Tacedinaline (CI994) - Moligand™, 10mM in DMSO , Histone deacetylase inhibitor, CAS No.112522-64-2, Histone deacetylase inhibitor

CAS: 112522-64-2 Cat. No.: T407867 Summenformel: C₁₅H₁₅N₃O₂ Molekulargewicht: 269.3 EG-Nummer: 631-226-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PD-123654, GOE-5549, Acetyldinaline | Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class IHDACinhibitor withIC50of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.
In vitro

CI-994 (< 160 mM) shows cytostatic effect with concomitant increase at G0/G1 phase, a reduction at S phase level and increased apoptosis in A-549 and LX-1 cells. CI-994 inhibits growth of LNCaP cell with IC50 of 7.4 μM. CI-994 exerts activity against several tumor cell lines with greater cytotoxicity against the solid tumors relative to both the leukemia and normal fibroblast cell lines. CI-994 inhibits growth of rat leukemia BCLO cells with IC50 of 2.5 μM.

In vivo

CI-994 exerts demonstrated antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.
Cell Data

cell lines：

Concentrations：2.5 μM

Incubation Time：2-4 days

Powder Purity:≥99%

Specifications

Synonyme

PD-123654, GOE-5549, Acetyldinaline | Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Histone deacetylase inhibitor

Produkteigenschaften

• ALogP: 1.3

Namen und Kennungen

• Isomere SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N
• WGK Deutschland: 3
• RTECS: CU8702023
• Molekulargewicht: 269.3
• Reaxy-Rn: 8422586
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8422586&ln=

Zugehörige Ziele (menschlich)

HDAC1 Tclin Histone deacetylase 1 (8 Activities)

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 (5 Activities)

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 (3 Activities)

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 42.6 mg/mL (124.41 mM)
• Schmelzpunkt (°C): 242 °C(dec.)