CaSR

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  1. NPS-2143, Allosteric modulator of CaS receptor;Allosteric modulator of GPRC6 receptor;Allosteric modulator of mGlu 5 receptor
    CAS: 284035-33-2 Formula: C24H25ClN2O2 Molecular Weight: 408.93
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: N422994
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    Technical Identifiers
    IUPAC Name
    2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
    SMILES
    CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O
    InChIKey
    PZUJQWHTIRWCID-HXUWFJFHSA-N
    InChI
    1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
    Synonyms
    AC-26854 | GTPL716 | EX-A017 | L-Phe-OMe.HCl | SW219455-1 | BCP02421 | YP1 | 2-Chloro-6-[((2R)-3-([1,1-dimethyl-2-(2-...
  2. Strontium ranelate
    CAS: 135459-87-9 EC Number: 690-882-9 PubChem CID: 6918182 Formula: C12H6N2O8SSr2 Molecular Weight: 513.49
    ● In Stock — US warehouse, ships to EU* Item #: S275939
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    IUPAC Name
    distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate
    SMILES
    C(C1=C(SC(=C1C#N)N(CC(=O)[O-])CC(=O)[O-])C(=O)[O-])C(=O)[O-].[Sr+2].[Sr+2]
    InChIKey
    XXUZFRDUEGQHOV-UHFFFAOYSA-J
    InChI
    1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4
    Synonyms
    AKOS015900462 | S 12911 | 04NQ160FRU | Protelos | MFCD00899604 | 5-(BIS(CARBOXYMETHYL)AMINO)-2-CARBOXY-4-CYANO-3-THIO...
  3. Poly-D-lysine hydrobromide
    CAS: 27964-99-4 EC Number: 959-037-4 PubChem CID: 87493163 Formula: D-Lys-(D-Lys)n-D-Lys·xHBr
    Solid Molecular weight ≥ 300000
    ● In Stock — US warehouse, ships to EU* Item #: P477773
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    Technical Identifiers
    IUPAC Name
    (2R)-2,6-diaminohexanoic acid;hydrobromide
    SMILES
    C(CCN)CC(C(=O)O)N.Br
    InChIKey
    MEXAGTSTSPYCEP-NUBCRITNSA-N
    InChI
    1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
    Synonyms
    PDL
  4. Poly-D-lysine hydrobromide
    CAS: 27964-99-4 PubChem CID: 87493163 Formula: D-Lys-(D-Lys)n-D-Lys·xHBr
    average MW 6300
    ◐ .Made to order · 8–12 wks Item #: P477778
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    Technical Identifiers
    IUPAC Name
    (2R)-2,6-diaminohexanoic acid;hydrobromide
    SMILES
    C(CCN)CC(C(=O)O)N.Br
    InChIKey
    MEXAGTSTSPYCEP-NUBCRITNSA-N
    InChI
    1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
    Synonyms
    D-Lysine homopolymer hydrobromide
  5. Poly-D-lysine hydrobromide
    CAS: 27964-99-4 PubChem CID: 87493163 Formula: D-Lys-(D-Lys)n-D-Lys·xHBr
    Mw 30000-70000
    ● In Stock — US warehouse, ships to EU* Item #: P477795
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    Technical Identifiers
    IUPAC Name
    (2R)-2,6-diaminohexanoic acid;hydrobromide
    SMILES
    C(CCN)CC(C(=O)O)N.Br
    InChIKey
    MEXAGTSTSPYCEP-NUBCRITNSA-N
    InChI
    1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
    Synonyms
    PDL
  6. Poly-D-lysine hydrobromide
    CAS: 27964-99-4 PubChem CID: 87493163 Formula: D-Lys-(D-Lys)n-D-Lys·xHBr
    average MW 10000
    ◐ .Made to order · 8–12 wks Item #: P477799
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    Technical Identifiers
    IUPAC Name
    (2R)-2,6-diaminohexanoic acid;hydrobromide
    SMILES
    C(CCN)CC(C(=O)O)N.Br
    InChIKey
    MEXAGTSTSPYCEP-NUBCRITNSA-N
    InChI
    1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
    Synonyms
    D-Lysine homopolymer hydrobromide
  7. Poly-D-lysine hydrobromide
    CAS: 27964-99-4 PubChem CID: 87493163 Formula: D-Lys-(D-Lys)n-D-Lys·xHBr
    Mn~84000 Da by NMR (equivalent to Mw 150-300 kDa by viscosity )
    ● In Stock — US warehouse, ships to EU* Item #: P477809
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    Technical Identifiers
    IUPAC Name
    (2R)-2,6-diaminohexanoic acid;hydrobromide
    SMILES
    C(CCN)CC(C(=O)O)N.Br
    InChIKey
    MEXAGTSTSPYCEP-NUBCRITNSA-N
    InChI
    1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
  8. Cinacalcet, Allosteric modulator of CaS receptor;Allosteric modulator of mGlu 5 receptor
    CAS: 226256-56-0 EC Number: 682-701-7 Formula: C22H22F3N Molecular Weight: 357.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C125075
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    Technical Identifiers
    IUPAC Name
    N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
    SMILES
    CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
    InChIKey
    VDHAWDNDOKGFTD-MRXNPFEDSA-N
    InChI
    1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1
    Synonyms
    KRN1493 | KRN-1493 | Cinacalcet (USAN) | s5191 | AB01274759_02 | D92228 | N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluor...
