SC99 - ≥98% , CAS No.882290-02-0

CAS: 882290-02-0 Cat. No.: S412698 Molecular Weight: 336.15 PubChem CID: 5896323

GRADE & PURITY ≥98%

Synonyms

N'-(3-Chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

SC99 is an orally active, selective inhibitor of STAT3 that docks into the ATP-binding pocket of JAK2 and inhibits phosphorylation of JAK2 and STAT3. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities.

Specifications

Synonyms

N'-(3-Chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

SC99 is an orally active, selective inhibitor of STAT3 that docks into the ATP-binding pocket of JAK2 and inhibits phosphorylation of JAK2 and STAT3. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1=CC(=CC=C1C(=O)C(=NNC2=CC(=C(C=C2)F)Cl)C#N)Cl
• IUPAC Name: (1E)-N-(3-chloro-4-fluoroanilino)-2-(4-chlorophenyl)-2-oxoethanimidoyl cyanide
• InChIKey: ZKULFSMYRSFHKE-KGENOOAVSA-N
• INCHI: 1S/C15H8Cl2FN3O/c16-10-3-1-9(2-4-10)15(22)14(8-19)21-20-11-5-6-13(18)12(17)7-11/h1-7,20H/b21-14+
• Isomeric SMILES: C1=CC(=CC=C1C(=O)/C(=N/NC2=CC(=C(C=C2)F)Cl)/C#N)Cl
• PubChem CID: 5896323
• Molecular Weight: 336.15

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Phenylhydrazines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Phenylhydrazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylhydrazines
• Alternative Parents: Benzoyl derivatives Aryl ketones Fluorobenzenes Chlorobenzenes Aryl fluorides Aryl chlorides Nitriles Hydrazones Organopnictogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzoyl - Phenylhydrazine - Aryl ketone - Chlorobenzene - Fluorobenzene - Halobenzene - Aryl halide - Aryl chloride - Aryl fluoride - Ketone - Hydrazone - Carbonitrile - Nitrile - Organic oxide - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Plasmodium berghei (192651 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Light sensitive