SphK

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  1. N,N-Dimethyl-D-erythro-sphingosine (PKC inhibitor)
    CAS: 119567-63-4 Formule: C20H41NO2 Poids moléculaire: 327.5
    ◐ .Sur commande · 8–12 semaines Article #: N274922
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    Nom IUPAC
    (E,2S,3R)-2-(dimethylamino)octadec-4-ene-1,3-diol
    SMILES
    CCCCCCCCCCCCCC=CC(C(CO)N(C)C)O
    InChIKey
    YRXOQXUDKDCXME-YIVRLKKSSA-N
    InChI
    1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
    Synonymes
    SR-01000946568-1 | CHEBI:78759 | N,N-Dimethyl-D-erythrosphingenine | NCGC00161359-01 | BSPBio_001420 | (2S,3R,4E)-2-(...
  2. SLM 6031434 hydrochloride
    CAS: 1897379-34-8 PubChem CID: 134812833 Formule: C₂₂H₃₀F₃N₅O₂.HCl Poids moléculaire: 489.96
    ◐ .Sur commande · 8–12 semaines Article #: S288509
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    Nom IUPAC
    (2S)-2-[3-[4-octoxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochloride
    SMILES
    CCCCCCCCOC1=C(C=C(C=C1)C2=NOC(=N2)C3CCCN3C(=N)N)C(F)(F)F.Cl
    InChIKey
    YIGAQKBPLMSWOD-LMOVPXPDSA-N
    InChI
    1S/C22H30F3N5O2.ClH/c1-2-3-4-5-6-7-13-31-18-11-10-15(14-16(18)22(23,24)25)19-28-20(32-29-19)17-9-8-12-30(17)21(26)27;/h10-11,14,17H,2-9,12-13H2,1H3,(Hshow more
    Synonymes
    (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
  3. MP A08, Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
    CAS: 219832-49-2 Formule: C27H25N3O4S2 Poids moléculaire: 519.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: M288047
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    Nom IUPAC
    4-methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide
    SMILES
    CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C=NC3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)C
    InChIKey
    FLDBNMYJUMAXDQ-UHFFFAOYSA-N
    InChI
    1S/C27H25N3O4S2/c1-20-11-15-23(16-12-20)35(31,32)29-25-8-4-3-7-22(25)19-28-26-9-5-6-10-27(26)30-36(33,34)24-17-13-21(2)14-18-24/h3-19,29-30H,1-2H3
    Synonymes
    NSC 122314 | 4-Méthyl-N-[2-[[2-[(4-méthylphényl)sulfonyl]amino]phényl]imino]méthyl]phényl]benzènesulfonamide | MP-A08
  4. PF 543 hydrochloride
    CAS: 1706522-79-3 PubChem CID: 121230770 Formule: C27H31NO4S•HCl Poids moléculaire: 502.07
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: P286792
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    Nom IUPAC
    [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol;hydrochloride
    SMILES
    CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4.Cl
    InChIKey
    WNKWAZFYPZMDGJ-VQIWEWKSSA-N
    InChI
    1S/C27H31NO4S.ClH/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;/h2-4,7-12,14-16,25,29H,5-6,1show more
    Synonymes
    (2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2- pyrrolidinemethanol hydrochloride
  5. PF-543, Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
    CAS: 1415562-82-1 Formule: C27H31NO4S Poids moléculaire: 465.6
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: P125702
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    Nom IUPAC
    [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol
    SMILES
    CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4
    InChIKey
    NPUXORBZRBIOMQ-RUZDIDTESA-N
    InChI
    1S/C27H31NO4S/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29/h2-4,7-12,14-16,25,29H,5-6,13,17-show more
    Synonymes
    DTXSID3063386 | BDBM50041978 | (2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrol...
  6. ABC294640, Sphingosine kinase 2 inhibitor
    CAS: 915385-81-8 Formule: C23H25ClN2O Poids moléculaire: 380.91
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: A127517
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    Nom IUPAC
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
    SMILES
    C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl
    InChIKey
    CAOTVXGYTWCKQE-UHFFFAOYSA-N
    InChI
    1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
    Synonymes
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide | ABC294640 | ABC-294640 | BA162479 | BDBM50393642 ...
  7. SKI II, Inhibitor of delta 4-desaturase; sphingolipid 1;Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
    CAS: 312636-16-1 PubChem CID: 753704 Formule: C15H11ClN2OS Poids moléculaire: 302.78
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: S129855
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    Identificateurs techniques
    Nom IUPAC
    4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
    SMILES
    C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
    InChIKey
    ZFGXZJKLOFCECI-UHFFFAOYSA-N
    InChI
    1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
    Synonymes
    CCG-265019 | HMS3413G03 | SKI II | Ski ii (sphk-i2) | HMS3650M12 | NCGC00092309-01 | SKI 2 | BDBM50312869 | HMS3677G0...
