ZQ 16 - Moligand™, ≥98%(HPLC) , Agonist of GPR84, CAS No.376616-73-8, Agonist of GPR84

CAS: 376616-73-8 Cat. No.: Z287970 Summenformel: C₁₀H₁₆N₂O₂S Molekulargewicht: 228.31 EG-Nummer: 110-703-5 PubChem CID: 1912564

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone | ZQ-16

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyme

2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone | ZQ-16

Spezifikationen & Reinheit

Moligand™, ≥98%(HPLC)

Biochemische und physiologische Mechanismen

Selective medium-chain free fatty acid receptor GPR84 agonist (EC50= 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desens

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

AGONIST

Mechanismus der Wirkung

Agonist of GPR84

Reinheit

≥98%(HPLC)

Namen und Kennungen

Pubchem Sid

504760652

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504760652

Kanonisches Lächeln

CCCCCCSC1=NC(=CC(=O)N1)O

IUPAC Name

2-hexylsulfanyl-4-hydroxy-1H-pyrimidin-6-one

InChIKey

UYXOAKRMLQKLQX-UHFFFAOYSA-N

INCHI

1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)

Isomere SMILES

CCCCCCSC1=NC(=CC(=O)N1)O

PubChem CID

1912564

MeSH-Eintrag

2-(hexylthio)pyrimidine-4,6-diol;ZA-16 compound

Molekulargewicht

228.31

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organosulfur compounds
    • Klasse Thioethers
      • Subclass Aryl thioethers

• Kingdom: Organic compounds
• Superclass: Organosulfur compounds
• Klasse: Thioethers
• Subclass: Aryl thioethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Aryl thioethers
• Alternative Parents: Pyrimidones Hydroxypyrimidines Alkylarylthioethers Hydropyrimidines Vinylogous acids Heteroaromatic compounds Lactams Sulfenyl compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aryl thioether - Pyrimidone - Hydroxypyrimidine - Alkylarylthioether - Hydropyrimidine - Pyrimidine - Heteroaromatic compound - Vinylogous acid - Lactam - Sulfenyl compound - Azacycle - Organoheterocyclic compound - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as aryl thioethers. These are organosulfur compounds containing a thioether group that is substituted by an aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

GPR84 Tchem G-protein coupled receptor 84 (5 Activities)

Discover Target: GPR84

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 11.42, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 22.83, Max Conc. mM: 100
• Molekulargewicht: 228.310 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 228.093 Da
• Monoisotopic Mass: 228.093 Da
• Topological Polar Surface Area: 87.000 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 287.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 376616-73-8, the molecular formula is C10H16N2O2S, and the molecular weight is 228.31 g/mol. InChIKey UYXOAKRMLQKLQX-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.