Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.
JAK/STAT Signaling
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- tesevatinib, Receptor protein-tyrosine kinase erbB-2 inhibitorSolid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%◐ .Made to order · 8–12 wks Item #: T614389View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 7-[[(3aS,6aR)-2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]methoxy]-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine
- SMILES
- CN1CC2CC(CC2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC
- InChIKey
- HVXKQKFEHMGHSL-GOOCMWNKSA-N
- InChI
- show more
- Synonyms
- 7-[[(3aS,6aR)-2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]methoxy]-N-(3,4-dichloro-2-fluorophenyl)-6...
- Depatuxizumab mafodotin (anti-EGFR), BINDING AGENT of Epidermal growth factor receptor erbB1 binding agentCAS: 1585973-65-4Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. PBS Only ? PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers. ≥95%(SDS-PAGE&SEC-HPLC) See COA● In Stock — US warehouse, ships to EU* Item #: Ab175508View ProductPricing & Pack Sizes
Technical Identifiers
- Associated targets
- EGFR
- Short Overview
- Purity>95% ( SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (Mc-MMAF)
- Reactive species
- Human
- Isotype
- Human IgG1
- Host species
- Human
- Conjugation
- Mc-MMAF
- Synonyms
- Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody ...
- Nimotuzumab (anti-EGFR), INHIBITOR of Epidermal growth factor receptor erbB1 inhibitorCAS: 780758-10-3Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥95%(SDS-PAGE&SEC-HPLC) See COA● In Stock — US warehouse, ships to EU* Item #: Ab175612View ProductPricing & Pack Sizes
Technical Identifiers
- Associated targets
- EGFR
- Short Overview
- Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
- Reactive species
- Cynomolgus monkey, Human
- Isotype
- Human IgG1
- Host species
- Human
- Conjugation
- Unconjugated
- Synonyms
- Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody ...
- Seribantumab (anti-ERBB3), Antibody of erb-b2 receptor tyrosine kinase 3CAS: 1334296-12-6Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥95%(SDS-PAGE&SEC-HPLC) See COA● In Stock — US warehouse, ships to EU* Item #: Ab175653View ProductPricing & Pack Sizes
Technical Identifiers
- Associated targets
- ERBB3
- Short Overview
- Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
- Reactive species
- Human, Mouse
- Isotype
- Human IgG2
- Host species
- Human
- Conjugation
- Unconjugated
- Synonyms
- c erbB 3 antibody | c erbB3 antibody | Erb b2 receptor tyrosine kinase 3 antibody | ErbB 3 antibody | ERBB3 antibody ...
- (11R)-16-bromo-5,11,26-trimethyl-7-oxa-4,5,13,20,22,27-hexaazapentacyclo[22.3.1.0²,⁶.0¹³,²¹.0¹⁴,¹⁹]octacosa-1(28),2(6),3,14,16,18,21,24,26-nonaen-23-one◐ .Made to order · 8–12 wks Item #: B638046View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- show more
- SMILES
- CC1CCCOC2=C(C=NN2C)C3=NC(=CC(=C3)C(=O)NC4=NC5=C(N4C1)C=C(C=C5)Br)C
- InChIKey
- UPMBIKXABDDVHH-CQSZACIVSA-N
- InChI
- show more
- Synonyms
- EGFR-IN-15 | 2573869-16-4 | AKOS040757870 | HY-138746 | F89541
- 5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine◐ .Made to order · 8–12 wks Item #: P627862View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
- SMILES
- C1CS(=O)(=O)CCN1CC2=CC=C(C=C2)C3=CC=CC4=NC(=NN43)N
- InChIKey
- BYWJAVQGRJEEHH-UHFFFAOYSA-N
- InChI
- 1S/C17H19N5O2S/c18-17-19-16-3-1-2-15(22(16)20-17)14-6-4-13(5-7-14)12-21-8-10-25(23,24)11-9-21/h1-7H,8-12H2,(H2,18,20)
- Synonyms
- 5-[4-(1,1-Dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine | 5-{-4-[(1,1-dioxidothiomor...
