Tiopronin - Moligand™,10mM in DMSO , Reducing agent, CAS No.1953-02-2, Reducing agent

CAS: 1953-02-2 Cat. No.: T408799 Molecular Weight: 163.19 EC Number: 217-778-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

N-​(2-​mercapto-​1-​oxopropyl)​-glycine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
In vitro

Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. Tiopronin improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. Tiopronin (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. Tiopronin also significantly protects the renal slices from cisplatin-induced toxic effects. Tiopronin protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. Tiopronin protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. Tiopronin provides marked protection againstcisplatin-induced increases in urea and creatinine. Tiopronin protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices.

In vivo

Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. Tiopronin significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

N-​(2-​mercapto-​1-​oxopropyl)​-glycine

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Mechanism of action

Reducing agent

Product Properties

• ALogP: -0.1

Names and Identifiers

• Isomeric SMILES: CC(C(=O)NCC(=O)O)S
• Molecular Weight: 163.19
• Reaxy-Rn: 1859822
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1859822&ln=

Chemical and Physical Properties

• Melt Point(°C): 98°C

References

1. Cheng Zhang, Mengna Liang, Congying Shao, Ziwei Li, Xue Cao, Yongxiang Wang, Yanan Wu, Shun Lu.  (2023)  Visual Detection and Sensing of Mercury Ions and Glutathione Using Fluorescent Copper Nanoclusters.  ACS Applied Bio Materials,      [PMID:36788220] [10.1021/acsabm.3c00031]

2. Xinli Li, Mengru Chen, Yanbao Zhao, Lei Sun.  (2021)  Redox/pH/NIR-responsive degradable silica nanospheres with fluorescence for drug release and photothermal therapy.  BIOCHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.bej.2021.107955]

3. Tian Ruochen, Suo Hao, Zhang Shuting, Sun Baoshan.  (2020)  Separation of a family of antioxidants flavan-3-ol thio-conjugates from procyanidins by high-speed counter-current chromatography.  EUROPEAN FOOD RESEARCH AND TECHNOLOGY,  246  (5): (1017-1029).  [PMID:] [10.1007/s00217-020-03465-4]

4. Haiqin Wu, Lan Jin.  (2016)  Assembly of alizarin red S/boric acid ultrathin films based on layered double hydroxide for fluorescence turn on detection of tiopronin.  Journal of Materials Chemistry C,  4  (16): (3415-3421).  [PMID:] [10.1039/C5TC04405G]

5. Xiupei Yang, Jing Yang, Maoxue Zhang, Ya Wang, Baowen Zhang, Xiaolin Mei.  (2021)  Tiopronin protected gold-silver bimetallic nanoclusters for sequential detection of Fe3+ and ascorbic acid in serum.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2021.107048]

6. Xiujuan Jiang, Hailong Wang, Yonggang Feng, Erxing Gu, Xiaoming Liu.  (2017)  Electrochemically probing the correlation between photo-induced CO-releasing behaviours and their LUMO energies of three diiron carbonyl complexes.  INORGANICA CHIMICA ACTA,      [PMID:] [10.1016/j.ica.2017.04.053]

7. Hao Tang, Xiaomeng Zhao, Mengsi Sun, Jie Qi, Zhihao Huang, Yihang Zhu, Yingmin Zeng, Yong Xia, Zhi Luo, Xingyu Jiang.  (2025)  Chemically tailored anionic antibiotic adjuvants targeting divalent cations to overcome carbapenem resistance in gram-negative bacteria.  Science Advances,  11  (43):   [PMID:41124267] [10.1126/sciadv.adz0574]