Maprotiline - Moligand™, ≥98% , Channel blocker of K ir3.2;Channel blocker of K ir3.4;Inhibitor of NET;Channel blocker of TRPM3, CAS No.10262-69-8, Channel blocker of K ir3.2;Channel blocker of K ir3.4;Inhibitor of NET;Channel blocker of TRPM3

CAS: 10262-69-8 Cat. No.: M338146 Summenformel: C₂₀H₂₃N Molekulargewicht: 277.40 Beilstein Registry Number: 2385493 EG-Nummer: 233-599-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

Maprotylina | DB00934 | 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine | NCGC00015708-05 | NCGC00015708-11 | BDBM50378025 | HMS2089K11 | NCGC00015708-13 | NCGC00015708-02 | NCGC00016691-01 | SPBio_002332 | KBio2_001367 | Maprotilina [INN-Spanis

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1

Specifications

Synonyme

Maprotylina | DB00934 | 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine | NCGC00015708-05 | NCGC00015708-11 | BDBM50378025 | HMS2089K11 | NCGC00015708-13 | NCGC00015708-02 | NCGC00016691-01 | SPBio_002332 | KBio2_001367 | Maprotilina [INN-Spanis

Spezifikationen & Reinheit

Moligand™, ≥98%

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

CHANNEL BLOCKER, INHIBITOR

Mechanismus der Wirkung

Channel blocker of K ir3.2;Channel blocker of K ir3.4;Inhibitor of NET;Channel blocker of TRPM3

Reinheit

≥98%

Namen und Kennungen

Pubchem Sid

528776563

Kanonisches Lächeln

CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24

IUPAC Name

N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine

InChIKey

QSLMDECMDJKHMQ-UHFFFAOYSA-N

INCHI

1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3

Isomere SMILES

CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24

Alternative CAS-Nummer

10347-81-6

Molekulargewicht

277.40

Beilstein

2385493

Reaxy-Rn

2385493

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2385493&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Anthracenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Anthracenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Anthracenes
• Alternative Parents: Tetralins Aralkylamines Dialkylamines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Anthracene - Tetralin - Aralkylamine - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as anthracenes. These are organic compounds containing a system of three linearly fused benzene rings.
• External Descriptors: anthracenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (1 Activities)

Discover Target: TRPM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ6 Tchem G protein-activated inward rectifier potassium channel 2 (1 Activities)

Discover Target: KCNJ6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor (3 Activities)

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter (4 Activities)

Discover Target: SLC6A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (1 Activities)

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 (1 Activities)

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A (2 Activities)

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C (2 Activities)

Discover Target: HTR2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ5 Tchem G protein-activated inward rectifier potassium channel 4 (1 Activities)

Discover Target: KCNJ5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water (slightly).
• Brechungsindex: n20D1.60 (Predicted)
• Siedepunkt (°C): ~399.6° C at 760 mmHg (Predicted)
• Schmelzpunkt (°C): 93° C
• Molekulargewicht: 277.400 g/mol
• XLogP3: 4.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 277.183 Da
• Monoisotopic Mass: 277.183 Da
• Topological Polar Surface Area: 12.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 339.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1