  8. SKI-I
    CAS: 306301-68-8 PubChem CID: 137269090 Formule: C25H18N4O2 Poids moléculaire: 406.44
    ◐ .Sur commande · 8–12 semaines Article #: S275155
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    Nom IUPAC
    N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-5-naphthalen-2-ylpyrazolidine-3-carboxamide
    SMILES
    C1C(NNC1C(=O)NN=CC2=C(C=CC3=CC=CC=C32)O)C4=CC5=CC=CC=C5C=C4
    InChIKey
    LMCALHGHWCFFHD-CVKSISIWSA-N
    InChI
    1S/C25H22N4O2/c30-24-12-11-17-6-3-4-8-20(17)21(24)15-26-29-25(31)23-14-22(27-28-23)19-10-9-16-5-1-2-7-18(16)13-19/h1-13,15,22-23,27-28,30H,14H2,(H,29,show more
    Synonymes
    5-(2-Naphthalenyl)-1H-pyrazole-3-carboxylicacid2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
  9. oméga-biotinyl D-érythro-sphingosine
    CAS: 752987-57-8 PubChem CID: 46891739 Formule: C28H52N4O4S Poids moléculaire: 540.802
    ◐ .Sur commande · 8–12 semaines Article #: O130651
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    Nom IUPAC
    5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[(E,16R,17S)-17-amino-16,18-dihydroxyoctadec-14-enyl]pentanamide
    SMILES
    C1C2C(C(S1)CCCCC(=O)NCCCCCCCCCCCCCC=CC(C(CO)N)O)NC(=O)N2
    InChIKey
    NYQVYZZGZCNEMF-RPRIXWAOSA-N
    InChI
    1S/C28H52N4O4S/c29-22(20-33)24(34)16-12-10-8-6-4-2-1-3-5-7-9-11-15-19-30-26(35)18-14-13-17-25-27-23(21-37-25)31-28(36)32-27/h12,16,22-25,27,33-34H,1-1show more
  10. ABC294640, Sphingosine kinase 2 inhibitor
    CAS: 915385-81-8 Formule: C23H25ClN2O Poids moléculaire: 380.91
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: A426910
    Voir le produit
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    Identificateurs techniques
    Nom IUPAC
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
    SMILES
    C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl
    InChIKey
    CAOTVXGYTWCKQE-UHFFFAOYSA-N
    InChI
    1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
    Synonymes
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide | ABC294640 | ABC-294640 | BA162479 | BDBM50393642 ...
  11. CAY10621 (SKI 5C)
    CAS: 120005-55-2 Formule: C26H45NO4 Poids moléculaire: 435.65
    ◐ .Sur commande · 8–12 semaines Article #: C276256
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    Nom IUPAC
    tert-butyl (4S)-4-hexadec-2-ynoyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
    SMILES
    CCCCCCCCCCCCCC#CC(=O)C1COC(N1C(=O)OC(C)(C)C)(C)C
    InChIKey
    YGBSGZPIDCXNEH-QFIPXVFZSA-N
    InChI
    1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1
    Synonymes
    tert-Butyl(4S)-4-hexadec-2-ynoyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
  12. Defensamide (MHP)
    CAS: 1104874-94-3 Formule: C16H23NO4   Poids moléculaire: 293.36
    10mM in DMSO
    ● En stock — Entrepôt aux États-Unis, expédition vers l'EU* Article #: D420603
    Voir le produit
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    Nom IUPAC
    methyl (2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoate
    SMILES
    CCCCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)OC
    InChIKey
    GBTVWZMJUZJPBU-AWEZNQCLSA-N
    InChI
    1S/C16H23NO4/c1-3-4-5-6-15(19)17-14(16(20)21-2)11-12-7-9-13(18)10-8-12/h7-10,14,18H,3-6,11H2,1-2H3,(H,17,19)/t14-/m0/s1
    Synonymes
    ZB1539 | (S)-Methyl 2-(hexanamido)-3-(4-hydroxyphenyl)propanoate | (S)-methyl 2-hexanamido-3-(4-hydroxyphenyl)propano...
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Foire aux questions

What can I find under SphK?
This listing collects compounds associated with SphK within our Immunology/Inflammation area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for SphK?
Consider the reported potency of each SphK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for SphK compounds?
Each SphK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search SphK compounds by activity or structure?
Yes. Filter the SphK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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