N-Hydroxyphthalimide - ≥98% , CAS No.524-38-9

CAS: 524-38-9 Cat. No.: H106354 Molecular Weight: 163.13 Beilstein Registry Number: 131208 EC Number: 208-358-1
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
CFMZSMGAMPBRBE-UHFFFAOYSA- | BXI99M81X0 | N-Hydroxyphalimide | 1H-Isoindole-1, 2-hydroxy- | N-HYDROXYPHTHALIMIDE [MI] | N-Hydroxyphthalimide, Vetec(TM) reagent grade, 97% | N-hydroxypthalimide | Phthalimide, N-hydroxy- | Phthaloxime | EINECS 208-358-1 | F
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25g
H106354-25g
7

$14.90

$22.90
Save $8.00 (34.93%)
100g
H106354-100g
6

$19.90

$29.90
Save $10.00 (33.44%)
250g
H106354-250g
2

$21.90

$32.90
Save $11.00 (33.43%)
500g
H106354-500g
2

$23.90

$35.90
Save $12.00 (33.43%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 21 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
CFMZSMGAMPBRBE-UHFFFAOYSA- | BXI99M81X0 | N-Hydroxyphalimide | 1H-Isoindole-1, 2-hydroxy- | N-HYDROXYPHTHALIMIDE [MI] | N-Hydroxyphthalimide, Vetec(TM) reagent grade, 97% | N-hydroxypthalimide | Phthalimide, N-hydroxy- | Phthaloxime | EINECS 208-358-1 | F
Specifications & Purity
≥98%
Storage
Room temperature
Shipped In
Normal
Purity
≥98%
Names and Identifiers
Pubchem Sid488181155
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488181155
Canonical SmilesC1=CC=C2C(=C1)C(=O)N(C2=O)O
IUPAC Name2-hydroxyisoindole-1,3-dione
InChIKeyCFMZSMGAMPBRBE-UHFFFAOYSA-N
INCHI1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)8(11)9(7)12/h1-4,12H
Isomeric SMILES C1=CC=C2C(=C1)C(=O)N(C2=O)O
WGK Germany 3
RTECS TI5200000
Molecular Weight 163.13
Beilstein 131208
Reaxy-Rn 131208
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=131208&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassIsoindoles and derivatives
SubclassIsoindolines
Intermediate Tree Nodes Isoindolones
Direct ParentPhthalimides
Alternative Parents Isoindoles  Benzenoids  Hydroxamic acids  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Phthalimide - Isoindole - Benzenoid - Hydroxamic acid - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as phthalimides. These are aromatic heterocyclic compounds containing a 1,3-dioxoisoindoline moiety. They are imide derivatives of phthalic anhydrides.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Gallus gallus (1187 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
unidentified influenza virus (265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PA Polymerase acidic protein (806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

24 results found

Lot NumberCertificate TypeDateItem
F2225321Certificate of AnalysisApr 02, 2026 H106354
F2225320Certificate of AnalysisApr 02, 2026 H106354
A2210201Certificate of AnalysisOct 13, 2025 H106354
I2504419Certificate of AnalysisJul 01, 2024 H106354
I2504418Certificate of AnalysisJul 01, 2024 H106354
H2026156Certificate of AnalysisJun 14, 2024 H106354
I2405240Certificate of AnalysisMar 26, 2024 H106354
D2613036Certificate of AnalysisAug 28, 2023 H106354
I2311766Certificate of AnalysisAug 28, 2023 H106354
I2311765Certificate of AnalysisAug 28, 2023 H106354
I2311549Certificate of AnalysisAug 28, 2023 H106354
I2311548Certificate of AnalysisAug 28, 2023 H106354
I2311541Certificate of AnalysisAug 28, 2023 H106354
D2617126Certificate of AnalysisAug 28, 2023 H106354
I2311540Certificate of AnalysisAug 28, 2023 H106354
E2324701Certificate of AnalysisApr 23, 2023 H106354
E2324652Certificate of AnalysisApr 23, 2023 H106354
E2324706Certificate of AnalysisApr 23, 2023 H106354
E2324705Certificate of AnalysisApr 23, 2023 H106354
E2324704Certificate of AnalysisApr 23, 2023 H106354
E2324665Certificate of AnalysisApr 23, 2023 H106354
F2225319Certificate of AnalysisMar 26, 2022 H106354
F2225318Certificate of AnalysisMar 26, 2022 H106354
D2314066Certificate of AnalysisMar 26, 2022 H106354

Show more ⌵

Chemical and Physical Properties
SolubilitySlightly soluble in water.
Melt Point(°C)233-235°C
Molecular Weight163.130 g/mol
XLogP30.800
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass163.027 Da
Monoisotopic Mass163.027 Da
Topological Polar Surface Area57.600 Ų
Heavy Atom Count12
Formal Charge0
Complexity214.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Zhu Guozhi, Shi Song, Feng Xiao, Zhao Li, Cao Jieqi, Wang Yinwei, Sun Zhiqiang, Gao Jin, Xu Jie.  (2022)  Aerobic Selective Oxidation of Cyclohexylbenzene Over Organocatalysis with Pairs of Nitrogenous Hydroxyl Precursors and Anthraquinones.  CATALYSIS LETTERS,  153  (5): (1300-1307).  [PMID:] [10.1007/s10562-022-04076-2]
2. Jilan Qi, Xiaolei Zhang, Qiangyan Zhang, Ying Xue, Fei Meng, Yuanhua Liu, Gongjun Yang.  (2022)  Ultrasensitive “signal-on” sandwich electrochemiluminescence immunosensor based on Pd@Au-L-cysteine enabled multiple-amplification strategy for Apolipoprotein-A1 detection.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107409]
3. Wang Huimin, Wang Xiaoying, Sun Tingting, Li Peixin, Chu Xiaomeng, Xing Xuteng, Liu Shaojie, Tang Erjun.  (2021)  Recoverable, water-soluble polyethylene glycol-immobilized N-hydroxyphthalimide, as mediator for cellulose oxidation in the presence of NaBr and NaClO.  CELLULOSE,  28  (18): (11315-11328).  [PMID:] [10.1007/s10570-021-04263-1]
4. Bilal Ul Amin, Haojie Yu, Li Wang, Ahsan Nazir, Shah Fahad, Fazal Haq, Sahid Mahmood, Md Alim Uddin, Tarig Elshaarani, Di Shen.  (2020)  Synthesis of Ferrocene-based Esters as Burning Rate Catalysts and their Anti-migration Study.  ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE,  646  (20): (1671-1678).  [PMID:] [10.1002/zaac.202000253]
5. Wenjun Li, Chaoyun Ma, Yiju Song, Chenglin Hong, Xiuwen Qiao, Bincheng Yin.  (2020)  Sensitive detection of carcinoembryonic antigen (CEA) by a sandwich-type electrochemical immunosensor using MOF-Ce@HA/Ag-HRP-Ab2 as a nanoprobe.  NANOTECHNOLOGY,  31  (18): (185605).  [PMID:31995543] [10.1088/1361-6528/ab70d3]
6. Huifang Liu, Hongji Li, Nengchao Luo, Feng Wang.  (2019)  Visible-Light-Induced Oxidative Lignin C–C Bond Cleavage to Aldehydes Using Vanadium Catalysts.  ACS Catalysis,      [PMID:] [10.1021/acscatal.9b03768]
7. Fei Xia, Jiping Ma, Xiuquan Jia, Meiling Guo, Xuebin Liu, Hong Ma, Jin Gao, Jie Xu.  (2019)  Catalytic Synthesis of 2,5-Furandicarboxylic Acid from Concentrated 2,5-Diformylfuran Mediated by N-hydroxyimides under Mild Conditions.  Chemistry-An Asian Journal,  14  (19): (3329-3334).  [PMID:31411005] [10.1002/asia.201901001]
8. Yuewen Yu, JingJing Yang, Xiaohui Xu, Yuliang Jiang, Bingxiang Wang.  (2017)  A novel fluorescent probe for highly sensitive and selective detection of cysteine and its application in cell imaging.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.05.150]
9. Wang Youpeng, Li Guo, Cheng Ruidong, Zhang Xuan, Jiang Jinqiang.  (2017)  NIR- and UV-dual responsive amphiphilic copolymer micelles with light-dissociable PAG-side groups.  COLLOID AND POLYMER SCIENCE,  295  (2): (371-378).  [PMID:] [10.1007/s00396-017-4013-0]
10. Meng Yu, Yi Di, Ying Zhang, Yuting Zhang, Jia Guo, Haojie Lu, Changchun Wang.  (2016)  Fabrication of Alkoxyamine-Functionalized Magnetic Core-Shell Microspheres via Reflux Precipitation Polymerization for Glycopeptide Enrichment.  Polymers,  (3): (74).  [PMID:30979171] [10.3390/polym8030074]
11. Chaoran Xu, Wei He, Yaqi Lv, Chao Qin, Lingjia Shen, Lifang Yin.  (2015)  Self-assembled nanoparticles from hyaluronic acid–paclitaxel prodrugs for direct cytosolic delivery and enhanced antitumor activity.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:26232702] [10.1016/j.ijpharm.2015.07.069]
12. Ruidong Cheng, Min Tian, Sujuan Sun, Chenghui Liu, Youpeng Wang, Zhaotie Liu, Zhongwen Liu, Jinqiang Jiang.  (2015)  Light-Triggered Disruption of PAG-Based Amphiphilic Random Copolymer Micelles.  LANGMUIR,      [PMID:26101111] [10.1021/acs.langmuir.5b01535]
13. Haoran Yuan, Zejie Zhu, Lingyao Wang, Jia Yao, Haoran Li.  (2024)  A cooperation of ceric ammonium nitrate and N-hydroxyphthalimide in the aerobic oxidation from ketones to lactones/esters: Catalytic characterization and mechanistic investigation.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2024.139973]
14. Lihong Ding, Xiuliang Sun, Chongpin Huang, Jianwei Li, Biaohua Chen.  (2024)  Cooperative effect of NHPI and BmimBr for promoting cumene catalytic oxidation.  APPLIED CATALYSIS A-GENERAL,      [PMID:] [10.1016/j.apcata.2024.119731]
15. Runzi Ding, Xueying Liu, Haijiao Yu, Sheldon Q. Shi, Guangping Han, Wanli Cheng.  (2024)  Effects of different oxidation systems on the interfacial properties of bamboo fiber/epoxy resin composites.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2024.103843]
16. Kefan Yu, Dezhong Xie, Fengkuan Ma, Qiaohong Zhang, Hongying Lü, Chen Chen.  (2024)  Efficient selective oxidation of hydrocarbon at ambient temperature under photoirradiation being promoted with the in-situ catalytic decomposition of peroxide.  FUEL,      [PMID:] [10.1016/j.fuel.2024.134163]
17. Tianqi Hu, Yi Luo, Yunsheng Zhu, Yaming Chu, Guoxiang Hu, Xiong Xu.  (2024)  Mechanochemical preparation and performance evaluations of bitumen-used waste polypropylene modifiers.  Case Studies in Construction Materials,      [PMID:] [10.1016/j.cscm.2024.e03471]
18. Honglong Zhang, Qiaoqiao Zhao, Kangbao Zhong, Ruopeng Bai, Jiaojiao Dong, Jun Ma, Jing Zhang, Timothy J. Strathmann.  (2024)  Overlooked interaction between redox-mediator and bisphenol-A in permanganate oxidation.  Environmental Science and Ecotechnology,      [PMID:38774192] [10.1016/j.ese.2024.100421]
19. Kui Jin, Meiyun Zhang, Penghua Che, Dongru Sun, Yong Wang, Hong Ma, Qiaohong Zhang, Chen Chen, Jie Xu.  (2024)  Solvent-scissors overcoming inert hydrogen bonding enable efficient oxidation of aromatic hydrocarbons under atmospheric oxygen.  CHINESE JOURNAL OF CATALYSIS,      [PMID:] [10.1016/S1872-2067(24)60042-2]
20. Yuxi Li, Zhuwei Zhu, Ximai Zhang, Fengkuan Ma, Qiaohong Zhang, Chen Chen, Hongying Lü.  (2025)  Selective Oxidation of Hydrocarbon with NHPI/Facet-Mediated α-Fe2O3 under the Visible-light at Ambient Temperature.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.118760]
21. Yanhao Liu, Shubin Li, Jiang Zhu, Lili Fan, Lu Wang.  (2025)  Mechanically enhanced chitosan hydrogels based on micellar cross-linking for wound hemostasis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40373922] [10.1016/j.ijbiomac.2025.144231]
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.