- Protosappanin A◐ .Made to order · 8–12 wks Item #: P646214View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5,14,15-trihydroxy-8-oxatricyclo[10.4.0.02,7]hexadeca-1(16),2(7),3,5,12,14-hexaen-10-one
- SMILES
- C1C(=O)COC2=C(C=CC(=C2)O)C3=CC(=C(C=C31)O)O
- InChIKey
- MUKYVRVYBBYJSI-UHFFFAOYSA-N
- InChI
- 1S/C15H12O5/c16-9-1-2-11-12-6-14(19)13(18)4-8(12)3-10(17)7-20-15(11)5-9/h1-2,4-6,16,18-19H,3,7H2
- Synonyms
- HY-113573 | CHEBI:69202 | MS-23852 | Q27137541 | 6H-Dibenz(b,d)oxocin-7(8H)-one, 3,10,11-trihydroxy- | 3,10,11-trihyd...
- M-110◐ .Made to order · 8–12 wks Item #: M646193View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[(E)-1-(4-chloro-2-hydroxyphenyl)propylideneamino]-2-(3-morpholin-4-ylpropylamino)pyridine-4-carboxamide
- SMILES
- CCC(=NNC(=O)C1=CC(=NC=C1)NCCCN2CCOCC2)C3=C(C=C(C=C3)Cl)O
- InChIKey
- FXXCNYVQIONABS-LGUFXXKBSA-N
- InChI
- show more
- TyK2-IN-2◐ .Made to order · 8–12 wks Item #: T646306View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6-(3,5-dimethylanilino)-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide
- SMILES
- CC1=CC(=CC(=C1)NC2=NN3C(=CN=C3C(=C2)NC)C(=O)N)C
- InChIKey
- SNVFFECYFQEWTL-UHFFFAOYSA-N
- InChI
- 1S/C16H18N6O/c1-9-4-10(2)6-11(5-9)20-14-7-12(18-3)16-19-8-13(15(17)23)22(16)21-14/h4-8,18H,1-3H3,(H2,17,23)(H,20,21)
- JAK-IN-25CAS: 2127110-22-7 Formula: C19H17N5O4 Molecular Weight: 379.37◐ .Made to order · 8–12 wks Item #: J646128View ProductPricing & Pack Sizes
Technical Identifiers
- TX1-85-1CAS: 1603845-32-4 Formula: C32H36N8O3 Molecular Weight: 580.68Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%◐ .Made to order · 8–12 wks Item #: T646130View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[5-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]prop-2-enamide
- SMILES
- CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)OC6=CC=CC=C6)NC(=O)C=C)N
- InChIKey
- FYICDSWKKFSYOM-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- N-(5-(1-(4-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-phenoxyphenyl)acrylamide
- 8-Epixanthatin◐ .Made to order · 8–12 wks Item #: E646241View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (3aR,7S,8aR)-7-methyl-3-methylidene-6-[(E)-3-oxobut-1-enyl]-4,7,8,8a-tetrahydro-3aH-cyclohepta[b]furan-2-one
- SMILES
- CC1CC2C(CC=C1C=CC(=O)C)C(=C)C(=O)O2
- InChIKey
- RBRPTFMVULVGIC-MDKNCZOUSA-N
- InChI
- 1S/C15H18O3/c1-9-8-14-13(11(3)15(17)18-14)7-6-12(9)5-4-10(2)16/h4-6,9,13-14H,3,7-8H2,1-2H3/b5-4+/t9-,13+,14+/m0/s1
- Synonyms
- HY-137974 | Q27270227 | 2H-Cyclohepta(b)furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxo-1-butenyl)...
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Technical Details Quality & specification info on every product page
Pack Size Options Multiple packaging sizes with pricing access from listing
R&D Use Only Products supplied for research and development use
Frequently Asked Questions
What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].