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Umeclidinium bromide - 10mM in DMSO , Muscarinic acetylcholine receptor M3 antagonist, CAS No.869113-09-7, Muscarinic acetylcholine receptor M3 antagonist

CAS: 869113-09-7 Cat. No.: U426492 Molecular Weight: 508.49 EC Number: 638-761-1 PubChem CID: 11519069
COA
Umeclidinium bromide - 10mM in DMSO CAS No(869113-09-7) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Synonyms
AC-24961 | Umeclidinium (bromide) | 7AN603V4JV | bromuro de umeclidinio | EN300-18166815 | Incruse Ellipta | AKOS025404842 | D10181 | TRELEGY ELLIPTA COMPONENT UMECLIDINIUM BROMIDE | umeclidinii bromidum | UMECLIDINIUM BROMIDE COMPONENT OF TRELEGY ELLIPTA
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
U426492-1ml
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).

Targets

mAChR

In vitro

Umeclidinium is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium for the cloned human M1-M5 mAChRs ranged from 0.05 to 0.16 nM.

In vivo

Umeclidinium is a potent anticholinergic agent that demonstrates slow functional reversibility at the human M3 mAChR and long duration of action in animal models.

Specifications

Synonyms
AC-24961 | Umeclidinium (bromide) | 7AN603V4JV | bromuro de umeclidinio | EN300-18166815 | Incruse Ellipta | AKOS025404842 | D10181 | TRELEGY ELLIPTA COMPONENT UMECLIDINIUM BROMIDE | umeclidinii bromidum | UMECLIDINIUM BROMIDE COMPONENT OF TRELEGY ELLIPTA
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Mechanism of action
Muscarinic acetylcholine receptor M3 antagonist
Product Properties
ALogP0.924
Rotatable Bond8
Names and Identifiers
Pubchem Sid528772991
Canonical SmilesC1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5.[Br-]
IUPAC Namediphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol;bromide
InChIKeyPEJHHXHHNGORMP-UHFFFAOYSA-M
INCHI1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25;/h1-15,31H,16-24H2;1H/q+1;/p-1
Isomeric SMILES C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5.[Br-]
PubChem CID 11519069
Molecular Weight 508.49

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassDiphenylmethanes
Intermediate Tree Nodes Not available
Direct ParentDiphenylmethanes
Alternative Parents Benzylethers  Quinuclidines  Aralkylamines  Piperidines  Tetraalkylammonium salts  Tertiary alcohols  Dialkyl ethers  Azacyclic compounds  Organopnictogen compounds  Organic zwitterions  Organic bromide salts  Hydrocarbon derivatives  Aromatic alcohols  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Diphenylmethane - Benzylether - Quinuclidine - Aralkylamine - Piperidine - Tetraalkylammonium salt - Quaternary ammonium salt - Tertiary alcohol - Dialkyl ether - Ether - Azacycle - Organoheterocyclic compound - Organic bromide salt - Hydrocarbon derivative - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic alcohol - Organic zwitterion - Organic salt - Organic nitrogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
DMSO(mg / mL) Max Solubility100
DMSO(mM) Max Solubility196.6607013
Water(mg / mL) Max Solubility＜1
Molecular Weight508.500 g/mol
XLogP3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass507.177 Da
Monoisotopic Mass507.177 Da
Topological Polar Surface Area29.500 Ų
Heavy Atom Count33
Formal Charge0
Complexity543.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Solution Calculators
Reviews

Customer Reviews

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