DNA Alkylator/Crosslinker

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  1. N-Nitrosodimethylamine
    CAS: 62-75-9 EC Number: 200-549-8 Formula: C2H6N2O Molecular Weight: 74.08
    Liquid ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: N396014
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    IUPAC Name
    N,N-dimethylnitrous amide
    SMILES
    CN(C)N=O
    InChIKey
    UMFJAHHVKNCGLG-UHFFFAOYSA-N
    InChI
    1S/C2H6N2O/c1-4(2)3-5/h1-2H3
    Synonyms
    N-NITROSODIMETHYLAMINE|Dimethylnitrosamine|62-75-9|NDMA|N-Methyl-N-nitrosomethanamine|Dimethylnitrosoamine|N,N-Dimeth...
  2. N-Succinimidyl 4-(p-Maleimidophenyl)butyrate
    CAS: 79886-55-8 Formula: C18H16N2O6 Molecular Weight: 356.33
    Solid ≥97%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: N137694
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    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 4-[4-(2,5-dioxopyrrol-1-yl)phenyl]butanoate
    SMILES
    C1CC(=O)N(C1=O)OC(=O)CCCC2=CC=C(C=C2)N3C(=O)C=CC3=O
    InChIKey
    PMJWDPGOWBRILU-UHFFFAOYSA-N
    InChI
    1S/C18H16N2O6/c21-14-8-9-15(22)19(14)13-6-4-12(5-7-13)2-1-3-18(25)26-20-16(23)10-11-17(20)24/h4-9H,1-3,10-11H2
    Synonyms
    MFCD00054961 | NSC 344484 | N-Succinimidyl 4-(4-maleimidophenyl)butyrate | N-Succinimidyl 4-[4-maleimidophenyl]butyra...
  3. RITA (NSC 652287)
    CAS: 213261-59-7 PubChem CID: 374536 Formula: C14H12O3S2 Molecular Weight: 292.37
    ● In Stock — US warehouse, ships to EU* Item #: R125421
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    IUPAC Name
    [5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
    SMILES
    C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
    InChIKey
    KZENBFUSKMWCJF-UHFFFAOYSA-N
    InChI
    1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
    Synonyms
    BCP06744 | J-504944 | FT-0703160 | HMS3269E07 | [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methan...
  4. Satraplatin
    CAS: 129580-63-8 Formula: C10H24Cl2N2O4Pt Molecular Weight: 500.28
    ◐ .Made to order · 8–12 wks Item #: S275792
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    SMILES
    CC(=O)O.CC(=O)O.C1CCC(CC1)N.N.Cl[Pt]Cl
    Synonyms
    Bis-acetatoamminedichlorocyclohexylamineplatinum(iv)
  5. Ifosfamide
    CAS: 3778-73-2 EC Number: 223-237-3 Formula: C7H15Cl2N2O2P Molecular Weight: 261.09
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. Pharmaceutical grade ? Pharmaceutical grade — purity and documentation suitable for drug applications. Use for API/excipient work requiring pharma-level quality and traceability.
    ● In Stock — US warehouse, ships to EU* Item #: I123381
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    IUPAC Name
    N,3-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
    SMILES
    C1CN(P(=O)(OC1)NCCCl)CCCl
    InChIKey
    HOMGKSMUEGBAAB-UHFFFAOYSA-N
    InChI
    1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
    Synonyms
    Ifosfamide [USAN:USP:INN:BAN:JAN] | Ifosfamidum (INN-Latin) | NCGC00016639-01 | Prestwick3_000833 | IFEX (TN) | Ifosf...
  6. Ifosfamide, DNA inhibitor
    CAS: 3778-73-2 EC Number: 223-237-3 Formula: C7H15Cl2N2O2P Molecular Weight: 261.09
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: I123242
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    IUPAC Name
    N,3-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
    SMILES
    C1CN(P(=O)(OC1)NCCCl)CCCl
    InChIKey
    HOMGKSMUEGBAAB-UHFFFAOYSA-N
    InChI
    1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
    Synonyms
    Ifosfamide [USAN:USP:INN:BAN:JAN] | Ifosfamidum (INN-Latin) | NCGC00016639-01 | Prestwick3_000833 | IFEX (TN) | Ifosf...
