L-Norepinephrine hydrochloride - Moligand™, ≥98% , CAS No.329-56-6

CAS: 329-56-6 Cat. No.: L335487 Molecular Weight: 205.64 EC Number: 206-345-5

GRADE & PURITY Moligand™, ≥98%

Synonyms

1,2-BENZENEDIOL, 4-((1R)-2-AMINO-1-HYDROXYETHYL)-, HYDROCHLORIDE (1:1) | 329-56-6 (HCl) | ATERENOL | NORADRENALINE HYDROCHLORIDE [EP MONOGRAPH] | UNII-4W6461XR05 | (-)-Noradrenaline hydrochloride | HY-13715A | Nor-adrenalin hydrochloride | NORADRENALINE H

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

L-Norepinephrine hydrochloride is an adrenal medullary stress hormone, which mediates the fight-or-flight response. It is the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) nervous system.

Specifications

Synonyms

1, 2-BENZENEDIOL, 4-((1R)-2-AMINO-1-HYDROXYETHYL)-, HYDROCHLORIDE (1:1) | 329-56-6 (HCl) | ATERENOL | NORADRENALINE HYDROCHLORIDE [EP MONOGRAPH] | UNII-4W6461XR05 | (-)-Noradrenaline hydrochloride | HY-13715A | Nor-adrenalin hydrochloride | NORADRENALINE H

Specifications & Purity

Moligand™, ≥98%

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504766638
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504766638
• Canonical Smiles: C1=CC(=C(C=C1C(CN)O)O)O.Cl
• IUPAC Name: 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;hydrochloride
• InChIKey: FQTFHMSZCSUVEU-QRPNPIFTSA-N
• INCHI: 1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1
• Isomeric SMILES: C1=CC(=C(C=C1[C@H](CN)O)O)O.Cl
• UN Number: UN2811
• Packing Group: I
• Molecular Weight: 205.64
• Reaxy-Rn: 4211089
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4211089&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Phenols
      • Subclass Benzenediols

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Phenols
• Subclass: Benzenediols
• Intermediate Tree Nodes: Not available
• Direct Parent: Catechols
• Alternative Parents: Aralkylamines 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Secondary alcohols 1,2-aminoalcohols Monoalkylamines Hydrochlorides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - 1,2-aminoalcohol - Secondary alcohol - Organic nitrogen compound - Aromatic alcohol - Hydrochloride - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxygen compound - Amine - Alcohol - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as catechols. These are compounds containing a 1,2-benzenediol moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Moisture sensitive；air sensitive；light sensitive
• Melt Point(°C): 150° C (dec.)
• Molecular Weight: 205.640 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 205.051 Da
• Monoisotopic Mass: 205.051 Da
• Topological Polar Surface Area: 86.700 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 142.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Wei Luo, Teris A. van Beek, Bo Chen, Han Zuilhof, Gert IJ. Salentijn.  (2022)  Boronate affinity paper spray mass spectrometry for determination of elevated levels of catecholamines in urine.  ANALYTICA CHIMICA ACTA,      [PMID:36368818] [10.1016/j.aca.2022.340508]

2. He Maofang, Wei Yinmao, Wang Rong, Wang Chunyang, Zhang Bo, Han Lu.  (2019)  Boronate affinity magnetic nanoparticles with hyperbranched polymer brushes for the adsorption of cis-diol biomolecules.  MICROCHIMICA ACTA,  186  (10): (1-9).  [PMID:31529296] [10.1007/s00604-019-3785-y]

3. Yushuang Guo, Mingli Chen, Ting Yang, Jianhua Wang.  (2023)  Ratio-Metric Fluorescence/Colorimetric and Smartphone-Assisted Visualization for the Detection of Dopamine Based on Cu-MOF with Catecholase-like Activity.  Chemosensors,  11  (8): (431).  [PMID:] [10.3390/chemosensors11080431]