Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| Canonical Smiles | CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO |
|---|---|
| IUPAC Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol |
| InChIKey | XXSMGPRMXLTPCZ-UHFFFAOYSA-N |
| INCHI | 1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21) |
| Isomeric SMILES | CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO |
| Molecular Weight | 335.9 |
| Reaxy-Rn | 253894 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=253894&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Quinolines and derivatives |
| Subclass | Aminoquinolines and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 4-aminoquinolines |
| Alternative Parents | Chloroquinolines Secondary alkylarylamines Aminopyridines and derivatives Benzenoids Aryl chlorides Heteroaromatic compounds Trialkylamines 1,2-aminoalcohols Azacyclic compounds Primary alcohols Organopnictogen compounds Organochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Chloroquinoline - 4-aminoquinoline - Haloquinoline - Aminopyridine - Secondary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Pyridine - Benzenoid - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - 1,2-aminoalcohol - Secondary amine - Azacycle - Alkanolamine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Alcohol - Primary alcohol - Organic nitrogen compound - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system. |
| External Descriptors | tertiary amino compound - organochlorine compound - secondary amino compound - primary alcohol - aminoquinoline |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 09, 2026 | C586514 | |
| Certificate of Analysis | Jun 09, 2026 | C586514 | |
| Certificate of Analysis | Jun 09, 2026 | C586514 | |
| Certificate of Analysis | Jun 09, 2026 | C586514 | |
| Certificate of Analysis | Jun 09, 2026 | C586514 | |
| Certificate of Analysis | Nov 14, 2024 | C586514 | |
| Certificate of Analysis | Nov 14, 2024 | C586514 | |
| Certificate of Analysis | Nov 14, 2024 | C586514 | |
| Certificate of Analysis | Nov 14, 2024 | C586514 | |
| Certificate of Analysis | Nov 14, 2024 | C586514 | |
| Certificate of Analysis | Nov 14, 2024 | C586514 | |
| Certificate of Analysis | Aug 07, 2023 | C586514 | |
| Certificate of Analysis | Aug 07, 2023 | C586514 | |
| Certificate of Analysis | Aug 07, 2023 | C586514 | |
| Certificate of Analysis | Aug 07, 2023 | C586514 |
| Molecular Weight | 335.900 g/mol |
|---|---|
| XLogP3 | 3.600 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 335.176 Da |
| Monoisotopic Mass | 335.176 Da |
| Topological Polar Surface Area | 48.400 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 331.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Dai Yan, Sang Xiu-Bo, Bai Wen-Pei. (2023) N-acetylcysteine and Hydroxychloroquine Ameliorate ADMA-Induced Fetal Growth Restriction in Mice via Regulating Oxidative Stress and Autophagy. Reproductive Sciences, [PMID:37845590] [10.1007/s43032-023-01380-z] |
| 2. Mu Jiaxiang, Meng Zhaoxu, Liu Xinran, Guan Ping, Lian He. (2023) Implantable Nanofiber Membranes with Synergistic Photothermal and Autophagy Inhibition Effects for Enhanced Tumor Therapy Efficacy. Advanced Fiber Materials, [PMID:] [10.1007/s42765-023-00311-6] |
| 3. Lan-Yi Hu, Ye Yuan, Zi-Xuan Wen, Yi-Yue Hu, Miao-Miao Yin, Yan-Jun Hu. (2023) Affinity binding of COVID-19 drug candidates (chloroquine/hydroxychloroquine) and serum albumin: Based on photochemistry and molecular docking. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, [PMID:36753782] [10.1016/j.jphotobiol.2023.112667] |
| 4. Jingxiang Zhao, Zhiqiang Zhao, Wanting Hou, Yue Jiang, Guobin Liu, Xuelian Ren, Kun Liu, Hong Liu, Kaixian Chen, He Huang. (2022) Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine. MOLECULES, 27 (16): (5175). [PMID:36014414] [10.3390/molecules27165175] |
