Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| ALogP | -4.3 |
|---|
| Pubchem Sid | 488184180 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184180 |
| Canonical Smiles | C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O |
| IUPAC Name | (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid |
| InChIKey | XRASPMIURGNCCH-UHFFFAOYSA-N |
| INCHI | 1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14) |
| Isomeric SMILES | C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O |
| PubChem CID | 68740 |
| Molecular Weight | 272.09 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Organic phosphonic acids and derivatives |
| Subclass | Bisphosphonates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Bisphosphonates |
| Alternative Parents | N-substituted imidazoles Organic phosphonic acids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Bisphosphonate - N-substituted imidazole - Heteroaromatic compound - Organophosphonic acid - Imidazole - Azole - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms. |
| External Descriptors | imidazoles - 1,1-bis(phosphonic acid) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jan 04, 2026 | Z129382 | |
| Certificate of Analysis | Jan 04, 2026 | Z129382 | |
| Certificate of Analysis | Jan 04, 2026 | Z129382 | |
| Certificate of Analysis | Jan 04, 2026 | Z129382 | |
| Certificate of Analysis | Jan 04, 2026 | Z129382 | |
| Certificate of Analysis | May 07, 2025 | Z129382 | |
| Certificate of Analysis | May 07, 2025 | Z129382 | |
| Certificate of Analysis | May 07, 2025 | Z129382 | |
| Certificate of Analysis | May 07, 2025 | Z129382 | |
| Certificate of Analysis | May 07, 2025 | Z129382 | |
| Certificate of Analysis | May 07, 2025 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Oct 08, 2024 | Z129382 | |
| Certificate of Analysis | Mar 02, 2024 | Z129382 | |
| Certificate of Analysis | Jul 07, 2023 | Z129382 | |
| Certificate of Analysis | Jul 07, 2023 | Z129382 | |
| Certificate of Analysis | Jul 07, 2023 | Z129382 | |
| Certificate of Analysis | Jul 07, 2023 | Z129382 | |
| Certificate of Analysis | Jul 07, 2023 | Z129382 | |
| Certificate of Analysis | Jan 12, 2023 | Z129382 | |
| Certificate of Analysis | Jan 12, 2023 | Z129382 | |
| Certificate of Analysis | Jan 12, 2023 | Z129382 | |
| Certificate of Analysis | Dec 06, 2022 | Z129382 | |
| Certificate of Analysis | Jul 04, 2022 | Z129382 | |
| Certificate of Analysis | Jun 23, 2022 | Z129382 | |
| Certificate of Analysis | Jun 23, 2022 | Z129382 | |
| Certificate of Analysis | Jan 27, 2022 | Z129382 |
| Solubility | DMSO 0.004 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
|---|---|
| Molecular Weight | 272.090 g/mol |
| XLogP3 | -4.300 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 4 |
| Exact Mass | 271.996 Da |
| Monoisotopic Mass | 271.996 Da |
| Topological Polar Surface Area | 153.000 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 327.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang. (2023) Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis. Journal of the Mechanical Behavior of Biomedical Materials, [PMID:38091923] [10.1016/j.jmbbm.2023.106306] |
| 2. Yao Duan, Chanyuan Jin, Yuwei Wu, Yan Chen, Minjuan Zhang, Jun Qian, Ting Shuai, Jian Li, Huimin Chen, Dan Li. (2023) CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF. TISSUE & CELL, [PMID:37776785] [10.1016/j.tice.2023.102223] |
| 3. Ting Ge, Zhang Weiwei, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Wan Dong, Yugui Tao, Kai Yang. (2022) A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis. Biomaterials Science, 10 (7): (1831-1843). [PMID:35253030] [10.1039/D1BM01717A] |
| 4. Xi Cui, Yizhu Shan, Jiaxuan Li, Meng Xiao, Yuan Xi, Jianying Ji, Engui Wang, Baokun Zhang, Lingling Xu, Mingzhu Zhang, Zhou Li, Yingzi Zhang. (2024) Bifunctional Piezo-Enhanced PLLA/ZA Coating Prevents Aseptic Loosening of Bone Implants. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202403759] |
| 5. Wei Wang, Xing Zhang, Lichen Zhang, Ziang Li, Lingjun Wang, Xinzhao Jiang, Jie Wu, Liang Zhou, Qiangqiang Guo, Yiyang Huang, Wenbo Wang, Kun Xi, Gert Storm, Yong Gu, Liang Chen. (2025) An Immunomodulating Regenerating Hydrogel That Rescues the Oxidative Microenvironment and Reverses Cell Senescence for Osteoporotic Bone Defects. ACS Nano, [PMID:40754989] [10.1021/acsnano.5c06549] |
| 6. Li Luyao, Wang Cheng, Chu Weicun, Park Jaewang, Dai Yiming, Ba Qiankai, Wang Kaifeng, Gao Jiaxing, Wei Zeliang, Zhao Xiaoming, Nie Xuchen, Yin Lixiong, Seok Sang Il, Nie Riming, Guo Wanlin. (2025) Fully chemical interface engineering for statically and dynamically stable perovskite solar cells. Nature Communications, 16 (1): (1-11). [PMID:41022772] [10.1038/s41467-025-63588-8] |
| 7. Min Zhang, Dehui Fan, Wenchang Wu, Lixin Feng, Tong Sun, Hua Yang, Guoqiang Zhou, Jinchao Zhang, Yu Han, Kun Ge. (2025) Bone-targeting single-atom nanozymes for treating breast cancer bone metastasis via the synergistic effect of mild photothermal and chemodynamic therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:40946508] [10.1016/j.jcis.2025.139000] |
| 8. Dehui Fan, Jing Li, Luwei Li, Ming An, Hua Yang, Guoqiang Zhou, Shutao Gao, Massimo Bottini, Jinchao Zhang, Kun Ge. (2024) Phosphate Ion-Responsive and Calcium Peroxide-Based Nanomedicine for Bone-Targeted Treatment of Breast Cancer Bone Metastasis. Advanced Healthcare Materials, [PMID:39109966] [10.1002/adhm.202402216] |
| 9. Fuchao Chu, Zhenxin Wang, Dazhen Zhang, Wenkang Xu, Boyan Huang, Chen Long, Shuo Yang, Xinzhe Qu, Cunjiu Gao, Feng Yuan. (2024) Research on the osteogenic properties of 3D-printed porous titanium alloy scaffolds loaded with Gelma/PAAM-ZOL composite hydrogels. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39038567] [10.1016/j.ijbiomac.2024.134050] |
| 10. Enyang Yao, Yang Li, Kai Deng, Wei He, Milad Ashrafizadeh, João Conde, Liyu Yang. (2025) Folic acid-targeted macrophage membrane-coated carbon quantum dot nanoplatform for dual drug and gene delivery in metastatic osteosarcoma therapy. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.163227] |
| 11. Fu Xiaoxue, Luo Zhenyu, Guo Yuqi, Meng Weikun, Jin Shue, Chen Junyu, Cai Yongrui, Luo Zeyu, Huang Chao, Chen Anjing, Guo Siqin, Chen Maojia, Zhou Zongke, Zeng Weinan. (2025) Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration. Nature Communications, 16 (1): (10275). [PMID:41271711] [10.1038/s41467-025-65165-5] |
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