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JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

1,726 products
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EGFR

852

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JAK

448

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Pim

83

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STAT

418

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Showing 517-528 of 1,726

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  1. iruplinalkib, Inhibitor of ALK receptor tyrosine kinase
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    iruplinalkib, Inhibitor of ALK receptor tyrosine kinase
    CAS: 1854943-32-0 PubChem CID: 118639856
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: I611153
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    IUPAC Name
    5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)phenyl]pyrimidine-2,4-diamine
    SMILES
    Clc1c(nc(nc1)Nc1c(cc(cc1)N1CCC2(CC1)CCN(CC2)C)OC)Nc1c(cccc1)P(=O)(C)C
    InChIKey
    ZPCCNHQDFZCULN-UHFFFAOYSA-N
    InChI
    1S/C29H38ClN6O2P/c1-35-15-11-29(12-16-35)13-17-36(18-14-29)21-9-10-23(25(19-21)38-2)33-28-31-20-22(30)27(34-28)32-24-7-5-6-8-26(24)39(3,4)37/h5-10,19-show more
    Synonyms
    GLXC-26941 | Z5F65W1YAZ | GTPL11877 | 2,4-Pyrimidinediamine, 5-chloro-N4-(2-(dimethylphosphinyl)phenyl)-N2-(2-methoxy...
  2. ivarmacitinib, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2
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    ivarmacitinib, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2
    CAS: 1445987-21-2 PubChem CID: 71622431 Formula: C18H22N8O2S Molecular Weight: 414.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: I611211
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    IUPAC Name
    (3aS,6aR)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboshow more
    SMILES
    CN(C1CC2CN(CC2C1)C(=O)NC3=NC(=NS3)OC)C4=NC=NC5=C4C=CN5
    InChIKey
    DNBCBAXDWNDRNO-FOSCPWQOSA-N
    InChI
    1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,show more
    Synonyms
    IVARMACITINIB [INN] | AKOS040759719 | SCHEMBL15077710 | SHR0302 | SHR-0302 | Cyclopenta(c)pyrrole-2(1H)-carboxamide, ...
  3. izencitinib, Janus Kinase (JAK) inhibitor
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    izencitinib, Janus Kinase (JAK) inhibitor
    CAS: 2051918-33-1 Formula: C22H26N8 Molecular Weight: 402.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: I611212
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    IUPAC Name
    3-[(1R,5S)-3-[[7-[(5-methyl-1H-pyrazol-3-yl)amino]-1,6-naphthyridin-5-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl]propanenitrile
    SMILES
    N#CCCN1[C@@H]2CC[C@H]1CC(C2)Nc1nc(Nc2n[nH]c(c2)C)cc2c1cccn2
    InChIKey
    DADAEARVGOQWHV-ALOPSCKCSA-N
    InChI
    1S/C22H26N8/c1-14-10-21(29-28-14)26-20-13-19-18(4-2-8-24-19)22(27-20)25-15-11-16-5-6-17(12-15)30(16)9-3-7-23/h2,4,8,10,13,15-17H,3,5-6,9,11-12H2,1H3,(show more
    Synonyms
    TD1473 | TD-1473 | Izencitinib [USAN:INN] | Izencitinib | 2ZT81PV5UM | Izencitinib [USAN] | MS-26864 | GLXC-26798 | 3...
  4. itacnosertib, Inhibitor of activin A receptor type 1;Inhibitor of Janus kinase 2
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    itacnosertib, Inhibitor of activin A receptor type 1;Inhibitor of Janus kinase 2
    CAS: 1628870-27-8 PubChem CID: 86290265
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: I611201
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    IUPAC Name
    2-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-N-(2-pyridin-2-ylpyridin-3-yl)pyrimidine-2,4-diamine
    SMILES
    COc1cc(ccc1N1CCN(CC1)C)Nc1nccc(n1)Nc1cccnc1c1ccccn1
    InChIKey
    XSQKEVGTZSBVBR-UHFFFAOYSA-N
    InChI
    1S/C26H28N8O/c1-33-14-16-34(17-15-33)22-9-8-19(18-23(22)35-2)30-26-29-13-10-24(32-26)31-21-7-5-12-28-25(21)20-6-3-4-11-27-20/h3-13,18H,14-17H2,1-2H3,(show more
    Synonyms
