Margatoxin, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7, CAS No.145808-47-5, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7

CAS: 145808-47-5 Cat. No.: M287709 Summenformel: C₁₇₈H₂₈₆N₅₂O₅₀S₇ Molekulargewicht: 4178.96 EG-Nummer: 686-414-8 PubChem CID: 121596045
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QUALITÄT & REINHEIT Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Preis
Menge
100μg
M287709-100μg
Auf Bestellung · 8–12 Wochen
260,23€
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Warum diese Qualität

Moligand™ Moligand™ für empfindliche chromatographische und analytische Workflows, die minimale Basislinieninterferenzen erfordern.

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Lagerung & Versand

Store at -20°C Versand Ice chest + Ice pads. Genaue Spezifikationen finden Sie im chargenspezifischen COA.

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Qualitätsdokumente

SDS, COA, Datenblatt und Spezifikationsblatt stehen zum Download bereit. Chargenspezifische COA über Chargennummernsuche abrufbar.

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Literaturbeleg

In 0 peer-reviewten Publikationen zu Chromatographie, organischer Synthese und Kreuzkupplungsreaktionen zitiert.

Spezifikationen

Product Name
Margatoxin, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7, CAS No.145808-47-5
Synonyme
UNII-6197NL836C | 6197NL836C | HB1083 | Margatoxin | C178H286N52O50S7
Note
Moligand™
Spezifikationen & Reinheit
Moligand™
Biochemische und physiologische Mechanismen
Potent KV1.3 channel blocker (IC50= 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.
Sequenz
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Modifications: Disulfide bridge between 7 - 29, 13 - 34, 17 - 36)
Aktionsart
CHANNEL BLOCKER
Mechanismus der Wirkung
Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7
CAS
145808-47-5
Molekültyp
Kleines Molekül
Lagerung und Versand
Storage
Store at -20°C
Verschickt in
Ice chest + Ice pads

Dokumentation

📋 Sicherheitsdatenblatt (SDS)

Umfassendes Dokument zu Gefahren, Handhabung, Lagerung und Einhaltung regulatorischer Vorschriften.

<<<<<<< HEAD SDS herunterladen → ======= SDS herunterladen → >>>>>>> release248-p3

✅ Analysezertifikat (COA)

Chargenspezifische Qualitätsdaten. Geben Sie Ihre Chargennummer ein, um das genaue COA abzurufen.

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📊 Datenblatt

Kurzübersicht über Produktspezifikationen und Anwendungen.

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🔬 Spezifikationsblatt

Vollständige Qualitätsmerkmale und Akzeptanzkriterien für diese Qualität.

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Erweiterte Daten

3D-Struktur
Interaktives chemisches Strukturmodell





Zugehörige Ziele (menschlich)
KCNA7 Tclin Potassium voltage-gated channel subfamily A member 7 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNA3 Tclin Potassium voltage-gated channel subfamily A member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNA2 Tclin Potassium voltage-gated channel subfamily A member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNA1 Tclin Potassium voltage-gated channel subfamily A member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Genetische Informationen
Alternate NamesUNII-6197NL836C | 6197NL836C | HB1083 | Margatoxin | C178H286N52O50S7
Referenz
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
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What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 145808-47-5. InChIKey OVJBOPBBHWOWJI-FYNXUGHNSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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