Single Chain High MW Kininogen

Cat. No.: S1526727

GRADE & PURITY BioReagent, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Overview

High Molecular Weight Kininogen (HK) is a nonenzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor α-Xlla. HK also forms a complex with Factor XI and accelerates its activation to XIa by α-Xlla. Also HK serves as a source of Bradykinin, a potent Vasoactive peptide important in hypotension studies. The Single Chain High MW Kininogen is greater than 95% single chain. Extinction Coefficient (1%) = 7.01 Molecular Weight = 120,000 daltons The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.

Specifications

Product Name

Single Chain High MW Kininogen

Grade

BioReagent

Specifications & Purity

BioReagent, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Molecule Type

Protein

Storage and Shipping

Concentration

from Human plasma; Protein concentration: See COA

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs