Thiazol Orange - Dye content,~90% , CAS No.107091-89-4

CAS: 107091-89-4 Cat. No.: T131378 Molecular Weight: 476.61 EC Number: 628-432-0 PubChem CID: 6438345

GRADE & PURITY Dye content,~90%

Synonyms

PD063601 | CBFbeta-Runx1 inhibitor II | Arctigenen | 1-Methyl-4-[(3-methyl-2(3H)-benzothiazolylidene)methyl]quinolinium p-tosylate | 3-Methyl-2-[(1-methylquinolin-4(1H)-ylidene)methyl]-1,3-benzothiazol-3-ium 4-methylbenzene-1-sulfonate | 1-methyl-4-((3-me

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

Thiazol Orange is a nucleic acid stain that has found applications in many different areas. Among others it is used for reticulocyte analysis and Plasmodium species analysis as well as labeling cancer cells. absorption λmax 512 nm
A fluorescent dye for reticulocyte analysis and DNA staining

Specifications

Synonyms

PD063601 | CBFbeta-Runx1 inhibitor II | Arctigenen | 1-Methyl-4-[(3-methyl-2(3H)-benzothiazolylidene)methyl]quinolinium p-tosylate | 3-Methyl-2-[(1-methylquinolin-4(1H)-ylidene)methyl]-1, 3-benzothiazol-3-ium 4-methylbenzene-1-sulfonate | 1-methyl-4-((3-me

Specifications & Purity

Dye content, ~90%

Biochemical and Physiological Mechanisms

Thiazole Orange is a fluorescent dye DNA stain used for reticulocyte analysis. Also potentially useful for Plasmodium species analysis.Fluorescent dye for reticulocyte analysis. Nucleic acid stain with high affinity for dsDNA (log K = 5.5 at 100 mM salt).

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

• Pubchem Sid: 504764177
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764177
• Canonical Smiles: CC1=CC=C(C=C1)S(=O)(=O)[O-].CN1C2=CC=CC=C2SC1=CC3=CC=[N+](C4=CC=CC=C34)C
• IUPAC Name: 4-methylbenzenesulfonate;(2Z)-3-methyl-2-[(1-methylquinolin-1-ium-4-yl)methylidene]-1,3-benzothiazole
• InChIKey: ACOJCCLIDPZYJC-UHFFFAOYSA-M
• INCHI: 1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)[O-].CN\1C2=CC=CC=C2S/C1=C\C3=CC=[N+](C4=CC=CC=C34)C
• PubChem CID: 6438345
• Molecular Weight: 476.61

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Quinolones and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Quinolones and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydroquinolones
• Alternative Parents: p-Methylbenzenesulfonates Tosyl compounds Hydroquinolines 1-sulfo,2-unsubstituted aromatic compounds Benzenesulfonyl compounds Benzothiazoles Tertiary alkylarylamines Thiazoles Sulfonyls Organosulfonic acids Heteroaromatic compounds Allylamines Enamines Azacyclic compounds Hydrocarbon derivatives Organopnictogen compounds Organic oxides Organic salts
• Molecular Framework: Not available
• Substituents: Dihydroquinolone - P-methylbenzenesulfonate - Dihydroquinoline - Benzenesulfonate - Tosyl compound - Arylsulfonic acid or derivatives - 1,3-benzothiazole - Benzenesulfonyl group - 1-sulfo,2-unsubstituted aromatic compound - Tertiary aliphatic/aromatic amine - Toluene - Monocyclic benzene moiety - Benzenoid - Azole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Thiazole - Heteroaromatic compound - Tertiary amine - Allylamine - Enamine - Azacycle - Amine - Organic nitrogen compound - Organosulfur compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Organic salt - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as hydroquinolones. These are compounds containing a hydrogenated quinoline bearing a ketone group.
• External Descriptors: cyanine dye

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in DMSO.
• Sensitivity: Moisture sensitive；Light sensitive；Heat sensitive
• Melt Point(°C): 270 °C
• Molecular Weight: 476.600 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 476.123 Da
• Monoisotopic Mass: 476.123 Da
• Topological Polar Surface Area: 98.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 628.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao.  (2015)  Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification.  BIOSENSORS & BIOELECTRONICS,      [PMID:25950941] [10.1016/j.bios.2015.04.076]

2. Jidong Tang, Ling Wang, Wenjin Ma, Ping Fu, Yanlin Zhang, Xiaoqiong Li, Xiaoqi Tao.  (2024)  An amplified AuNP-mediated chemiluminescence resonance energy transfer aptasensor based on Nb.BbvCI-powered DNA walker for detecting ochratoxin A in foods.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.112503]

3. Ze Chen, Zuyao Fu, Xiaoyu Du, Jing Xie, Zhaoyang Ding.  (2024)  Novel aptamer fluorescence assays for malachite green and leucomalachite green detection.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111391]