    UNII-22Z53X5LHF | 22Z53X5LHF | example 11 [WO2014151871A9] | Itacnosertib | GTPL10632 | SCHEMBL16129103 | Itacnoserti...
  5. oclacitinib, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2
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    oclacitinib, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2
    CAS: 1208319-26-9 EC Number: 950-980-7 PubChem CID: 44631938 Formula: C15H23N5O2S Molecular Weight: 337.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ● In Stock — US warehouse, ships to EU* Item #: O612457
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    IUPAC Name
    N-methyl-1-[4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]methanesulfonamide
    SMILES
    CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3
    InChIKey
    HJWLJNBZVZDLAQ-UHFFFAOYSA-N
    InChI
    1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)
    Synonyms
    D10141 | N-Methyl-1-(trans-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide | OCLACITINI...
  6. nezulcitinib, Janus Kinase (JAK) inhibitor
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    nezulcitinib, Janus Kinase (JAK) inhibitor
    CAS: 2412496-23-0 Formula: C30H37N7O2 Molecular Weight: 527.7
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: N612276
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    IUPAC Name
    [3-(dimethylamino)azetidin-1-yl]-[(6S)-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-indazol-3-yl]-5-propan-2-yl-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-6-yl]methshow more
    SMILES
    CCc1cc(O)ccc1c1ccc2c(c1)[nH]nc2c1nc2c([nH]1)C[C@H](N(C2)C(C)C)C(=O)N1CC(C1)N(C)C
    InChIKey
    VQIIUJSNIKEMCK-MHZLTWQESA-N
    InChI
    1S/C30H37N7O2/c1-6-18-11-21(38)8-10-22(18)19-7-9-23-24(12-19)33-34-28(23)29-31-25-13-27(37(17(2)3)16-26(25)32-29)30(39)36-14-20(15-36)35(4)5/h7-12,17,show more
    Synonyms
    TD-0903 | WHO 11732 | HY-132849 | example 1 [WO2020051105A1] | SCHEMBL21772319 | (3-(DIMETHYLAMINO)AZETIDIN-1-YL)((6S...
  7. povorcitinib, Inhibitor of Janus kinase 1
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    povorcitinib, Inhibitor of Janus kinase 1
    CAS: 1637677-22-5 Formula: C23H22F5N7O Molecular Weight: 507.46
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: P612900
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    Technical Identifiers
    IUPAC Name
    4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide
    SMILES
    C(#N)CC1(CN(C1)c1cc(c(C(=O)N[C@H](C(F)(F)F)C)cc1F)F)n1ncc(c1)c1c(n[nH]c1C)C
    InChIKey
    MSGYSFWCPOBHEV-AWEZNQCLSA-N
    InChI
    1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3Hshow more
    Synonyms
    AKOS040756953 | UNII-N0JWC7RO00 | (S)-4-(3-(Cyanomethyl)-3-(3',5'-dimethyl-1H,1'H-(4,4'-bipyrazol)-1-yl)azetidin-1-yl...
  8. pumecitinib
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    pumecitinib
    CAS: 2401057-12-1 PubChem CID: 141761076
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: P613017
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    IUPAC Name
    2-[3-[3-amino-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-1-propan-2-ylsulfonylazetidin-3-yl]acetonitrile
    SMILES
    CC(C)S(=O)(=O)N1CC(C1)(CC#N)n1cc(c(n1)N)c1c2cc[nH]c2ncn1
    InChIKey
    OUXYFMCMGWQWQF-UHFFFAOYSA-N
    InChI
    1S/C17H20N8O2S/c1-11(2)28(26,27)24-8-17(9-24,4-5-18)25-7-13(15(19)23-25)14-12-3-6-20-16(12)22-10-21-14/h3,6-7,10-11H,4,8-9H2,1-2H3,(H2,19,23)(H,20,21,show more
    Synonyms
    MS-26800 | pumecitinib [INN] | Pumecitinib | 2-[3-[3-amino-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-1-propan-...
  9. pyrotinib, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2
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    pyrotinib, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2
    CAS: 1269662-73-8 PubChem CID: 51039030 Formula: C32H31ClN6O3 Molecular Weight: 583.08
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P613029
