1,4-Dichloronaphthalene: Properties, Safety & Lab Use Guide

1,4-Dichloronaphthalene is a halogenated polycyclic aromatic compound widely used as a synthetic intermediate and reference standard in organic chemistry research.

Chemical Name

1,4-Dichloronaphthalene

Molecular Formula

C₁₀H₆Cl₂

Molecular Weight

197.06 g/mol

CAS Number

1825-31-6

Appearance

White to off-white crystalline solid

SKU

D693604

Supplier

Aladdin Scientific

Chemical Identity and Physicochemical Properties

1,4-Dichloronaphthalene (CAS 1825-31-6) is a dichloro-substituted derivative of naphthalene in which chlorine atoms occupy the 1- and 4-positions of the bicyclic aromatic ring system. Its molecular formula is C₁₀H₆Cl₂ with a molecular weight of approximately 197.06 g/mol.

The compound typically presents as a white to off-white crystalline solid at room temperature. As a halogenated polycyclic aromatic hydrocarbon (PAH), it exhibits characteristic aromatic stability combined with the reactivity imparted by the two electronegative chlorine substituents. It is generally sparingly soluble in water but soluble in common organic solvents such as dichloromethane, chloroform, ethyl acetate, and tetrahydrofuran.

Note: Specific melting point, boiling point, density, and flash point values should be verified against the current Aladdin Scientific certificate of analysis (CoA) for lot D693604, as these may vary by grade and purity.

Laboratory Applications and Uses

1,4-Dichloronaphthalene serves several roles in chemical research and development:

• Organic Synthesis Intermediate: The two C–Cl bonds provide handles for nucleophilic aromatic substitution, transition-metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Kumada couplings), and halogen-exchange reactions, enabling construction of more complex naphthalene-based architectures.
• Material Science Research: Halogenated naphthalenes are used as building blocks for organic electronic materials, including precursors to semiconducting polymers and liquid crystal components.
• Reference Standard: The compound may serve as an analytical reference or calibration standard in environmental monitoring of halogenated aromatic contaminants.
• Biological and Environmental Studies: As a structural analog of polychlorinated naphthalenes (PCNs), it is employed in mechanistic studies examining aryl hydrocarbon receptor (AhR) interactions and environmental fate of halogenated aromatics.

Researchers should verify suitability of the specific purity grade (D693604) for their intended application by consulting the product specification sheet.

Safe Handling, Storage, and Disposal

Hazard Overview: 1,4-Dichloronaphthalene is a halogenated aromatic compound that should be treated as a potential irritant and environmental hazard. Users must consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before use.

Personal Protective Equipment (PPE):

• Wear chemical-resistant gloves (e.g., nitrile or neoprene) at all times when handling.
• Use safety goggles or a face shield to protect against dust and vapour contact with eyes.
• A laboratory coat and closed-toe shoes are mandatory.
• Handle in a well-ventilated fume hood to minimise inhalation of dust or vapours.

Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area away from heat sources, ignition sources, and incompatible materials (strong oxidisers, strong bases). Follow the temperature range specified on the product label and CoA.

Disposal: Dispose of 1,4-Dichloronaphthalene and contaminated materials as halogenated organic waste in accordance with local, regional, and national regulations. Do not pour down the drain or discard with general laboratory waste.

Spill Response: Contain spills using inert absorbent material, collect into a suitable labelled waste container, and ventilate the affected area. Avoid generating dust.

Quality, Purity, and Ordering Information

Aladdin Scientific supplies 1,4-Dichloronaphthalene under SKU D693604. Researchers and procurement staff should request the Certificate of Analysis (CoA) for the specific lot upon ordering to confirm:

• Purity (%) determined by GC or HPLC
• Appearance and physical state
• Residual solvent or moisture content where applicable
• Analytical data supporting identity (NMR, MS, or IR)

For bulk quantities, custom purity grades, or special packaging requirements, contact Aladdin Scientific's technical sales team. Ensure that the grade purchased meets the regulatory and quality standards required for your specific research application (e.g., synthesis vs. analytical reference vs. biological assay).

Lab managers should verify current stock availability and lead times through the Aladdin Scientific online catalogue or by contacting customer service directly.

Frequently asked questions

What is 1,4-Dichloronaphthalene used for in the laboratory?

1,4-Dichloronaphthalene is primarily used as an organic synthesis intermediate in cross-coupling reactions and nucleophilic aromatic substitutions to build complex naphthalene-based molecules. It also serves as an analytical reference standard and as a model compound in environmental and biological studies of halogenated aromatics.

How should 1,4-Dichloronaphthalene be stored to maintain stability?

Store 1,4-Dichloronaphthalene in a tightly sealed container in a cool, dry, well-ventilated area away from heat, light, and incompatible substances such as strong oxidisers and strong bases. Always follow the specific storage conditions stated on the Aladdin Scientific product label and Certificate of Analysis for lot D693604.

What personal protective equipment is required when handling 1,4-Dichloronaphthalene?

When handling 1,4-Dichloronaphthalene, wear chemical-resistant gloves (nitrile or neoprene), safety goggles or a face shield, a laboratory coat, and closed-toe shoes. All operations should be conducted in a well-ventilated fume hood. Consult the full SDS from Aladdin Scientific for comprehensive hazard and first-aid information.

How do I confirm the purity of Aladdin Scientific's 1,4-Dichloronaphthalene (D693604)?

Request the Certificate of Analysis (CoA) for the specific production lot from Aladdin Scientific at the time of ordering. The CoA will document purity by GC or HPLC, appearance, and spectral identification data. Contact Aladdin Scientific customer service if you require additional analytical documentation.

References

1. Aladdin Scientific. Product page: 1,4-Dichloronaphthalene, SKU D693604. Aladdin Scientific Corporation.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 4th ed. Wiley-Interscience, 1992. [General reference for nucleophilic aromatic substitution and cross-coupling reactions of aryl halides.]
3. Falandysz, J. Polychlorinated naphthalenes: an environmental update. Environmental Pollution, 1998. [Background on polychlorinated naphthalene environmental chemistry relevant to dichloronaphthalene analogs.]

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.