  7. Streptozocin, DNA inhibitor
    CAS: 18883-66-4 EC Number: 242-646-8 Formula: C8H15N3O7 Molecular Weight: 265.22
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% mixture of isomers
    ● In Stock — US warehouse, ships to EU* Item #: S110910
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    IUPAC Name
    1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
    SMILES
    CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
    InChIKey
    ZSJLQEPLLKMAKR-GKHCUFPYSA-N
    InChI
    1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
    Synonyms
    STZ | N-(Methylnitrosocarbamoyl)-α-D-glucosamine | Streptozotocin
  8. Illudin S
    CAS: 1149-99-1 Formula: C15H20O4 Molecular Weight: 264.32
    Solid ≥98%
    ◐ .Made to order · 8–12 wks Item #: I329464
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    IUPAC Name
    (1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
    SMILES
    CC1=C2C(C(C=C2C(=O)C(C13CC3)(C)O)(C)CO)O
    InChIKey
    DDLLIYKVDWPHJI-RDBSUJKOSA-N
    InChI
    1S/C15H20O4/c1-8-10-9(6-13(2,7-16)12(10)18)11(17)14(3,19)15(8)4-5-15/h6,12,16,18-19H,4-5,7H2,1-3H3/t12-,13+,14+/m1/s1
    Synonyms
    (2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7...
  9. KCC 07
    CAS: 315702-75-1 Formula: C14H11N3OS Molecular Weight: 269.32
    ● In Stock — US warehouse, ships to EU* Item #: K288208
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    IUPAC Name
    3-[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]phenol
    SMILES
    C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC(=CC=C3)O
    InChIKey
    GIGNWEDIMLUWCT-UHFFFAOYSA-N
    InChI
    1S/C14H11N3OS/c18-11-5-3-4-10(8-11)16-14-17-13(9-19-14)12-6-1-2-7-15-12/h1-9,18H,(H,16,17)
    Synonyms
    3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol | KCC-07
  10. Temozolomide, DNA inhibitor
    CAS: 85622-93-1 EC Number: 630-358-9 PubChem CID: 5394 Formula: C6H6N6O2 Molecular Weight: 194.15
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: T127425
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    IUPAC Name
    3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
    SMILES
    CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
    InChIKey
    BPEGJWRSRHCHSN-UHFFFAOYSA-N
    InChI
    1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
    Synonyms
    4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide | CCRG 81045 | NSC 362856 | TMZ | 3,4-D...
  11. Tri(1-aziridinyl)phosphine sulfide, DNA inhibitor
    CAS: 52-24-4 EC Number: 200-135-7 PubChem CID: 5453 Formula: C6H12N3PS Molecular Weight: 189.22
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: T123963
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    IUPAC Name
    tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane
    SMILES
    C1CN1P(=S)(N2CC2)N3CC3
    InChIKey
    FOCVUCIESVLUNU-UHFFFAOYSA-N
    InChI
    1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
    Synonyms
    Thioplex (TN) (Immunex) | Tifosyl | EINECS 200-135-7 | HSDB 3258 | N,N',N''-Triethylenephosphorothioic triamide | Tio...
  12. Nimustine Hydrochloride
    CAS: 55661-38-6 Formula: C9H13ClN6O2·HCl Molecular Weight: 309.15
    ● In Stock — US warehouse, ships to EU* Item #: N159515
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    IUPAC Name
    3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea;hydrochloride
    SMILES
    CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O.Cl
    InChIKey
    KPMKNHGAPDCYLP-UHFFFAOYSA-N
    InChI
    1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H
    Synonyms
    BN164659 | Nidran (TN) | N'-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitrosourea HCl | Nidran hyd...
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Frequently Asked Questions

Which compounds are listed for DNA Alkylator/Crosslinker?
Compounds associated with DNA Alkylator/Crosslinker are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does DNA Alkylator/Crosslinker sit within Cell Cycle/DNA Damage?
DNA Alkylator/Crosslinker is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from DNA Alkylator/Crosslinker?
For compounds listed under DNA Alkylator/Crosslinker, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for DNA Alkylator/Crosslinker?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring DNA Alkylator/Crosslinker, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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