  9. Poly(D-lysine hydrobromide
    CAS: 27964-99-4 PubChem CID: 87493163 Formula: D-Lys-(D-Lys)n-D-Lys·xHBr
    ◐ .Made to order · 8–12 wks Item #: P489854
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (2R)-2,6-diaminohexanoic acid;hydrobromide
    SMILES
    C(CCN)CC(C(=O)O)N.Br
    InChIKey
    MEXAGTSTSPYCEP-NUBCRITNSA-N
    InChI
    1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
  10. evocalcet, Calcium sensing receptor positive allosteric modulator
    CAS: 870964-67-3 EC Number: 887-622-3 PubChem CID: 71242808 Formula: C24H26N2O2 Molecular Weight: 374.48
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: E610229
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    Technical Identifiers
    IUPAC Name
    2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid
    SMILES
    CC(C1=CC=CC2=CC=CC=C21)NC3CCN(C3)C4=CC=C(C=C4)CC(=O)O
    InChIKey
    RZNUIYPHQFXBAN-XLIONFOSSA-N
    InChI
    1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/mshow more
    Synonyms
    LMPK12110188 | DTXSID101132784 | EVOCALCET [MI] | (4-((3S)-3-(((1R)-1-(1-Naphthyl)ethyl)amino)-1-pyrrolidinyl)phenyl)...
  11. upacicalcet, Allosteric modulator of CaS receptor
    CAS: 1333218-50-0 PubChem CID: 53374467
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: U614667
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    Technical Identifiers
    IUPAC Name
    (2S)-2-amino-3-[(3-chloro-2-methyl-5-sulfophenyl)carbamoylamino]propanoic acid
    SMILES
    Cc1c(cc(cc1Cl)S(=O)(=O)O)NC(=O)NC[C@@H](C(=O)O)N
    InChIKey
    LHEYGVSDVBEYQF-QMMMGPOBSA-N
    InChI
    1S/C11H14ClN3O6S/c1-5-7(12)2-6(22(19,20)21)3-9(5)15-11(18)14-4-8(13)10(16)17/h2-3,8H,4,13H2,1H3,(H,16,17)(H2,14,15,18)(H,19,20,21)/t8-/m0/s1
    Synonyms
    5C1222PBE2 | upasita | (2S)-2-amino-3-{[(3-chloro-2-methyl-5-sulfophenyl)carbamoyl]amino}propanoic acid | GLXC-26510 ...
  12. tecalcet, Allosteric modulator of CaS receptor
    CAS: 148717-54-8 PubChem CID: 158797
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: T614365
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    Technical Identifiers
    IUPAC Name
    3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
    SMILES
    CC(C1=CC(=CC=C1)OC)NCCCC2=CC=CC=C2Cl
    InChIKey
    ZVQUCWXZCKWZBP-CQSZACIVSA-N
    InChI
    1S/C18H22ClNO/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3/t14-/m1/s1
    Synonyms
    (r)-N-(3-methoxy-alpha-phenylethyl) -3-(2-chlorophenyl)-1-propylamine | R 568 | NPS-R568 | NPS-R-568 | 8I16YLE4US | Q...
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Frequently Asked Questions

How is the CaSR listing put together?
It draws on reported CaSR annotations within GPCR/G Protein and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a CaSR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the CaSR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for CaSR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For CaSR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the CaSR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of CaSR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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