EGFR

Receptor tyrosine kinases (RTKs) regulate cell proliferation, survival, migration, and differentiation through tyrosine phosphorylation. RTK mutations, amplifications, fusions, or abnormal expression can continuously activate MAPK, PI3K/AKT, STAT, PLC, and other signaling pathways, thereby ...

Non-small cell lung cancer exhibits substantial histological and molecular heterogeneity. Alterations involving EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, HER2, and other oncogenic drivers can continuously activate tumor-cell proliferation and survival signaling and generate molecular subtypes with ...

HER3 strengthens PI3K/AKT survival signaling by forming heterodimers with receptors such as HER2 and EGFR and contributes to bypass compensation, maintenance of drug resistance, and tumor progression under multiple therapeutic pressures.

Protein tyrosine kinases (PTKs) transfer the γ-phosphate group of ATP to tyrosine residues on protein substrates and participate in the regulation of cell proliferation, differentiation, migration, metabolism, and survival. PTKs mainly include receptor tyrosine kinases (RTKs) and nonreceptor ...

The ErbB family pathway is a major module within receptor tyrosine kinase networks. Its key feature is not activation of a single receptor in isolation, but rather the coordinated determination of biological outcomes such as cell proliferation, survival, differentiation, and migration through ...

Erucin is an isothiocyanate compound found in cruciferous vegetables such as broccoli and arugula. Isothiocyanates are phytochemicals with diverse bioactivities, among which anticancer effects are particularly notable. Other common isothiocyanates include sulforaphane and 3-methylsulfinylpropyl ...