10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
AZ1 is a potent and noncompetitive dual Inhibitors of theubiquitin-specific protease (USP) 25/28with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.
Targets
USP25 (Cell-free assay); USP28 (Cell-free assay) 0.62 μM; 0.7 μM
In vitro
AZ1 is able to reduce cell viability across a range of cancer cell lines with EC50 values typically clustered around 20 μM.
| ALogP | 4.291 |
|---|---|
| HBD Count | 2 |
| Rotatable Bond | 8 |
| Pubchem Sid | 528767599 |
|---|---|
| Canonical Smiles | C1=CC(=C(C=C1COC2=C(C=C(C=C2)Br)CNCCO)C(F)(F)F)F |
| IUPAC Name | 2-[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methylamino]ethanol |
| InChIKey | ITHSFXDGKQYOED-UHFFFAOYSA-N |
| INCHI | 1S/C17H16BrF4NO2/c18-13-2-4-16(12(8-13)9-23-5-6-24)25-10-11-1-3-15(19)14(7-11)17(20,21)22/h1-4,7-8,23-24H,5-6,9-10H2 |
| Isomeric SMILES | C1=CC(=C(C=C1COC2=C(C=C(C=C2)Br)CNCCO)C(F)(F)F)F |
| PubChem CID | 135397656 |
| Molecular Weight | 422.21 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Trifluoromethylbenzenes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Trifluoromethylbenzenes |
| Alternative Parents | Phenoxy compounds Phenol ethers Fluorobenzenes Bromobenzenes Alkyl aryl ethers Dialkylamines Alkanolamines Organopnictogen compounds Organofluorides Organobromides Hydrocarbon derivatives Alkyl fluorides Alcohols and polyols |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Trifluoromethylbenzene - Phenoxy compound - Phenol ether - Halobenzene - Fluorobenzene - Bromobenzene - Alkyl aryl ether - Secondary amine - Ether - Secondary aliphatic amine - Alkanolamine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organobromide - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Alcohol - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene ring substituted with one or more trifluoromethyl groups. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| DMSO(mg / mL) Max Solubility | 84 |
|---|---|
| DMSO(mM) Max Solubility | 198.953127590536 |
| Water(mg / mL) Max Solubility | ＜1 |
| Molecular Weight | 422.200 g/mol |
| XLogP3 | 3.700 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 7 |
| Exact Mass | 421.03 Da |
| Monoisotopic Mass | 421.03 Da |
| Topological Polar Surface Area | 41.500 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 399.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