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    IUPAC Name
    (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide
    SMILES
    CCOc1cc2ncc(c(c2cc1NC(=O)/C=C/[C@H]1CCCN1C)Nc1ccc(c(c1)Cl)OCc1ccccn1)C#N
    InChIKey
    SADXACCFNXBCFY-IYNHSRRRSA-N
    InChI
    1S/C32H31ClN6O3/c1-3-41-30-17-27-25(16-28(30)38-31(40)12-10-24-8-6-14-39(24)2)32(21(18-34)19-36-27)37-22-9-11-29(26(33)15-22)42-20-23-7-4-5-13-35-23/hshow more
    Synonyms
    SHR1258 | SHR-1258 | SCHEMBL9948753 | compound 12 [PMID: 28115222] | GTPL9662 | WZB08997 | (R,E)-N-(4-((3-chloro-4-(p...
  10. sacibertinib
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    sacibertinib
    CAS: 1351941-69-9 PubChem CID: 89496273
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: S613392
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    IUPAC Name
    (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-[(3S)-oxolan-3-yl]oxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
    SMILES
    [C@@H]1(CCOC1)Oc1cc2ncc(C#N)c(Nc3ccc(OCc4ncccc4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C
    InChIKey
    ZGYIXVSQHOKQRZ-COIATFDQSA-N
    InChI
    1S/C32H31ClN6O4/c1-39(2)12-5-7-31(40)38-28-15-25-27(16-30(28)43-24-10-13-41-20-24)36-18-21(17-34)32(25)37-22-8-9-29(26(33)14-22)42-19-23-6-3-4-11-35-2show more
    Synonyms
    (2E)-N-[(1(3)S)-5(3)-chloro-3(3)-cyano-2,6-dioxa-4-aza-3(7,4)-quinolina-8(2)-pyridina-1(3)-oxolana-5(1,4)-benzenaocta...
  11. selatinib, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2
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    selatinib, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2
    CAS: 1275595-86-2 PubChem CID: 51348455
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: S613520
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    IUPAC Name
    N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfinylethylamino)methyl]furan-2-yl]quinazolin-4-amine
    SMILES
    CS(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
    InChIKey
    OAMVGUFHZPRXOM-UHFFFAOYSA-N
    InChI
    1S/C29H26ClFN4O3S/c1-39(36)12-11-32-16-23-7-10-27(38-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)37-17-19-3-2-4-21(31)13-19/h2-10,13show more
    Synonyms
    HY-116437 | Z2235824128 | GTPL9919 | UNII-6TLR8U8O3C | AT24534 | Selatinib | 4-Quinazolinamine, N-(3-chloro-4-((3-flu...
  12. simotinib, Epidermal growth factor receptor erbB1 inhibitor
    Wish List Compare
    simotinib, Epidermal growth factor receptor erbB1 inhibitor
    CAS: 944258-89-3 PubChem CID: 16735117 Formula: C25H26ClFN4O4 Molecular Weight: 500.9
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: S613586
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    Technical Identifiers
    IUPAC Name
    N-(3-chloro-4-fluorophenyl)-6-[2-(5,8-dioxa-10-azadispiro[2.0.44.33]undecan-10-yl)ethoxy]-7-methoxyquinazolin-4-amine
    SMILES
    COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCN4CC5(CC5)C6(C4)OCCO6
    InChIKey
    OXWUWXCJDBRCCG-UHFFFAOYSA-N
    InChI
    1S/C25H26ClFN4O4/c1-32-21-12-20-17(23(29-15-28-20)30-16-2-3-19(27)18(26)10-16)11-22(21)33-7-6-31-13-24(4-5-24)25(14-31)34-8-9-35-25/h2-3,10-12,15H,4-9show more
    Synonyms
    SIM-6802 | 4-QUINAZOLINAMINE, N-(3-CHLORO-4-FLUOROPHENYL)-6-(2-(5,8-DIOXA-10-AZADISPIRO(2.0.4.3)UNDEC-10-YL)ETHOXY)-7...
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].
JAK/STAT signaling pages help researchers compare compounds relevant to cytokine signaling, transcriptional response, immune biology, and proliferative disease studies. Key evaluation points often include pathway node, isoform selectivity, upstream receptor context, cellular potency, biomarker response, and disease relevance. This category is useful when experiments need to connect receptor-level signaling with transcriptional outcomes across related pathway nodes. It supports both mechanism studies and discovery-stage compound selection.
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