| 5. Zhang Man, Bai Yang, Xu Chang, Qi Yiying, Meng Jiahong, Zhang Wenkan, Su Hang, Yan Weiqi. (2021) Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma. Frontiers in Cell and Developmental Biology, [PMID:34414176] [10.3389/fcell.2021.650846] |
| 6. Rongliang Wang, Jiawei Li, Xingquan Xu, Jia Xu, Huiming Jiang, Zhongyang Lv, Rui Wu, Ziying Sun, Wenjie Guo, Yang Sun, Shiro Ikegawa, Qing Jiang, Dongquan Shi. (2021) Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model. Journal of Orthopaedic Translation, [PMID:34094861] [10.1016/j.jot.2021.05.001] |
| 7. Xingquan Xu, Rongliang Wang, Rui Wu, Wenjin Yan, Tianshu Shi, Qing Jiang, Dongquan Shi. (2020) Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation. FASEB JOURNAL, 34 (6): (8402-8415). [PMID:32367591] [10.1096/fj.201902528RRR] |
| 8. Chen Ping, Zhang Xueer, Fang Qiaomiao, Zhao Zhongxiang, Lin Chaozhan, Zhou Yuan, Liu Fangle, Zhu Chenchen, Wu Aizhi. (2024) Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo. Journal of Natural Medicines, [PMID:38403724] [10.1007/s11418-024-01782-6] |
| 9. Boqiang Gao, Haoge Liang, Jie Wang, Yan Huang, Jingzhen Wang, Jia Song, Pan Hu, Hu Yang, Shuanglong Ma. (2024) Efficient adsorption of hydroxychloroquine by carboxylated lignin-based sponge: Quantification of the adsorption contribution of interactions. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.129359] |
| 10. Zhipeng Zhang, Huizi Zheng, Ying Liu, Shuang Ma, Qi Feng, Jiao Qu, Xiaolin Zhu. (2024) Highly sensitive detection of multiple antiviral drugs using graphitized hydroxylated multi-walled carbon nanotubes/ionic liquids-based electrochemical sensors. ENVIRONMENTAL RESEARCH, [PMID:38354882] [10.1016/j.envres.2024.118466] |
| 11. Linming Li, Yan Chen, Ming Zhang, Suying Li, Shuaiqi Feng, Yan-Qin He, Ning Zhang, Zhifang Liu, Meifeng Liu, Qing-Peng Wang. (2024) Hydroxychloroquine Platinum(IV) Conjugate Displaying Potent Antimetastatic Activities by Suppressing Autophagy to Improve the Tumor Microenvironment. DALTON TRANSACTIONS, [PMID:39092626] [10.1039/D4DT01794C] |
| 12. Kejie Wang, Bingye Shi, Yihui Chen, Chunyan Hou, Xie Li, Xiaoqiang Qiao, Tingting Wang. (2025) Synthesis of Perfluorooctyl-Functionalized Halloysite Nanotubes for Dispersive Solid-Phase Extraction of Antimalarial Inhibitors in Whole Blood. JOURNAL OF SEPARATION SCIENCE, 48 (7): (e70226). [PMID:40650450] [10.1002/jssc.70226] |
| 13. Yu Wang, Hongrui Fan, Qinjun Chen, Haolin Song, Xuwen Li, Boyu Su, Tao Sun, Leilei Cheng, Chen Jiang. (2025) Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual disruption of pyrimidine synthesis and redox homeostasis in pancreatic ductal adenocarcinoma. BIOMATERIALS, [PMID:40818322] [10.1016/j.biomaterials.2025.123630] |
| 14. Chen Yun-Ting, Han Jing-Wen, Yu Zi-Wei, Yang Ruo-Yu, Wu Mei-Juan, Huang Pin-Fang, Liu Meng-Meng. (2025) Smartphone-assisted portable immunosensor toward on-site detection of tumor necrosis factor-α inhibitor adalimumab for personalized treatment. MICROCHIMICA ACTA, 192 (6): (1-11). [PMID:40404886] [10.1007/s00604-025-07230-w] |
| 15. Xu Lian, Chen Jiangwei, Zhang Wenli, Du Qianying, Huang Xin, Luo Ying, Wang Yi, Chen Sijin, Rong Xiyue, Liu Jia, Xu Zhongsheng, Ran Haitao, Liu Yun, Guo Dajing, Xu Jie. (2025) A bismuth-based nanoplatform with synergistic fibrin/NET disruption and antioxidant/anti-inflammatory capabilities for enhanced thrombolysis and prevention of deep vein thrombosis recurrence. JOURNAL OF NANOBIOTECHNOLOGY, [PMID:41299690] [10.1186/s12951-025-03864-3] |
| 16. Qiu Yueping, Liu Yijie, Ding Haiying, Xin Wenxiu, Lu Shuanghui, Hu Yan, Chen Jing, Weng Qinjie, Wang Jiajia, Fang Luo. (2026) Osimertinib activates TFEB to trigger hepatocyte cytoplasmic vacuolation-associated cell death. Cell Communication and Signaling, [PMID:41612351] [10.1186/s12964-026-02688-4] |
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View Moligand™ grade guide →