Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.
JAK/STAT Signaling
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- CRT 0066101, Inhibitor of protein kinase D1;Inhibitor of protein kinase D2;Inhibitor of protein kinase D3Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: C609605View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-[4-[[(2R)-2-aminobutyl]amino]pyrimidin-2-yl]-4-(1-methylpyrazol-4-yl)phenol
- SMILES
- CCC(CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N
- InChIKey
- SCJXQZZYGYLKJG-CQSZACIVSA-N
- InChI
- 1S/C18H22N6O/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23)/t14-/m1/s1
- Synonyms
- (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol | 2-[4-[[(2R)-2-Aminobutyl]amino]pyr...
- JAK3 inhibitor VI, Inhibitor of leucine rich repeat kinase 2CAS: 454234-24-3 PubChem CID: 9947841Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: J611223View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (3Z)-5-(pyridin-3-yl)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one; methanesulfonic acid
- SMILES
- O=C1Nc2c(/C/1=C/c1ccc[nH]1)cc(cc2)c1cccnc1
- InChIKey
- IQNTXIMXKCURDC-YBEGLDIGSA-N
- InChI
- 1S/C18H13N3O/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13/h1-11,20H,(H,21,22)/b16-10-
- Synonyms
- 2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-, (3Z)- | 5-(Pyridin-3-yl)-3-(1H-pyrrol-2-ylm...
- PKI166, Epidermal growth factor receptor erbB1 inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: P612856View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol
- SMILES
- OC(C=C1)=CC=C1C2=CC3=C(N2)N=CN=C3N[C@H](C)C4=CC=CC=C4
- InChIKey
- XRYJULCDUUATMC-CYBMUJFWSA-N
- InChI
- 1S/C20H18N4O/c1-13(14-5-3-2-4-6-14)23-19-17-11-18(24-20(17)22-12-21-19)15-7-9-16(25)10-8-15/h2-13,25H,1H3,(H2,21,22,23,24)/t13-/m1/s1
- Synonyms
- UNII-9RIE5HW38P | CGP75166 | CGP-75166 | 4-(4-((1-phenylethyl)amino)-7H-pyrrolo(2,3-d)pyrimidin-6-yl)-phenol, R- | 4-...
- PIM447, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinaseMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: P612836View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
- SMILES
- CC1CC(CC(C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F
- InChIKey
- VRQXRVAKPDCRCI-ZNMIVQPWSA-N
- InChI
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- Synonyms
- 5H7 | A903354 | GTPL9790 | yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide | SODIUM CYANIDE [MI] | US8592455, 70 | PI...
- PF-956980, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: P612759View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-pyrrolidin-1-ylmethanone
- SMILES
- CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)N4CCCC4
- InChIKey
- RONMOMUOZGIDET-HIFRSBDPSA-N
- InChI
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- Synonyms
- {(3r,4r)-4-Methyl-3-[methyl(7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)amino]piperidin-1-Yl}(Pyrrolidin-1-Yl)methanone | PF-0095...
- RGB-286638, Cyclin-dependent kinase 9 inhibitorCAS: 784210-88-4 Formula: C29H35N7O4 Molecular Weight: 545.63Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: R613171View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea
- SMILES
- COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6
- InChIKey
- XLSYZSRXVVCHLS-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- 1GAJ98SC2X | RGB-286638 free base | UNII-1GAJ98SC2X | EINECS 258-873-0 | AC-35303 | MFCD18633230 | 1-[3-[4-[[4-(2-met...
- cenisertib, Inhibitor of aurora kinase B;Inhibitor of kinase insert domain receptorCAS: 871357-89-0 PubChem CID: 11569967Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: C608472View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (1S,2S,3R,4R)-3-[[5-fluoro-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
- SMILES
- CC1=C(C=CC(=C1)NC2=NC=C(C(=N2)NC3C4CC(C3C(=O)N)C=C4)F)N5CCN(CC5)C
- InChIKey
- KSOVGRCOLZZTPF-QMKUDKLTSA-N
- InChI
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- Synonyms
- 5277GPA358 | Aurora kinase inhibitor as703569 | SY031985 | AC-28127 | GTPL9927 | enantiomer E1 [WO2005118544A2] | AKO...
- deuruxolitinib, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2CAS: 1513883-39-0 PubChem CID: 72704611Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: D609842View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (3R)-3-(2,2,3,3,4,4,5,5-octadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
- SMILES
- N#CC[C@H](C1C([2H])([2H])C(C(C1([2H])[2H])([2H])[2H])([2H])[2H])n1ncc(c1)c1ncnc2c1cc[nH]2
- InChIKey
- HFNKQEVNSGCOJV-FBXGHSCESA-N
- InChI
- 1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1/i1D2,2D2,3D2,4D2
- Synonyms
- 1H-PYRAZOLE-1-PROPANENITRILE, .BETA.-(CYCLOPENTYL-2,2,3,3,4,4,5,5-D8)-4-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)-, (.BETA.R)...
- Delgocitinib, Janus Kinase (JAK) inhibitorCAS: 1263774-59-9 EC Number: 849-957-3 PubChem CID: 50914062 Formula: C16H18N6O Molecular Weight: 310.35Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: D609797View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
- SMILES
- CC1CN(C12CCN(C2)C3=NC=NC4=C3C=CN4)C(=O)CC#N
- InChIKey
- LOWWYYZBZNSPDT-ZBEGNZNMSA-N
- InChI
- 1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1
- Synonyms
- 1,6-Diazaspiro(3.4)octane-1-propanenitrile, 3-methyl-beta-oxo-6-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-, (3S,4R)- | FT-076...
- EpitinibCAS: 1203902-67-3 Formula: C24H26N6O2 Molecular Weight: 430.50Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: E610164View ProductPricing & Pack Sizes
Technical Identifiers
- Synonyms
- 4-ethyl-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide | D96105 | 4-ETHYL-N-{4-[(3-E...
- golidocitinib, Tyrosine-protein kinase JAK1 inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: G610626View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide
- SMILES
- CC(C(=O)NC1=CC=CC2=C1NC=C2C3=NC(=NC=C3)NC4=CN(N=C4OC)C)N5CCN(CC5)C
- InChIKey
- CVCVOSPZEVINRM-MRXNPFEDSA-N
- InChI
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- Synonyms
- compound 21 [PMID: 32297743] | BDBM264212 | SCHEMBL18662606 | AZD4205 | AZD-4205 | 1-Piperazineacetamide, N-[3-[2-[(3...
- FosifidancitinibMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%◐ .Made to order · 8–12 wks Item #: F610384View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [5-[[2-(4-fluoro-3-methoxy-5-methylanilino)-5-methylpyrimidin-4-yl]amino]-2-oxo-1,3-benzoxazol-3-yl]methyl dihydrogen phosphate
- SMILES
- COc1cc(Nc2ncc(c(n2)Nc2ccc3c(c2)n(COP(=O)(O)O)c(=O)o3)C)cc(c1F)C
- InChIKey
- JTUBTEKGIDQZMZ-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- 2(3H)-Benzoxazolone, 5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methyl-4-pyrimidinyl)amino)-3-((phosphonooxy)...
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Frequently Asked Questions
What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].