MS8815 - ≥99% , CAS No.2855085-25-3

CAS: 2855085-25-3 Cat. No.: M647567 Summenformel: C₆₅H₈₇N₉O₈S Molekulargewicht: 1154.51

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Application

PROTAC

Übersicht

MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC 50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC)

In Vitro

MS8815 shows potency in inhibiting the EZH2 and EZH1 methyltransferase activity with IC 50 values of 8.6 nM and 62 nM, respectively. MS8815 (0.1-1 μM) degrades EZH2 with a DC 50 value of 140 nM in MDA-MB-453 cells. MS8815 (1 μM; 48 h) induces robust EZH2 degradation in a concentration-, time-, and proteasome-dependent manner in TNBC cells. MS8815 (0.1-10 μM; 5 days) effectively suppresses the cell growth in multiple TNBC cell lines and primary patient TNBC cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-453 cells and BT549 cells Concentration: 0.3, 3 μM; 1μM Incubation Time: 48 h; 24 h Result: Induced nearly complete degradation of EZH2 and exhibited the most robust degradation at 0.3 μM. Induced EZH2 degradation in a time-and concentration-dependent manner. Induced EZH2 degradation through the UPS. Cell Proliferation AssayCell Line: BT549, MDA-MB-468, SUM159 and MDA-MB-453 cells Concentration: 0.1-10 μM Incubation Time: 5 days Result: Showed superior cellular growth inhibition activity in a panel of TNBC cells.

Form:Solid

IC50& Target:IC50: 8.6 nM (EZH2),62 nM (EZH1),DC50: 140 nM (EZH2 in MDA-MB-453 cells)

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC 50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC).

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 1154.51

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 120 mg/mL (103.94 mM; Need ultrasonic)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2855085-25-3, the molecular formula is C65H87N9O8S, and the molecular weight is 1154.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.