Mibampator - 10mM in DMSO , Glutamate receptor ionotropic AMPA positive allosteric modulator, CAS No.375345-95-2, Glutamate receptor ionotropic AMPA positive allosteric modulator

CAS: 375345-95-2 Cat. No.: M655739 Molecular Weight: 438.60 PubChem CID: 9889366

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

In Vivo

Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species . LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:AMPA receptor

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

POSITIVE ALLOSTERIC MODULATOR

Mechanism of action

Glutamate receptor ionotropic AMPA positive allosteric modulator

Product Properties

• ALogP: 3.4

Names and Identifiers

• Isomeric SMILES: C[C@@H](CNS(=O)(=O)C(C)C)C1=CC=C(C=C1)C2=CC=C(C=C2)CCNS(=O)(=O)C
• Alternate CAS: 375345-95-2
• PubChem CID: 9889366
• MeSH Entry Terms: LY 451395;LY-451395;LY451395;N-((2-(4'-(2-(methylsulfonyl)amino)ethyl)(1,1'-biphenyl)-4-yl)propyl)-2-propanesulfonamide
• Molecular Weight: 438.60

Associated Targets(Human)

GRIA4 Tclin Glutamate receptor 4 (1 Activities)

Discover Target: GRIA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)