicht	526.700 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	526.306 Da
Monoisotopic Mass	526.306 Da
Topological Polar Surface Area	91.300 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	972.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

GSK126 - Moligand™, ≥98% , Histone-lysine N-methyltransferase EZH2 inhibitor, CAS No.1346574-57-9, Histone-lysine N-methyltransferase EZH2 inhibitor

Why this grade

Storage & shipping

Quality documents

Literature proof

Übersicht

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Kundenbewertungen

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