JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

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  1. SC99
    CAS: 882290-02-0 PubChem CID: 5896323 Formula: C15H8Cl2FN3O Molecular Weight: 336.15
    ● In Stock — US warehouse, ships to EU* Item #: S412698
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    IUPAC Name
    (1E)-N-(3-chloro-4-fluoroanilino)-2-(4-chlorophenyl)-2-oxoethanimidoyl cyanide
    SMILES
    C1=CC(=CC=C1C(=O)C(=NNC2=CC(=C(C=C2)F)Cl)C#N)Cl
    InChIKey
    ZKULFSMYRSFHKE-KGENOOAVSA-N
    InChI
    1S/C15H8Cl2FN3O/c16-10-3-1-9(2-4-10)15(22)14(8-19)21-20-11-5-6-13(18)12(17)7-11/h1-7,20H/b21-14+
    Synonyms
    N'-(3-Chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
  2. SH-4-54
    CAS: 1456632-40-8 PubChem CID: 72188643 Formula: C29H27F5N2O5S  Molecular Weight: 610.59
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S421680
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    IUPAC Name
    4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
    SMILES
    CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
    InChIKey
    VFPYGNNOSJWBHF-UHFFFAOYSA-N
    InChI
    1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-show more
    Synonyms
    4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid
  3. SH-4-54
    CAS: 1456632-40-8 PubChem CID: 72188643 Formula: C29H27F5N2O5S  Molecular Weight: 610.59
    ● In Stock — US warehouse, ships to EU* Item #: S413742
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    IUPAC Name
    4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
    SMILES
    CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
    InChIKey
    VFPYGNNOSJWBHF-UHFFFAOYSA-N
    InChI
    1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-show more
    Synonyms
    4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid
  4. SH5-07 (SH-5-07)
    CAS: 1456632-41-9 PubChem CID: 72550504 Formula: C29H28F5N3O5S Molecular Weight: 625.61
    ● In Stock — US warehouse, ships to EU* Item #: S413872
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    IUPAC Name
    4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-N-hydroxybenzamide
    SMILES
    CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)NO)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
    InChIKey
    QPSUYVALAOXFGL-UHFFFAOYSA-N
    InChI
    1S/C29H28F5N3O5S/c1-36(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)16-22(38)37(21-13-11-20(12-14-21)29(39)35-40)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/show more
    Synonyms
    BCP18388 | BDBM50446145 | SH5 07 | DTXSID501105537 | SCHEMBL16766371 | SH5-07 (SH-5-07) | 1456632-41-9 | BCP19924 | 4...
  5. SH5-07 (SH-5-07)
    CAS: 1456632-41-9 PubChem CID: 72550504 Formula: C29H28F5N3O5S Molecular Weight: 625.61
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S421681
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    Technical Identifiers
    IUPAC Name
    4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-N-hydroxybenzamide
    SMILES
    CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)NO)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
    InChIKey
    QPSUYVALAOXFGL-UHFFFAOYSA-N
    InChI
    1S/C29H28F5N3O5S/c1-36(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)16-22(38)37(21-13-11-20(12-14-21)29(39)35-40)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/show more
    Synonyms
    BCP18388 | BDBM50446145 | SH5 07 | DTXSID501105537 | SCHEMBL16766371 | SH5-07 (SH-5-07) | 1456632-41-9 | BCP19924 | 4...
