EGFR
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- HG-14-10-04CAS: 1356962-34-9 Formula: C29H34ClN7O Molecular Weight: 532.08● In Stock — US warehouse, ships to EU* Item #: H413495View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine
- SMILES
- CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)C5=CNC6=CC=CC=C65)Cl)OC
- InChIKey
- HRYNCLKDKCPYBF-UHFFFAOYSA-N
- InChI
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- Synonyms
- A906951 | AC-36124 | HY-15801 | HG141004 | HG-14-10-04 | 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-pip...
- HS-10296CAS: 1899921-05-1 Formula: C30H35N7O2 Molecular Weight: 525.64Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: H422329View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
- SMILES
- CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC
- InChIKey
- DOEOECWDNSEFDN-UHFFFAOYSA-N
- InChI
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- Synonyms
- 1899921-05-1 | Egfr T790M inhibitor HS-10296 | HS10296 | HS-10296 | N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]...
- JBJ-03-142-02CAS: 2068806-31-3 Formula: C25H22FN7O3 Molecular Weight: 487.5◐ .Made to order · 8–12 wks Item #: J286542View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (4-fluorophenyl)methyl N-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-N-[3-(prop-2-enoylamino)phenyl]carbamate
- SMILES
- CN1C=C(C=N1)NC2=NC=CC(=N2)N(C3=CC=CC(=C3)NC(=O)C=C)C(=O)OCC4=CC=C(C=C4)F
- InChIKey
- IFRXGTCPIGRGHP-UHFFFAOYSA-N
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- Synonyms
- (4-Fluorophenyl)methylN-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]c...
- JCN037CAS: 2305154-31-6 Formula: C16H11BrFN3O2 Molecular Weight: 376.18● In Stock — US warehouse, ships to EU* Item #: J412606View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
- SMILES
- C1COC2=C(O1)C=C3C(=C2)N=CN=C3NC4=C(C(=CC=C4)Br)F
- InChIKey
- MTLUFWWVOINWEL-UHFFFAOYSA-N
- InChI
- 1S/C16H11BrFN3O2/c17-10-2-1-3-11(15(10)18)21-16-9-6-13-14(23-5-4-22-13)7-12(9)19-8-20-16/h1-3,6-8H,4-5H2,(H,19,20,21)
- Synonyms
- JGK037 | N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
- JND3229CAS: 2260886-64-2 Formula: C33H41ClN8O2 Molecular Weight: 617.18Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: J413666View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[4-[3-(2-chlorophenyl)-7-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]cyclohexyl]propanamide
- SMILES
- CCC(=O)NC1CCC(CC1)N2C3=NC(=NC=C3CN(C2=O)C4=CC=CC=C4Cl)NC5=CC(=C(C=C5)N6CCN(CC6)C)C
- InChIKey
- WVLWGBZNXIVAKC-UHFFFAOYSA-N
- InChI
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- Synonyms
- N-(trans-4-(3-(2-Chlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]p...
- Lazertinib, Epidermal growth factor receptor erbB1 inhibitorSolid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: L414136View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
- SMILES
- CN(C)CC1=CN(N=C1C2=CC=CC=C2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC
- InChIKey
- RRMJMHOQSALEJJ-UHFFFAOYSA-N
- InChI
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- Synonyms
- CCG-270023 | Leclaza | RRMJMHOQSALEJJ-UHFFFAOYSA-N | (E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,...
- Lapatinib ditosylate monohydrate, Epidermal growth factor receptor erbB1 inhibitorCAS: 388082-78-8 EC Number: 642-915-3 PubChem CID: 11557040 Formula: C43H44ClFN4O11S3 Molecular Weight: 943.4910mM in DMSO● In Stock — US warehouse, ships to EU* Item #: L423794View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O
- InChIKey
- XNRVGTHNYCNCFF-UHFFFAOYSA-N
- InChI
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- Synonyms
- 388082-78-8|Lapatinib ditosylate hydrate|Tykerb|Lapatinib Ditosylate|LAPATINIB DITOSYLATE MONOHYDRATE|Tyverb|Tycerb|l...
- Lazertinib, Epidermal growth factor receptor erbB1 inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 2mM in DMSO● In Stock — US warehouse, ships to EU* Item #: L422330View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
- SMILES
- CN(C)CC1=CN(N=C1C2=CC=CC=C2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC
- InChIKey
- RRMJMHOQSALEJJ-UHFFFAOYSA-N
- InChI
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- Synonyms
- CCG-270023 | Leclaza | RRMJMHOQSALEJJ-UHFFFAOYSA-N | (E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,...
- Lifirafenib (BGB-283), Serine/threonine-protein kinase B-raf inhibitorCAS: 1446090-79-4 Formula: C25H17F3N4O3 Molecular Weight: 478.42Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%● In Stock — US warehouse, ships to EU* Item #: L413873View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)OC5C4C5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F
- InChIKey
- NGFFVZQXSRKHBM-FKBYEOEOSA-N
- InChI
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- Synonyms
- BGB283 | BGB-283 | CAS-338-98-7 | D11410 | BGB-283;Beigene-283 | MS-28874 | 5-{{(1r,1as,6br)-1-[5-(trifluoromethyl)-1...
- MTX-211CAS: 1952236-05-3 Formula: C2OH14Cl2FN5O2S Molecular Weight: 478.33● In Stock — US warehouse, ships to EU* Item #: M413511View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]pyridin-3-yl]methanesulfonamide
- SMILES
- CS(=O)(=O)NC1=C(N=CC(=C1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)Cl
- InChIKey
- GUYKCXXNIKKSBC-UHFFFAOYSA-N
- InChI
- 1S/C20H14Cl2FN5O2S/c1-31(29,30)28-18-7-12(9-24-19(18)22)11-2-5-17-14(6-11)20(26-10-25-17)27-13-3-4-16(23)15(21)8-13/h2-10,28H,1H3,(H,25,26,27)
- Synonyms
- Methanesulfonamide,N-[2-chloro-5-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-3-pyridinyl]- | ...
- Mobocertinib (TAK788), Inhibitor of epidermal growth factor receptorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: M422263View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
- SMILES
- CC(C)OC(=O)C1=CN=C(N=C1C2=CN(C3=CC=CC=C32)C)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
- InChIKey
- AZSRSNUQCUDCGG-UHFFFAOYSA-N
- InChI
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- Synonyms
- Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)p...
- Mobocertinib (TAK788), Inhibitor of epidermal growth factor receptorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%● In Stock — US warehouse, ships to EU* Item #: M413646View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
- SMILES
- CC(C)OC(=O)C1=CN=C(N=C1C2=CN(C3=CC=CC=C32)C)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
- InChIKey
- AZSRSNUQCUDCGG-UHFFFAOYSA-N
- InChI
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- Synonyms
- Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)p...
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
How is the EGFR listing put together?
It draws on reported EGFR annotations within JAK/STAT Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an EGFR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the EGFR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for EGFR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For EGFR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the EGFR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of EGFR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.