TK05 - 10mM in DMSO , CAS No.1245734-61-5

CAS: 1245734-61-5 Cat. No.: T654963 Molecular Weight: 540.99 PubChem CID: 53385780

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM

In Vitro

TK05 reduces LTC 4 production in a dose-dependent manner with an IC 50 value of 318 ± 60 nM in MM6 Cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE 4 levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Zymosan A induced peritonitis mouse model Dosage: 0.12 mg/kg; 6 mg/kg Administration: Given i.p.; only once Result: 0.12 mg/kg of TK05 significantly reduced LTE 4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.

IC50& Target:IC50: 95 nM (Leukotriene C 4 synthase)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: COC1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)C(=O)C3=NC=C(C=C3)N(CC4CC4)C5=CC=C(C=C5)Cl)C(=O)O
• PubChem CID: 53385780
• Molecular Weight: 540.99

Associated Targets(Human)

LTC4S Tchem Leukotriene C4 synthase (0 Activities)

Discover Target: LTC4S

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)