Inflammasomes are important cytoplasmic signaling complexes of the innate immune system that sense infection, cellular injury, and metabolic abnormalities. They activate inflammatory Caspases, promote the maturation of IL-1β and IL-18, and drive Gasdermin-mediated pyroptosis. Inflammasomes such ...
Topic
inflammasome
Techniques for detecting, quantifying and localizing antigens and antibodies — ELISA, Western blotting, immunohistochemistry and flow cytometry. Below are the protocols, FAQs and technical articles in our knowledge base tagged with this topic.
5 resources · protocols, FAQs & articles
Pyroptosis is a proinflammatory form of regulated cell death mediated by pore formation by Gasdermin family proteins. This process is generally initiated by inflammasome assembly and inflammatory caspase activation, leading to increased plasma membrane permeability, cellular swelling and ...
Neuroinflammation is an inflammatory response formed in the nervous system under conditions such as infection, injury, metabolic stress, abnormal protein deposition, or immune imbalance. Its core lies in the dynamic imbalance among microglia, astrocytes, peripheral immune cells, the blood-brain ...
Research on the cathepsin family is mainly used to elucidate mechanisms involving lysosomal proteolysis, antigen processing, cell death, matrix remodeling, and inflammatory responses. Members such as Cathepsin B, D, K, L, S, and G differ significantly in catalytic type, cellular localization, ...
Intracellular DNA sensing is not always triggered directly by exogenous pathogens. In many noninfectious stress settings, its upstream origin is first a disruption of mitochondrial metabolic homeostasis.
Related topics
Techniques often explored alongside immunological experiments.