NLRP3

Inflammasomes are important cytoplasmic signaling complexes of the innate immune system that sense infection, cellular injury, and metabolic abnormalities. They activate inflammatory Caspases, promote the maturation of IL-1β and IL-18, and drive Gasdermin-mediated pyroptosis. Inflammasomes such ...

Metabolic disorders involve multiple abnormalities, including insulin resistance, dysregulated glucose and lipid metabolism, chronic inflammation, and oxidative stress. Natural products possess diverse structural classes and molecular targets and can improve metabolic homeostasis by regulating ...

Flavonoid natural products are not merely general free-radical-scavenging constituents, but important regulatory molecules capable of acting simultaneously on reactive oxygen species generation, redox buffering, inflammatory sensing, signal transduction, and inflammatory execution.

Sphingolipid metabolism is not merely a process of membrane-lipid turnover, but an important signaling layer linking death-receptor activation, mitochondrial injury, inflammasome assembly, and cell-fate determination.