ZnAF-1F (Zinc Ion Fluorescent Probe) - BioReagent, for Microscopy, for Fluorescence analysis, ≥90%(HPCE) , CAS No.443302-08-7

CAS: 443302-08-7 Cat. No.: Z336324 Summenformel: C₃₄H₂₆F₂N₄O₅ Molekulargewicht: 608.59 PubChem CID: 16218749

GRADE & PURITY BioReagent, for Fluorescence analysis, for Microscopy, ≥90%(HPCE)

Synonyms

DTXSID60585020 | ZnAF-1F, >=90% (HPCE) | ZnAF-1F | 5-({2-[Bis(2-Pyridinylmethyl)Amino]Ethyl}Amino)-2-(2,7-Difluoro-6-Hydroxy-3-Oxo-3H-Xanthen-9-ylBenzoic Acid | 5-[(2-{BIS[(PYRIDIN-2-YL)METHYL]AMINO}ETHYL)AMINO]-2-(2,7-DIFLUORO-6-HYDROXY-3-OXO-3H-XANTHEN-

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Application

Fluorescence Analysis

Übersicht

ZnAF‑1F and ZnAF‑2F do not fluoresce in the presence of other biologically important cations such as Ca²⁺ and Mg²⁺, and are insensitive to change of pH. The complexes with Zn²⁺ of previously developed ZnAFs, ZnAF‑1, and ZnAF‑2 decrease in fluorescence intensity below pH 7.0 owing to protonation of the phenolic hydroxyl group of fluorescein, whose pKa value is 6.2. On the other hand, the Zn²⁺ complexes of ZnAF‑1F and ZnAF‑2F emit stable fluorescence under neutral and slightly acidic conditions because the pKa values are shifted to 4.9 by substitution of electron‑withdrawing fluorine at the ortho position of the phenolic hydroxyl group. Spectral data: λex 492 nm; λem 517 nm in PBS.

Specifications

Synonyme

DTXSID60585020 | ZnAF-1F, >=90% (HPCE) | ZnAF-1F | 5-({2-[Bis(2-Pyridinylmethyl)Amino]Ethyl}Amino)-2-(2,7-Difluoro-6-Hydroxy-3-Oxo-3H-Xanthen-9-ylBenzoic Acid | 5-[(2-{BIS[(PYRIDIN-2-YL)METHYL]AMINO}ETHYL)AMINO]-2-(2,7-DIFLUORO-6-HYDROXY-3-OXO-3H-XANTHEN-

Spezifikationen & Reinheit

BioReagent, for Microscopy, for Fluorescence analysis, ≥90%(HPCE)

Stabilität und Lagerung

Store at -20℃ long term (24 months). Store in the dark. Desiccated.

Storage

Protected from light,Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

BioReagent, für die Fluoreszenzanalyse, für die Mikroskopie

Reinheit

≥90%(HPCE)

Namen und Kennungen

• Kanonisches Lächeln: C1=CC=NC(=C1)CN(CCNC2=CC(=C(C=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)F)O)F)C(=O)O)CC6=CC=CC=N6
• IUPAC Name: 5-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]-2-(2,7-difluoro-3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
• InChIKey: PUDBCJSXTISPOO-UHFFFAOYSA-N
• INCHI: 1S/C34H26F2N4O5/c35-27-14-25-31(16-29(27)41)45-32-17-30(42)28(36)15-26(32)33(25)23-8-7-20(13-24(23)34(43)44)39-11-12-40(18-21-5-1-3-9-37-21)19-22-6-2-4-10-38-22/h1-10,13-17,39,41H,11-12,18-19H2,(H,43,44)
• Isomere SMILES: C1=CC=NC(=C1)CN(CCNC2=CC(=C(C=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)F)O)F)C(=O)O)CC6=CC=CC=N6
• PubChem CID: 16218749
• Molekulargewicht: 608.59

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Benzopyrans
      • Subclass 1-benzopyrans
        • Ebene5 Dibenzopyrans
          • Ebene6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: Aminobenzoic acids Benzoic acids Phenylalkylamines 2-pyridylmethylamines Aniline and substituted anilines O-fluorophenols Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids Secondary alkylarylamines Aryl fluorides Heteroaromatic compounds Cyclic ketones Amino acids Trialkylamines Carboxylic acids Monocarboxylic acids and derivatives Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic oxides Organofluorides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Aminobenzoic acid - Aminobenzoic acid or derivatives - Benzoic acid or derivatives - Benzoic acid - 2-pyridylmethylamine - Benzoyl - 2-fluorophenol - Aniline or substituted anilines - Phenylalkylamine - 1-hydroxy-2-unsubstituted benzenoid - Secondary aliphatic/aromatic amine - Aralkylamine - Benzenoid - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Pyridine - Heteroaromatic compound - Cyclic ketone - Tertiary aliphatic amine - Amino acid - Tertiary amine - Amino acid or derivatives - Secondary amine - Azacycle - Oxacycle - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organofluoride - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organohalogen compound - Organonitrogen compound - Organooxygen compound - Amine - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in DMSO.
• Molekulargewicht: 608.600 g/mol
• XLogP3: 1.500
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 10
• Exact Mass: 608.187 Da
• Monoisotopic Mass: 608.187 Da
• Topological Polar Surface Area: 125.000 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 1170.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1