Pepstatin, CAS No.26305-03-3

CAS: 26305-03-3 Cat. No.: P113168 Molecular Weight: 685.89 Beilstein Registry Number: 2201362 EC Number: 247-600-0
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥75%(HPLC)
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1mg
P113168-1mg
3
$15.90
5mg
P113168-5mg
4
$54.90
10mg
P113168-10mg
3
$73.90
25mg
P113168-25mg
1
$107.90
50mg
P113168-50mg
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$183.90
100mg
P113168-100mg
1
$326.90
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Why this grade

Moligand™, ≥75%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.
An inhibitor of HIV-1 and aspartic proteases. Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.

Specifications

Product Name
Pepstatin, CAS No.26305-03-3
Synonyms
EX-A4027 | MLS000069747 | PEPSTATIN [INN] | 4er2 | AC-8820 | KBioGR_000340 | MLS006010748 | NCGC00161670-06 | Procidin S 735A | Q7166509 | UNII-U56LDN9FFT | UPCMLD-DP141:002 | WLN: QR BQ DQ EV3 | (3S, 4S)-3-hydroxy-4-[(2S)-2-[(3S, 4S)-3-hydroxy-6-methyl-4-[
Grade
Moligand™
Specifications & Purity
Moligand™, ≥75%(HPLC)
Biochemical and Physiological Mechanisms
Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thio
Sequence
Isovaleryl-Val-Val-Sta-Ala-Sta
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
CAS
26305-03-3
Molecule Type
Peptide
Storage and Shipping
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassPeptidomimetics
SubclassHybrid peptides
Intermediate Tree Nodes Not available
Direct ParentHybrid peptides
Alternative Parents Dipeptides  Valine and derivatives  N-acyl-alpha amino acids and derivatives  Alpha amino acid amides  Gamma amino acids and derivatives  Alanine and derivatives  Medium-chain hydroxy acids and derivatives  Medium-chain fatty acids  Amino fatty acids  Beta hydroxy acids and derivatives  Methyl-branched fatty acids  Hydroxy fatty acids  N-acyl amines  Secondary carboxylic acid amides  Secondary alcohols  Monocarboxylic acids and derivatives  Carboxylic acids  Carbonyl compounds  Organopnictogen compounds  Organic oxides  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents Hybrid peptide - Alpha-dipeptide - N-acyl-alpha amino acid or derivatives - Valine or derivatives - Alpha-amino acid amide - Gamma amino acid or derivatives - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Medium-chain hydroxy acid - Medium-chain fatty acid - Amino fatty acid - Beta-hydroxy acid - Hydroxy fatty acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acyl - Fatty acid - Fatty amide - N-acyl-amine - Hydroxy acid - Secondary carboxylic acid amide - Carboxamide group - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organic nitrogen compound - Carbonyl group - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CTSL Tclin Cathepsin L1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CTSE Tchem Cathepsin E (8 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PGA5 Tclin Pepsin A-5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
REN Tclin Renin (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CTSD Tchem Cathepsin D (14 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADAM9 Tchem Disintegrin and metalloproteinase domain-containing protein 9 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSD Tchem Cathepsin D (3201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSB Tchem Cathepsin B (3822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
REN Tclin Renin (5251 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSH Tchem Cathepsin H (179 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTRC Tchem Chymotrypsin C (381 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSE Tchem Cathepsin E (189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADAM9 Tchem ADAM9 (81 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NHDF (1164 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBMC (10003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
pol Human immunodeficiency virus type 1 protease (9113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSL Cathepsin L (58 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGA Pepsin A (436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMI Plasmepsin 1 (207 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMII Plasmepsin 2 (774 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
gag-pro Human T-cell leukemia virus type I protease (57 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cysteine protease (30 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Genome polyprotein (620 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Protease (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP2 Candidapepsin-2 (159 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP8 Candidapepsin-8 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP3 Candidapepsin-3 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP5 Candidapepsin-5 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP1 Candidapepsin-1 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP9 Candidapepsin-9 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP6 Candidapepsin-6 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SAP4 Candidapepsin-4 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmepsin 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

