Apolipoprotein H (APOH)

Cat. No.: A1526735

GRADE & PURITY BioReagent, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Overview

Apolipoprotein H, also known as β2Glycoprotein-1 (β2GP-1) is a plasma glycoprotein that circulates at a concentration of 200 µg/mL (4mM). β2GP-1 has been identified as a constituent of chylomicrons, very low density lipoproteins and high density lipoproteins in Human plasma. It has also been demonstrated to bind phospholipids, heparin and platelets where it can modulate the activity of adenylate (19%). Although the precise function(s) are as yet unknown, β2GP-1 has been shown to interfere with blood coagulation by competitively binding to phospholipids exposed during cell activation or damage. Recent evidence also implicates β2GP-1 as a cofactor recognized by some anti-phospholipid antibodies present in autoimmune disorders such as systemic lupus erythematosus(SLE). Extinction Coefficient (1%) = 9.4 Molecular Weight = 48,000 daltons The above protein was purified from human plasma via ion and affinity column chromatography. It is >95% pure on SDS-PAGE. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.

Specifications

Product Name

Apolipoprotein H (APOH)

Grade

BioReagent

Specifications & Purity

BioReagent, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Molecule Type

Protein

Storage and Shipping

Concentration

from Human plasma; Protein concentration: See COA

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs