Serotonin hydrochloride - 10mM in DMSO , CAS No.153-98-0

CAS: 153-98-0 Cat. No.: S421830 Summenformel: C₁₀H₁₂N₂O·HCl Molekulargewicht: 212.68 Beilstein Registry Number: 3570963 EG-Nummer: 628-480-2 PubChem CID: 160436

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

5-HT | 5-HT hydrochloride | CHEBI:181195 | SR-01000075577-1 | 5-HT HCl | 5-hydroxy tryptamine hydrochloride | A809482 | MFCD00020019 | Serotonin hydrochloride(5-HT) | CCG-214216 | EINECS 244-464-4 | Q27279146 | (+/-)-7,8-DIMETHYLTOCOL | 5-Hydroxytryptamin

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Serotonin hydrochloride is the salt form of Serotonin, a monoamine neurotransmitter biochemically derived from tryptophan. This neurotransmitter is located in the central nervous system and functions as an endogenous SR (serotonin receptor) agonist in a variety of biochemical processes. In the majority of the human bodies, serotonin is located in enterochromaffin (”Kulchitsky cells”). Serotonin is found in the gastrointestinal tract and platelets. Furthermore, Serotonin functions as a growth factor in some cells and facilitates wound healing in conjunction with platelets. Serotonin is thought to be a key component in the regulation of moods, cognition, and personality traits. As a result, this compound is essential in studying the variations in these traits.
A tryptophan based amino acid neurotransmitter.

Spezifikationen

Synonyme

5-HT | 5-HT hydrochloride | CHEBI:181195 | SR-01000075577-1 | 5-HT HCl | 5-hydroxy tryptamine hydrochloride | A809482 | MFCD00020019 | Serotonin hydrochloride(5-HT) | CCG-214216 | EINECS 244-464-4 | Q27279146 | (+/-)-7,8-DIMETHYLTOCOL | 5-Hydroxytryptamin

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Endogenous 5-HT receptor agonist. Neurotransmitter involved in diverse physiological functions such as mood, appetite, sleep, sex and temperature in addition to modulating cardiovascular function and the gastrointestinal system.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Kanonisches Lächeln

C1=CC2=C(C=C1O)C(=CN2)CCN.Cl

IUPAC Name

3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride

InChIKey

MDIGAZPGKJFIAH-UHFFFAOYSA-N

INCHI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

Isomere SMILES

C1=CC2=C(C=C1O)C(=CN2)CCN.Cl

WGK Deutschland

3

RTECS

NM2571000

PubChem CID

160436

UN-Nummer

2811

Molekulargewicht

212.68

Beilstein

3570963

Reaxy-Rn

3570963

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Indoles and derivatives
      • Subclass Tryptamines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Indoles and derivatives
• Subclass: Tryptamines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Serotonins
• Alternative Parents: Hydroxyindoles 3-alkylindoles 2-arylethylamines Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Monoalkylamines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Serotonin - Hydroxyindole - 3-alkylindole - Indole - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Azacycle - Amine - Hydrochloride - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as serotonins. These are compounds containing a serotonin moiety, which consists of an indole that bears an aminoethyl a position 2 and a hydroxyl group at position 5.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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HTR1B Tclin 5-hydroxytryptamine receptor 1B (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR5A Tchem 5-hydroxytryptamine receptor 5A (0 Activities)

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HTR4 Tclin 5-hydroxytryptamine receptor 4 (0 Activities)

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HTR2A Tclin 5-hydroxytryptamine receptor 2A (0 Activities)

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HTR1E Tchem 5-hydroxytryptamine receptor 1E (0 Activities)

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HTR7 Tclin 5-hydroxytryptamine receptor 7 (0 Activities)

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HTR1D Tclin 5-hydroxytryptamine receptor 1D (0 Activities)

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HTR1F Tclin 5-hydroxytryptamine receptor 1F (0 Activities)

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HTR2C Tclin 5-hydroxytryptamine receptor 2C (0 Activities)

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HTR1A Tclin 5-hydroxytryptamine receptor 1A (1 Activities)

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HTR3A Tclin 5-hydroxytryptamine receptor 3A (0 Activities)

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HTR6 Tchem 5-hydroxytryptamine receptor 6 (0 Activities)

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HTR2B Tclin 5-hydroxytryptamine receptor 2B (0 Activities)

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ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

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AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)

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GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

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CSNK1D Tchem Casein kinase I delta (4546 Activities)

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KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

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CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)

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FLT4 Tclin Vascular endothelial growth factor receptor 3 (3216 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)

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AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

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U2OS (164939 Activities)

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CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)

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FPR2 Tchem Lipoxin A4 receptor (3472 Activities)

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FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

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GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)

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GMNN Tbio Geminin (128009 Activities)

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

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TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)

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BRPF1 Tchem Peregrin (2217 Activities)

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HEK-293T (167025 Activities)

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ampC Beta-lactamase AmpC (62480 Activities)

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Aplnr Apelin receptor (201 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Large T antigen (1457 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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nfo Endonuclease 4 (425 Activities)

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TyR1 (19 Activities)

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SARS-CoV-2 (38078 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Moisture & Light sensitive
• Schmelzpunkt (°C): 168-172°C
• Molekulargewicht: 212.670 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.072 Da
• Monoisotopic Mass: 212.072 Da
• Topological Polar Surface Area: 62.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 174.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3