Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.
JAK/STAT Signaling
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- Abrocitinib (PF-04965842), Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A421972View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
- SMILES
- CCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3
- InChIKey
- IUEWXNHSKRWHDY-UHFFFAOYSA-N
- InChI
- 1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)
- Synonyms
- Abrocitinib;N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide | N-(3-(Methyl(7H-...
- AfatinibCAS: 439081-18-2 Formula: C24H25ClFN5O3 Molecular Weight: 485.9410mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A423984View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
- InChIKey
- ULXXDDBFHOBEHA-CWDCEQMOSA-N
- InChI
- show more
- Synonyms
- BIBW2992 | (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-en...
- Afatinib dimaleate, Receptor protein-tyrosine kinase erbB-4 inhibitorCAS: 850140-73-7 EC Number: 810-416-1 PubChem CID: 15606394 Formula: C32H33ClFN5O11 Molecular Weight: 718.0810mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A426249View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (Z)-but-2-enedioic acid;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
- InChIKey
- USNRYVNRPYXCSP-JUGPPOIOSA-N
- InChI
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- Synonyms
- BIBW2992 DiMaleate | (2E)-N-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-...
- AfatinibCAS: 439081-18-2 Formula: C24H25ClFN5O3 Molecular Weight: 485.94Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: A401422View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
- InChIKey
- ULXXDDBFHOBEHA-CWDCEQMOSA-N
- InChI
- show more
- Synonyms
- (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide | AFA...
- AlantolactoneCAS: 546-43-0 Formula: C15H20O2 Molecular Weight: 232.3210mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A424655View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-5,6,7,8,9,9a-hexahydro-3aH-benzo[f][1]benzofuran-2-one
- SMILES
- CC1CCCC2(C1=CC3C(C2)OC(=O)C3=C)C
- InChIKey
- PXOYOCNNSUAQNS-AGNJHWRGSA-N
- InChI
- 1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1
- Synonyms
- (3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one | Q21099633 | DT...
- Alflutinib (AST2818) mesylate● In Stock — US warehouse, ships to EU* Item #: A413662View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(N=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OCC(F)(F)F.CS(=O)(=O)O
- InChIKey
- WDPGHXINXNBHAS-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- C29H35F3N8O5S | EX-A2864 | 2130958-55-1 | Furmonertinib mesylate | ALFLUTINIB MESILATE | AC-35567 | Alflutinib mesyla...
- Alflutinib (AST2818) mesylate10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A422285View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- show more
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(N=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OCC(F)(F)F.CS(=O)(=O)O
- InChIKey
- WDPGHXINXNBHAS-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- C29H35F3N8O5S | EX-A2864 | 2130958-55-1 | Furmonertinib mesylate | ALFLUTINIB MESILATE | AC-35567 | Alflutinib mesyla...
- Astaxanthin, Antioxidant, anti-inflammatory and antiapoptotic activities10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A424114View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C
- InChIKey
- MQZIGYBFDRPAKN-UWFIBFSHSA-N
- InChI
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- Synonyms
- DTXSID00893777 | Natupink | UNII-8XPW32PR7I | .beta.-Carotene-4,4'-dione, 3,3'-dihydroxy-, all-trans- | BCP05821 | CH...
- Atiprimod dihydrochloride◐ .Made to order · 8–12 wks Item #: A288614View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine;dihydrochloride
- SMILES
- CCCC1(CCC2(CC1)CCN(C2)CCCN(CC)CC)CCC.Cl.Cl
- InChIKey
- MOUZYBYTICOTFQ-UHFFFAOYSA-N
- InChI
- 1S/C22H44N2.2ClH/c1-5-10-21(11-6-2)12-14-22(15-13-21)16-19-24(20-22)18-9-17-23(7-3)8-4;;/h5-20H2,1-4H3;2*1H
- Synonyms
- Atiprimod dihydrochloride (USAN) | Atiprimod dihydrochloride [USAN] | SKF 1006615-A2 | Atiprimoddihydrochloride | Ati...
- Atopaxar, Proteinase-activated receptor 1 antagonistCAS: 751475-53-3 Formula: C29H38FN3O5 Molecular Weight: 527.63Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: A412332View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 1-(3-tert-butyl-4-methoxy-5-morpholin-4-ylphenyl)-2-(5,6-diethoxy-4-fluoro-3-imino-1H-isoindol-2-yl)ethanone
- SMILES
- CCOC1=C(C(=C2C(=C1)CN(C2=N)CC(=O)C3=CC(=C(C(=C3)N4CCOCC4)OC)C(C)(C)C)F)OCC
- InChIKey
- QWKAUGRRIXBIPO-UHFFFAOYSA-N
- InChI
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- Synonyms
- Atopaxar (USAN) | NCGC00346938-03 | 1-(3-(tert-butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoi...
- Atractylenolide ICAS: 73069-13-3 Formula: C15H18O2 Molecular Weight: 230.310mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A425701View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (4aS,8aS)-3,8a-dimethyl-5-methylidene-4a,6,7,8-tetrahydro-4H-benzo[f][1]benzofuran-2-one
- SMILES
- CC1=C2CC3C(=C)CCCC3(C=C2OC1=O)C
- InChIKey
- ZTVSGQPHMUYCRS-SWLSCSKDSA-N
- InChI
- 1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1
- Synonyms
- HMS3886N08 | Atractylenolide I | Atractylenolide I, >=98% (HPLC) | s8291 | (4aS,8aS)-3,8a-dimethyl-5-methylene-4a,5,6...
- Atractylenolide IICAS: 73069-14-4 Formula: C15H20O2 Molecular Weight: 232.3210mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A425702View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (4aS,8aR,9aS)-3,8a-dimethyl-5-methylidene-4a,6,7,8,9,9a-hexahydro-4H-benzo[f][1]benzofuran-2-one
- SMILES
- CC1=C2CC3C(=C)CCCC3(CC2OC1=O)C
- InChIKey
- OQYBLUDOOFOBPO-KCQAQPDRSA-N
- InChI
- 1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h12-13H,1,4-8H2,2-3H3/t12-,13-,15+/m0/s1
- Synonyms
- Asterolide | HY-N0202 | MFCD09037396 | BDBM50241946 | CHEBI:182501 | Atractylenolide II | AS-76824 | C17886 | Q633984...
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].