47 results found

Lot NumberCertificate TypeDateItem
C2613375Certificate of AnalysisFeb 25, 2026 P113168
C2613365Certificate of AnalysisFeb 25, 2026 P113168
C2613364Certificate of AnalysisFeb 25, 2026 P113168
C2613319Certificate of AnalysisFeb 25, 2026 P113168
C2613318Certificate of AnalysisFeb 25, 2026 P113168
D2419557Certificate of AnalysisJan 20, 2026 P113168
D2419554Certificate of AnalysisJan 20, 2026 P113168
A2607095Certificate of AnalysisJan 12, 2026 P113168
C2228050Certificate of AnalysisOct 11, 2025 P113168
J2326476Certificate of AnalysisJul 10, 2025 P113168
F2527608Certificate of AnalysisJun 04, 2025 P113168
F2527188Certificate of AnalysisJun 04, 2025 P113168
F2527185Certificate of AnalysisJun 04, 2025 P113168
F2527179Certificate of AnalysisJun 04, 2025 P113168
F2310482Certificate of AnalysisMar 04, 2025 P113168
F2310480Certificate of AnalysisMar 04, 2025 P113168
F2310496Certificate of AnalysisMar 04, 2025 P113168
F2310492Certificate of AnalysisMar 04, 2025 P113168
F2310487Certificate of AnalysisMar 04, 2025 P113168
F2310491Certificate of AnalysisMar 04, 2025 P113168
C2331045Certificate of AnalysisJan 08, 2025 P113168
C2519039Certificate of AnalysisJan 03, 2025 P113168
C2517503Certificate of AnalysisJan 03, 2025 P113168
C2517502Certificate of AnalysisJan 03, 2025 P113168
C2517501Certificate of AnalysisJan 03, 2025 P113168
L2206598Certificate of AnalysisSep 03, 2024 P113168
L2206589Certificate of AnalysisSep 03, 2024 P113168
I2410133Certificate of AnalysisAug 23, 2024 P113168
I2410134Certificate of AnalysisAug 23, 2024 P113168
I2410135Certificate of AnalysisAug 23, 2024 P113168
D2419556Certificate of AnalysisMar 30, 2024 P113168
D2419555Certificate of AnalysisMar 30, 2024 P113168
D2419553Certificate of AnalysisMar 30, 2024 P113168
C2228042Certificate of AnalysisJan 05, 2024 P113168
C2415121Certificate of AnalysisOct 10, 2023 P113168
J2326477Certificate of AnalysisOct 10, 2023 P113168
J2326478Certificate of AnalysisOct 10, 2023 P113168
J2326501Certificate of AnalysisOct 10, 2023 P113168
K21171172Certificate of AnalysisAug 10, 2023 P113168
K21171171Certificate of AnalysisAug 10, 2023 P113168
F2310483Certificate of AnalysisMay 26, 2023 P113168
F2310484Certificate of AnalysisMay 26, 2023 P113168
E2110113Certificate of AnalysisFeb 10, 2023 P113168
L2206567Certificate of AnalysisOct 25, 2022 P113168
L2206587Certificate of AnalysisOct 25, 2022 P113168
L2206588Certificate of AnalysisOct 25, 2022 P113168
C2228036Certificate of AnalysisFeb 18, 2022 P113168

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Documents & Articles
Advanced enzyme analysis technology
Protein sample preparation process
BN-PAGE Protocol
Dual Cross-linking ChIP Protocol
Protease Inhibitors
How to Optimize Buffer Components for Ni-Agarose Beads
Pepsin——Structural Features, Enzymatic Properties, and Experimental Application Guide
Review of Chymotrypsin: Enzymological Properties, Catalytic Mechanism, and Research Applications
Review of Collagenase: Enzymological Features, Type Systems, and Research Applications
Roles of the Carboxypeptidase Family in Protein C-Terminal Processing and Experimental Analysis
Citations of This Product
References
1. Jiandong Shen, Wei Zhang, Qixing Jiang, Pei Gao, Yanshun Xu, Wenshui Xia.  (2022)  The role of cathepsin L on structural changes of collagen fibers involved in textural deterioration of chilled grass carp (Ctenopharyngodon idella) fillets.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  102  (13): (5858-5866).  [PMID:35426126] [10.1002/jsfa.11935]
2. Lili Zhao, Shuhua Zhu, Jie Zhou.  (2012)  A novel amperometric nitric oxide sensor based on imprinted microenvironments for controlling metal coordination.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2012.05.035]
3. Wang Zilin, Tian Yang, Yang Min, Yang Junyan, Wang Yifan, Tao Liang, Sheng Jun, Shi Chongying.  (2024)  Extraction of phenolic compounds from Moringa oleifera Lam. leaves with ultrasonic-assisted deep eutectic solvents.  Frontiers in Nutrition,      [PMID:39193562] [10.3389/fnut.2024.1405128]
4. Rongrong He, Ziwei Lv, Yinan Li, Shuchao Ren, Jiaqi Cao, Jun Zhu, Xinrong Zhang, Huimin Wu, Lihao Wan, Ji Tang, Shutong Xu, Xiao-Lin Chen, Zhipeng Zhou.  (2024)  tRNA-m1A methylation controls the infection of Magnaporthe oryzae by supporting ergosterol biosynthesis.  DEVELOPMENTAL CELL,      [PMID:39191251] [10.1016/j.devcel.2024.08.002]
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