MM 419447 - ≥99% , CAS No.1092457-78-7

CAS: 1092457-78-7 Cat. No.: M648536 Summenformel: C₅₀H₇₀N₁₄O₁₉S₆ Molekulargewicht: 1363.56

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).

In Vitro

MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MM 419447 (10 mg/kg; p.o.) treatment shows the C max , AUC 0-6 and t 1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague-Dawley rats Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The C max , AUC 0-6 and T max were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.

Form:Solid

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).

Storage

Desiccated,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 1363.56

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 100 mg/mL (73.34 mM; Need ultrasonic)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1092457-78-7, the molecular formula is C50H70N14O19S6, and the molecular weight is 1363.56 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.