EGFR
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- EGFR inhibitor, Inhibitor of epidermal growth factor receptorCAS: 879127-07-8 Formula: C21H18F3N5O Molecular Weight: 413.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: E337818View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
- SMILES
- C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F
- InChIKey
- YOHYSYJDKVYCJI-UHFFFAOYSA-N
- InChI
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- Synonyms
- K00598a | AKOS000120473 | EGFR inhibitor(YUN27078) | EGFR Inhibitor [879127-07-8] | EGFR Inhibitor - CAS 879127-07-8 ...
- EAI045, Allosteric modulator of epidermal growth factor receptorCAS: 1942114-09-1 Formula: C19H14FN3O3S Molecular Weight: 383.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: E422370View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
- SMILES
- C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4
- InChIKey
- YTUFHOKUFOQRDF-UHFFFAOYSA-N
- InChI
- 1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)
- Synonyms
- 2H-Isoindole-2-acetamide,α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-
- EBE-A22CAS: 229476-53-3 Formula: C17H16BrN3O2 Molecular Weight: 374.2310mM in DMSO● In Stock — US warehouse, ships to EU* Item #: E422730View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine
- SMILES
- CN(C1=CC(=CC=C1)Br)C2=NC=NC3=CC(=C(C=C32)OC)OC
- InChIKey
- IPWGDOZPSOZFOD-UHFFFAOYSA-N
- InChI
- 1S/C17H16BrN3O2/c1-21(12-6-4-5-11(18)7-12)17-13-8-15(22-2)16(23-3)9-14(13)19-10-20-17/h4-10H,1-3H3
- Synonyms
- EBE-A 22;EBE A22; EBEA22 | MS-26039 | N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine | s6530 | AKOS030526...
- EGFR-IN-5CAS: 2225887-26-1 Formula: C31H38FN9O Molecular Weight: 571.69◐ .Made to order · 8–12 wks Item #: E413697View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [1-[6-[[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]amino]-2-(4-fluoroanilino)pyrido[3,4-d]pyrimidin-4-yl]piperidin-4-yl]methanol
- SMILES
- CN(C)C1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C(=C3)C(=NC(=N4)NC5=CC=C(C=C5)F)N6CCC(CC6)CO
- InChIKey
- DXOUQSZKEPSXBC-UHFFFAOYSA-N
- InChI
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- EGFR-IN-7CAS: 2267329-76-8 Formula: C32H41BrN9O2P Molecular Weight: 694.60● In Stock — US warehouse, ships to EU* Item #: E401064View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-bromo-4-N-(5-dimethylphosphorylquinoxalin-6-yl)-2-N-[2-methoxy-5-methyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine
- SMILES
- CC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C)OC)NC4=NC=C(C(=N4)NC5=C(C6=NC=CN=C6C=C5)P(=O)(C)C)Br
- InChIKey
- ZYSKXRAGBGLELB-UHFFFAOYSA-N
- InChI
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- Synonyms
- TQB3804
- EGFR/ErbB-2/ErbB-4 inhibitor-2 , Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2CAS: 179248-61-4 Formula: C23H21N3O3 Molecular Weight: 387.43Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: E337825View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine
- SMILES
- COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
- InChIKey
- DNOKYISWMVFYFA-UHFFFAOYSA-N
- InChI
- 1S/C23H21N3O3/c1-27-21-12-19-20(13-22(21)28-2)24-15-25-23(19)26-17-8-10-18(11-9-17)29-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,24,25,26)
- Synonyms
- 4557W | 4-Quinazolinamine, 6,7-dimethoxy-N-[4-(phenylmethoxy)phenyl]- | EGFR/ErbB2 Inhibitor | EGFR/ErbB-2 Inhibitor ...
- EGFR inhibitor, Inhibitor of epidermal growth factor receptorCAS: 879127-07-8 Formula: C21H18F3N5O Molecular Weight: 413.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: E426643View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
- SMILES
- C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F
- InChIKey
- YOHYSYJDKVYCJI-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- K00598a | AKOS000120473 | EGFR inhibitor(YUN27078) | EGFR Inhibitor [879127-07-8] | EGFR Inhibitor - CAS 879127-07-8 ...
- Epertinib hydrochloride◐ .Made to order · 8–12 wks Item #: E413670View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[(Z)-N-[[(3R)-morpholin-3-yl]methoxy]-C-prop-1-ynylcarbonimidoyl]quinazolin-4-amine;hydrochloride
- SMILES
- CC#CC(=NOCC1COCCN1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl
- InChIKey
- NVWJPQQXBPWOOA-PLXRJBJVSA-N
- InChI
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- Synonyms
- Epertinib HCl | S-222611 hydrochloride | S-222611 HCl
- Erlotinib-d6 HClCAS: 1189953-78-3 Formula: C22H18D6ClN3O4 Molecular Weight: 399.48 + 36.46● In Stock — US warehouse, ships to EU* Item #: E381498View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-ethynylphenyl)-6,7-bis[2-(trideuteriomethoxy)ethoxy]quinazolin-4-amine;hydrochloride
- SMILES
- COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
- InChIKey
- GTTBEUCJPZQMDZ-HVTBMTIBSA-N
- InChI
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- Synonyms
- Tarceva-d3 | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride
- Gefitinib hydrochloride saltCAS: 184475-55-6 Formula: C22H25Cl2FN4O3 Molecular Weight: 483.372mM in DMSO● In Stock — US warehouse, ships to EU* Item #: G422258View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;hydrochloride
- SMILES
- COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl
- InChIKey
- QUINXWLATMJDQF-UHFFFAOYSA-N
- InChI
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- Synonyms
- ZD1839 hydrochloride | ZD-1839 hydrochloride | 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy...
- Gefitinib hydrochloride saltCAS: 184475-55-6 Formula: C22H25Cl2FN4O3 Molecular Weight: 483.37● In Stock — US warehouse, ships to EU* Item #: G337638View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;hydrochloride
- SMILES
- COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl
- InChIKey
- QUINXWLATMJDQF-UHFFFAOYSA-N
- InChI
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- Synonyms
- ZD1839 hydrochloride | ZD-1839 hydrochloride | 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy...
- HG-14-10-04CAS: 1356962-34-9 Formula: C29H34ClN7O Molecular Weight: 532.0810mM in DMSO● In Stock — US warehouse, ships to EU* Item #: H421355View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine
- SMILES
- CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)C5=CNC6=CC=CC=C65)Cl)OC
- InChIKey
- HRYNCLKDKCPYBF-UHFFFAOYSA-N
- InChI
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- Synonyms
- A906951 | AC-36124 | HY-15801 | HG141004 | HG-14-10-04 | 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-pip...
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
How is the EGFR listing put together?
It draws on reported EGFR annotations within JAK/STAT Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an EGFR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the EGFR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for EGFR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For EGFR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the EGFR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of EGFR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.