Toremifene Citrate (NK 622) - 10mM in DMSO , Estrogen receptor modulator, CAS No.89778-27-8, Estrogen receptor modulator

CAS: 89778-27-8 Cat. No.: T409054 Molecular Weight: 598.08 EC Number: 663-344-6 PubChem CID: 3005572

GRADE & PURITY 10mM in DMSO

Synonyms

NSC 613680 | 2-​[4-​[(1Z)​-​4-​chloro-​1,​2-​diphenyl-​1-​buten-​1-​yl]​phenoxy]​-​N,​N-​dimethyl-ethanamine, 2-​hydroxy-​1,​2,​3-​propanetricarboxylat​e (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Toremifene Citrate (NK 622, NSC 613680) is an oral selectiveestrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.
In vitro

Toremifene (7.5 mM) causes approximately 60% of the cells to exhibit morphologic characteristics typical of cells undergoing programmed death, or apoptosis in human breast cancer cells. Toremifene (5-10 mM) results in elevated levels of TRPM-2 and TGF beta 1 mRNAs in in vitro or in vivo grown tumor cells. Toremifene causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis. ^[1] Toremifene induces a dose-dependent level of adducts that is lower than that observed for TAM. Toremifene significantly enhances endogenous DNA adduct formation. ^[2] Toremifene affects the cell turnover by inhibiting mitotic activity and modifying abundant spontaneous apoptosis in DMBA-induced rat mammary carcinoma. ^[3]

In vivo

Toremifene, at the highest tested dose, increases the incidence of hepatocellular carcinomas in the DEN-initiated groups to a level one-third that observed with Tamoxifen administration to DEN-initiated rats. Toremifene increases the incidence of hypernephromas in previously DEN-initiated rats. ^[4] Toremifene results in aneuploidy in 50% of the cells examined and compared with the 85% level induced by Tamoxifen in female Sprague-Dawley rats. ^[5]
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 613680 | 2-​[4-​[(1Z)​-​4-​chloro-​1, ​2-​diphenyl-​1-​buten-​1-​yl]​phenoxy]​-​N, ​N-​dimethyl-ethanamine, 2-​hydroxy-​1, ​2, ​3-​propanetricarboxylat​e (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Toremifene Citrate (NK 622, NSC 613680) is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

MODULATOR

Mechanism of action

Estrogen receptor modulator

Names and Identifiers

• Isomeric SMILES: CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• WGK Germany: 3
• RTECS: KH2156700
• PubChem CID: 3005572
• Molecular Weight: 598.08

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Water: 31 mg/mL (197.18 mM); DMSO: Insoluble; Ethanol: Insoluble