UK-371804 HCl - 10mM in DMSO , CAS No.256476-36-5

CAS: 256476-36-5 Cat. No.: U422895 Summenformel: C₁₄H₁₇Cl₂N₅O₄S Molekulargewicht: 422.29 PubChem CID: 16657953

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

Alanine,N-​[[1-​[(aminoiminomethyl)​amino]​-​4-​chloro-​7-​isoquinolinyl]​sulfonyl]​-​2-​methyl-​,hydrochloride (1:1)

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

Targets

uPA (Cell-free assay) 10 nM(Ki)

In vitro

UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM).

In vivo

in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters.

Spezifikationen

Synonyme

Alanine,N-​[[1-​[(aminoiminomethyl)​amino]​-​4-​chloro-​7-​isoquinolinyl]​sulfonyl]​-​2-​methyl-​,hydrochloride (1:1)

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

Storage

Protected from light,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Pubchem Sid

528767576

Kanonisches Lächeln

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl

IUPAC Name

2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid;hydrochloride

InChIKey

IUBFETAFRGVODB-UHFFFAOYSA-N

INCHI

1S/C14H16ClN5O4S.ClH/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15;/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19);1H

Isomere SMILES

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl

PubChem CID

16657953

Molekulargewicht

422.29

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Light sensitive
• Molekulargewicht: 422.300 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 421.038 Da
• Monoisotopic Mass: 421.038 Da
• Topological Polar Surface Area: 169.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 644.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3