  6. SMI-16a
    CAS: 587852-28-6 PubChem CID: 25102785 Formula: C13H13NO3S Molecular Weight: 263.31
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S413485
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    Technical Identifiers
    IUPAC Name
    (5E)-5-[(4-propoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
    SMILES
    CCCOC1=CC=C(C=C1)C=C2C(=O)NC(=O)S2
    InChIKey
    GBWOSXZUTXXXQF-DHZHZOJOSA-N
    InChI
    1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)/b11-8+
    Synonyms
    2,​4-​Thiazolidinedione,5-​[(4-​propoxyphenyl)​methylene]​-
  7. SMI-16a
    CAS: 587852-28-6 PubChem CID: 25102785 Formula: C13H13NO3S Molecular Weight: 263.31
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S424917
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    Technical Identifiers
    IUPAC Name
    (5E)-5-[(4-propoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
    SMILES
    CCCOC1=CC=C(C=C1)C=C2C(=O)NC(=O)S2
    InChIKey
    GBWOSXZUTXXXQF-DHZHZOJOSA-N
    InChI
    1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)/b11-8+
    Synonyms
    2,​4-​Thiazolidinedione,5-​[(4-​propoxyphenyl)​methylene]​-
  8. STAT3-IN-1
    CAS: 2059952-75-7 PubChem CID: 134130166 Formula: C28H29NO6 Molecular Weight: 475.53
    ● In Stock — US warehouse, ships to EU* Item #: S412567
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    IUPAC Name
    (E)-N-[4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
    SMILES
    COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)NC(=O)C=CC3=CC(=C(C(=C3)OC)OC)OC)OC
    InChIKey
    KOZAEBHIXYBHKA-FCXQYMQBSA-N
    InChI
    1S/C28H29NO6/c1-31-23-14-20(15-24(18-23)32-2)7-6-19-8-11-22(12-9-19)29-27(30)13-10-21-16-25(33-3)28(35-5)26(17-21)34-4/h6-18H,1-5H3,(H,29,30)/b7-6+,13show more
    Synonyms
    2-​Propenamide,N-​[4-​[(1E)​-​2-​(3,​5-​dimethoxyphenyl)​ethenyl]​phenyl]​-​3-​(3,​4,​5-​trimethoxyphenyl)​-​,(2E)​-
  9. SU-5402 (DMSO solution)
    CAS: 215543-92-3 Formula: C17H16N2O3 Molecular Weight: 296.32
    Liquid 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S422593
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    Technical Identifiers
    IUPAC Name
    3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
    SMILES
    CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
    InChIKey
    JNDVEAXZWJIOKB-JYRVWZFOSA-N
    InChI
    1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
    Synonyms
    HY-10407G | BCPP000060 | SCHEMBL177917 | SU 5402 | su5402 | SU-5402 | (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)meth...
  10. SU5204
    CAS: 186611-11-0 PubChem CID: 6509031 Formula: C17H15NO2 Molecular Weight: 265.31
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S422280
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    Technical Identifiers
    IUPAC Name
    (3Z)-3-[(2-ethoxyphenyl)methylidene]-1H-indol-2-one
    SMILES
    CCOC1=CC=CC=C1C=C2C3=CC=CC=C3NC2=O
    InChIKey
    MEZFKCPUSMBMAY-KAMYIIQDSA-N
    InChI
    1S/C17H15NO2/c1-2-20-16-10-6-3-7-12(16)11-14-13-8-4-5-9-15(13)18-17(14)19/h3-11H,2H2,1H3,(H,18,19)/b14-11-
    Synonyms
    2H-​Indol-​2-​one,3-​[(2-​ethoxyphenyl)​methylene]​-​1,​3-​dihydro-
  11. STAT3-IN-1
    CAS: 2059952-75-7 PubChem CID: 134130166 Formula: C28H29NO6 Molecular Weight: 475.53
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S422501
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (E)-N-[4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
    SMILES
    COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)NC(=O)C=CC3=CC(=C(C(=C3)OC)OC)OC)OC
    InChIKey
    KOZAEBHIXYBHKA-FCXQYMQBSA-N
    InChI
    1S/C28H29NO6/c1-31-23-14-20(15-24(18-23)32-2)7-6-19-8-11-22(12-9-19)29-27(30)13-10-21-16-25(33-3)28(35-5)26(17-21)34-4/h6-18H,1-5H3,(H,29,30)/b7-6+,13show more
    Synonyms
    2-​Propenamide,N-​[4-​[(1E)​-​2-​(3,​5-​dimethoxyphenyl)​ethenyl]​phenyl]​-​3-​(3,​4,​5-​trimethoxyphenyl)​-​,(2E)​-
  12. SU5204
    CAS: 186611-11-0 PubChem CID: 6509031 Formula: C17H15NO2 Molecular Weight: 265.31
    ≥98% EZ tautomeric mixture
    ● In Stock — US warehouse, ships to EU* Item #: S412303
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    Technical Identifiers
    IUPAC Name
    (3Z)-3-[(2-ethoxyphenyl)methylidene]-1H-indol-2-one
    SMILES
    CCOC1=CC=CC=C1C=C2C3=CC=CC=C3NC2=O
    InChIKey
    MEZFKCPUSMBMAY-KAMYIIQDSA-N
    InChI
    1S/C17H15NO2/c1-2-20-16-10-6-3-7-12(16)11-14-13-8-4-5-9-15(13)18-17(14)19/h3-11H,2H2,1H3,(H,18,19)/b14-11-
    Synonyms
    2H-​Indol-​2-​one,3-​[(2-​ethoxyphenyl)​methylene]​-​1,​3-​dihydro-
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].

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