Magnesium stearate - PharmPure™, USP, Ph.Eur. , CAS No.557-04-0

CAS: 557-04-0 Cat. No.: M110511 Molecular Weight: 591.24 Beilstein Registry Number: 3919702 EC Number: 209-150-3

GRADE & PURITY PharmPure™, USP, Ph.Eur.

Synonyms

MAGNESIUM STEARATE [MI] | Octadecanoic acid, magnesium salt (2:1) | D02189 | DTXSID2027208 | Magnesium distearate, pure | HQKMJHAJHXVSDF-UHFFFAOYSA-L | Synpro 90 | AI3-01638 | Magnesium distearate | Magnesium stearate (JP17/NF) | Dibasic magnesium stearat

Storage

Room temperature,Desiccated

Shipped In

Normal

Overview

It has been used as a tablet and capsule lubricant, and has also been used for preparing microcapsules.

Specifications

Synonyms

MAGNESIUM STEARATE [MI] | Octadecanoic acid, magnesium salt (2:1) | D02189 | DTXSID2027208 | Magnesium distearate, pure | HQKMJHAJHXVSDF-UHFFFAOYSA-L | Synpro 90 | AI3-01638 | Magnesium distearate | Magnesium stearate (JP17/NF) | Dibasic magnesium stearat

Specifications & Purity

PharmPure™, USP, Ph.Eur.

Storage

Room temperature, Desiccated

Shipped In

Normal

Grade

Ph.Eur., PharmPure™, USP

Names and Identifiers

• Canonical Smiles: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
• IUPAC Name: magnesium;octadecanoate
• InChIKey: HQKMJHAJHXVSDF-UHFFFAOYSA-L
• INCHI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
• Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
• RTECS: WI4390000
• Molecular Weight: 591.24
• Beilstein: 3919702
• Reaxy-Rn: 3919702
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3919702&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Straight chain fatty acids Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Not available
• Substituents: Long-chain fatty acid - Straight chain fatty acid - Carboxylic acid salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: magnesium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Molecular Weight: 591.200 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 30
• Exact Mass: 590.512 Da
• Monoisotopic Mass: 590.512 Da
• Topological Polar Surface Area: 80.300 Ų
• Heavy Atom Count: 41
• Formal Charge: 0
• Complexity: 196.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Kunming Sun, Tinghui Deng, Jing Sun, Shuo Gao, Huwei Liu, Shuyun Zhu, Xian-En Zhao.  (2022)  Ratiometric fluorescence detection of artemisinin based on photoluminescent Zn-MOF combined with hemin as catalyst.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36542922] [10.1016/j.saa.2022.122253]

2. Ye Qianyu, Ding Meilai, Zhang Ping, Wu Peng, Wang Yong, Selomulya Cordelia, Chen Xiao Dong.  (2022)  Visual Monitoring of Disintegration of Solid Oral Dosage Forms in Simulated Gastric Fluids Using Low-Field NMR Imaging.  AAPS PHARMSCITECH,  23  (7): (1-12).  [PMID:36050431] [10.1208/s12249-022-02401-x]

3. Meng Xia, Fengjin Shi, Yinghui Xia, Jing Sun, Xian-En Zhao, Shuyun Zhu.  (2021)  Ce4+-triggered cascade reaction for ratiometric fluorescence detection of alendronate.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:33461138] [10.1016/j.saa.2021.119437]

4. Shao-Bin He, Liu Yang, Xiu-Ling Lin, Li-Ming Chen, Hua-Ping Peng, Hao-Hua Deng, Xing-Hua Xia, Wei Chen.  (2019)  Heparin-platinum nanozymes with enhanced oxidase-like activity for the colorimetric sensing of isoniazid.  TALANTA,      [PMID:32070586] [10.1016/j.talanta.2019.120707]

5. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi.  (2019)  Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study.  SAUDI PHARMACEUTICAL JOURNAL,      [PMID:31997907] [10.1016/j.jsps.2019.08.002]

6. Shuyun Zhu, Xiaolu Yan, Jing Sun, Xian-En Zhao, Xiao Wang.  (2019)  A novel and sensitive fluorescent assay for artemisinin with graphene quantum dots based on inner filter effect.  TALANTA,      [PMID:31036169] [10.1016/j.talanta.2019.03.058]

7. Siyuan Chen, Jiabao Lu, Jiachun Feng.  (2018)  3D-Printable ABS Blends with Improved Scratch Resistance and Balanced Mechanical Performance.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.7b05074]

8. Ningzi Guo, Sijing Niu, Ying Geng, Guangzhi Shan, Ningyi Wei, Hua Chen.  (2025)  Non-destructive quantification of low colchicine concentrations in commercially available tablets using transmission raman spectroscopy with partial least squares.  International Journal of Pharmaceutics-X,      [PMID:40094145] [10.1016/j.ijpx.2025.100321]

9. Wenchen Pu, Xianyan Shen, Xin Fan, Yuanyuan Zheng, Xuesha Liu, Jiao Li, Jian-Kang Zhou, Juan He, Rong Wei, Yanqiu Gong, Qingquan Zheng, Yao Luo, Yingli Guo, Min Ai, Yue Ming, Zixia Ye, Yun Zhao, Chun Wang, Yong Peng.  (2025)  Structure-Guided Optimization and Preclinical Evaluation of 6-O-Benzylguanine-Based Pin1 Inhibitor for Hepatocellular Carcinoma Treatment.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39868498] [10.1021/acs.jmedchem.4c02144]

10. Chenyang Zhao, Xiaolei Wang, Yanbo Liu, Xueyou Qin, Weiqi Chen, Jin Zhang, Songgu Wu, Junbo Gong.  (2024)  Uncovering the mechanism of Tenofovir amibufenamide fumarate punch sticking by combining direct compression experiment and computational simulation.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:38272192] [10.1016/j.ijpharm.2024.123813]

11. Zhang Jin, Su Ning, Liu Wei, Li Mengran, Zheng Haoyang, Li Bing, Jin Xue, Gao Mingxia, Zhang Xiangmin.  (2025)  An effective cell-penetrating peptide-based loading method to extracellular vesicles and enhancement in cellular delivery of drugs.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:39836222] [10.1007/s00216-025-05742-1]

12. Chenguang Lu, Wenzong Li, Xu Wang, Lemin Zhang, Jiahui Chu, Ningning Sun, Zetian Xing, Zhongyi Wang, Shile Feng, Yu Sun, Yahua Liu.  (2025)  A Yeast-Fermented Porous Coating for Anti-Icing Enabled by Photothermal Trapping and Crack Promotion.  ACS Applied Materials & Interfaces,      [PMID:41406489] [10.1021/acsami.5c21683]

13. Liu Yang, Shi Qiong-zhi, Wang Yanchen, Long Ze-chun, Han Man, Zeng Yuan, Xie Xiang-yang, Liu Hui.  (2026)  Development and Evaluation of Multiple-Unit Tablets for the Controlled Release of Lornoxicam.  DRUGS IN R&D,      [PMID:] [10.1007/s40268-026-00540-1]