UK-371804 HCl - 10mM in DMSO , CAS No.256476-36-5

CAS: 256476-36-5 Cat. No.: U422895 Molecular Weight: 422.29 PubChem CID: 16657953

GRADE & PURITY 10mM in DMSO

Synonyms

Alanine,N-​[[1-​[(aminoiminomethyl)​amino]​-​4-​chloro-​7-​isoquinolinyl]​sulfonyl]​-​2-​methyl-​,hydrochloride (1:1)

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

Targets

uPA (Cell-free assay) 10 nM(Ki)

In vitro

UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM).

In vivo

in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters.

Specifications

Synonyms

Alanine, N-​[[1-​[(aminoiminomethyl)​amino]​-​4-​chloro-​7-​isoquinolinyl]​sulfonyl]​-​2-​methyl-​, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Pubchem Sid: 528767576
• Canonical Smiles: CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl
• IUPAC Name: 2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid;hydrochloride
• InChIKey: IUBFETAFRGVODB-UHFFFAOYSA-N
• INCHI: 1S/C14H16ClN5O4S.ClH/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15;/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19);1H
• Isomeric SMILES: CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl
• PubChem CID: 16657953
• Molecular Weight: 422.29

Chemical and Physical Properties

• Sensitivity: Light sensitive
• Molecular Weight: 422.300 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 421.038 Da
• Monoisotopic Mass: 421.038 Da
• Topological Polar Surface Area: 169.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 644.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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