Ulipristal Acetate (CDB 2914) - Moligand™, 10mM in DMSO , Progesterone receptor modulator, CAS No.126784-99-4, Progesterone receptor modulator

CAS: 126784-99-4 Cat. No.: U408988 Molecular Weight: 475.62 EC Number: 682-170-1 PubChem CID: 130904

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

HRP 2000, RU 44675 | (11β)-11-[4-(dimethylamino)phenyl]-17-hydroxy-19-Norpregna-4,9-diene-3,20-dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selectiveSPRMfor emergency contraception after an unprotected intercourse or contraceptive failure.
In vitro

Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to theglucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.

In vivo

Based on clinical trials, ulipristal acetate seems to be a reasonably tolerable and effective method of emergency contraception when used within 120 hours of intercourse. Ulipristal acetate is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, ulipristal acetate may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for emergency contraception. ^[2][3]
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

HRP 2000, RU 44675 | (11β)-11-[4-(dimethylamino)phenyl]-17-hydroxy-19-Norpregna-4, 9-diene-3, 20-dione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST, ANTAGONIST, MODULATOR

Mechanism of action

Progesterone receptor modulator

Names and Identifiers

• Isomeric SMILES: CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)OC(=O)C
• PubChem CID: 130904
• Molecular Weight: 475.62

Associated Targets(Human)

PGR Tclin Progesterone receptor (3 Activities)

Discover Target: PGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 31 mg/mL (202.42 mM); Ethanol: 31 mg/mL (202.42 mM); Water: Insoluble
• Specific Rotation[α]: 179° (C=1,CHCl3)
• Melt Point(°C): 186 °C