Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.
JAK/STAT Signaling
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- ruserontinib, Tyrosine-protein kinase ABL inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: R613335View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-N-[4-(4-methylpiperazin-1-yl)phenyl]-9-propan-2-yl-8-N-pyridin-3-ylpurine-2,8-diamine
- SMILES
- CN1CCN(CC1)c1ccc(cc1)Nc1ncc2nc(n(c2n1)C(C)C)Nc1cnccc1
- InChIKey
- WSOHOUHPUOAXIN-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- 9-(1-Methylethyl)-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-3-pyridinyl-9H-purine-2,8-diamine | 9H-Purine-2,8-diamine,...
- sunvozertinib, Inhibitor of Bruton tyrosine kinase;Inhibitor of epidermal growth factor receptorCAS: 2370013-12-8 PubChem CID: 139377809Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: S613757View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- show more
- SMILES
- Clc1c(cc(c(Nc2nc(ncc2)Nc2c(cc(c(c2)NC(=O)C=C)N2C[C@@H](CC2)N(C)C)OC)c1)C(C)(C)O)F
- InChIKey
- BTMKEDDEMKKSEF-QGZVFWFLSA-N
- InChI
- show more
- Synonyms
- EX-A6612 | ASYM-122507 | HY-132842 | sunvozertinib | GLXC-25829 | DZ00000586 | GTPL11672 | Example 52 [WO2019149164A1...
- uzansertib, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinaseCAS: 1620012-39-6 PubChem CID: 129606875Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: U614695View ProductPricing & Pack Sizes
Technical Identifiers
- SMILES
- C[C@@H]1CN(C[C@@H]([C@H]1O)N)c1c(cnc2c1CC[C@@H]2O)NC(=O)c1ccc(c(n1)c1c(F)cccc1F)F
- InChIKey
- PTORCEYGCGXHDH-SGQXWQAPSA-N
- InChI
- show more
- Synonyms
- INCB-053914 | INCB053914
- Amivantamab (anti-c-Met), Antibody of epidermal growth factor receptor;Antibody of MET proto-oncogene; receptor tyrosine kinaseCAS: 2171511-58-1Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥95%(SDS-PAGE&SEC-HPLC) See COA● In Stock — US warehouse, ships to EU* Item #: Ab175451View ProductPricing & Pack Sizes
Technical Identifiers
- Associated targets
- EGFR MET
- Short Overview
- Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
- Reactive species
- Human, Mouse
- Isotype
- Human IgG1
- Host species
- Human
- Conjugation
- Unconjugated
- Synonyms
- AUTS9 antibody | c met antibody | D249 antibody | Hepatocyte growth factor receptor antibody | HGF antibody | HGF rec...
- Trastuzumab emtansine (anti-ERBB2), INHIBITOR of Receptor protein-tyrosine kinase erbB-2 inhibitorCAS: 1018448-65-1 PubChem CID: 163341910Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥90%(SDS-PAGE&SEC-HPLC) See COA◐ .US Made to order · 2–4 wks Item #: Ab175686View ProductPricing & Pack Sizes
Technical Identifiers
- Associated targets
- ERBB2
- Short Overview
- Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Conjugated (SMCC-DM1)
- Reactive species
- Human
- Isotype
- Human IgG1
- Host species
- Human
- Conjugation
- SMCC-DM1
- SMILES
- show more
- Synonyms
- Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | C er...
- BLU945, Inhibitor of epidermal growth factor receptorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: B608108View ProductPricing & Pack Sizes
Technical Identifiers
- Synonyms
- BLU 945 | BLU945 | BLU-945 | AKOS040759965 | UNII-PA4PTH5HL9 | 2660250-10-0 | 3-Isoquinolinamine, N-(2-((3S,4R)-3-flu...
- GDC-0214, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: G610530View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- show more
- SMILES
- CN(CCC#N)C1CCN(CC1)C(=O)CN2C=C(C(=N2)C3=C(C=CC(=C3)Cl)OC(F)F)NC(=O)C4=C5N=CC=CN5N=C4
- InChIKey
- ITNFPSJJBYFVEA-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- GDC0214;iJak-381;RG-6151;RG6151
- HJC0152CAS: 1420290-88-5 PubChem CID: 71527596Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: H610846View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
- SMILES
- NCCOc1c(cc(Cl)cc1)C(=O)Nc1c(Cl)cc(cc1)[N+](=O)[O-]
- InChIKey
- DIMJVBOEXNWPOG-UHFFFAOYSA-N
- InChI
- 1S/C15H13Cl2N3O4/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17/h1-4,7-8H,5-6,18H2,(H,19,21)
- Synonyms
- compound 11;compound 11 [WO2014113467A1];HJC-0152;HJC-1-52
- LLL12, Inhibitor of signal transducer and activator of transcription 3CAS: 1260247-42-4 Formula: C14H9NO5S Molecular Weight: 303.29Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%◐ .Made to order · 8–12 wks Item #: L611558View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-hydroxy-9,10-dioxoanthracene-1-sulfonamide
- SMILES
- C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N
- InChIKey
- CQBHSRLUQDYPBU-UHFFFAOYSA-N
- InChI
- 1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20)
- Synonyms
- 9,10-Dihydro-5-hydroxy-9,10-dioxo-1-anthracenesulfonamide | NCGC00345811-01 | 5-hydroxy-9,10-dioxoanthracene-1-sulfon...
- ilunocitinibCAS: 1187594-14-4 PubChem CID: 44231134Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: I611035View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-[1-cyclopropylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
- SMILES
- C1CC1S(=O)(=O)N1CC(C1)(CC#N)n1cc(cn1)c1c2cc[nH]c2ncn1
- InChIKey
- RVOUEXFKIYNODQ-UHFFFAOYSA-N
- InChI
- 1S/C17H17N7O2S/c18-5-4-17(9-23(10-17)27(25,26)13-1-2-13)24-8-12(7-22-24)15-14-3-6-19-16(14)21-11-20-15/h3,6-8,11,13H,1-2,4,9-10H2,(H,19,20,21)
- Synonyms
- WHO 11894 | 1187594-14-4 | UNII-N3TB5AH8B9 | ILUNOCITINIB [INN] | MS-26294 | 3-Azetidineacetonitrile, 1-(cyclopropyls...
- ifidancitinibCAS: 1236667-40-5 PubChem CID: 46851625Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: I610943View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[[2-(4-fluoro-3-methoxy-5-methylanilino)-5-methylpyrimidin-4-yl]amino]-3H-1,3-benzoxazol-2-one
- SMILES
- COc1cc(Nc2ncc(c(n2)Nc2ccc3c(c2)[nH]c(=O)o3)C)cc(c1F)C
- InChIKey
- OYFMQDVLFYKOPZ-UHFFFAOYSA-N
- InChI
- 1S/C20H18FN5O3/c1-10-6-13(8-16(28-3)17(10)21)24-19-22-9-11(2)18(26-19)23-12-4-5-15-14(7-12)25-20(27)29-15/h4-9H,1-3H3,(H,25,27)(H2,22,23,24,26)
- Synonyms
- 5-((2-(4-Fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-yl)amino)benzo(d)oxazol-2(3H)-one | ifidancitinib ...
- mavelertinib, Epidermal growth factor receptor erbB1 inhibitorCAS: 1776112-90-3 EC Number: 815-270-2 PubChem CID: 91668194 Formula: C18H22FN9O2 Molecular Weight: 415.42Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: M611747View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-methylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
- SMILES
- CN1C=C(C(=N1)OC)NC2=C3C(=NC(=N2)N4CC(C(C4)F)NC(=O)C=C)N(C=N3)C
- InChIKey
- JYIUNVOCEFIUIU-GHMZBOCLSA-N
- InChI
- show more
- Synonyms
- GTPL9765 | PF6747775 | AC-33593 | (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinic acid | MAVELERTINIB [INN] | YXX2180047 ...
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Pack Size Options Multiple packaging sizes with pricing access from listing
R&D Use Only Products supplied for research and development use
Frequently Asked Questions
What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].