3-Maleimidopropionic Acid - 10mM in DMSO , CAS No.7423-55-4

CAS: 7423-55-4 Cat. No.: M425780 Molecular Weight: 169.13 Beilstein Registry Number: 1528952 EC Number: 616-069-0
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GRADE & PURITY 10mM in DMSO
Synonyms
AM20100720 | FT-0604091 | MFCD00043030 | N-(2-Carboxyethyl)maleimide | PD134103 | DTXSID00341526 | STK934575 | 3-(2,5-dioxopyrrol-1-yl)propanoic acid | 3-Maleimidopropionic acid | 3-maleimido-propionic acid | .BETA.-MALEIMIDOPROPIONIC ACID | EN300-227402
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
Size
Status
Price
Qty
1ml
M425780-1ml
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

N-Maleoyl-β-alanine (3- maleimide propionic acid) is an aliphatic N-substituted maleimide. It is one of the components of EC145 (a folate-targeted vinca alkaloid conjugate) stable solution used for pharmacokinetic study of rodents.

N-Maleoyl-β-alanine (3- maleimide propionic acid, N -(2- carboxyethyl) maleimide) is a suitable reagent used in the following research:

The biotin binding affinity of Avd (S16C) (avidin with single point mutation S16C) was decreased.

As a side chain reaction agent, the trypsin peptide was modified, resulting in mass shift, indicating the presence of cysteine residues.

Cysteine exposed by Xenopus oocytes was blocked in advance and used as an expression system to study the conformational changes of cASIC1a receptor.

It can be used for the following research:

As a protective agent for keratin fibers in high temperature process.

As an unbreakable maleimide group in the synthesis process of four-walled molecular umbrella-octa-arginine conjugate.

Synthesis of N-Maleoyl-β-Organotin Carboxylate-Alanine.

Interaction between functionalized gold surface and cysteine modified peptide.

Preparation of crosslinked dextran-polyethylene glycol hydrogel matrix.

Specifications

Synonyms
AM20100720 | FT-0604091 | MFCD00043030 | N-(2-Carboxyethyl)maleimide | PD134103 | DTXSID00341526 | STK934575 | 3-(2, 5-dioxopyrrol-1-yl)propanoic acid | 3-Maleimidopropionic acid | 3-maleimido-propionic acid | .BETA.-MALEIMIDOPROPIONIC ACID | EN300-227402
Specifications & Purity
10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Canonical SmilesC1=CC(=O)N(C1=O)CCC(=O)O
IUPAC Name3-(2,5-dioxopyrrol-1-yl)propanoic acid
InChIKeyIUTPJBLLJJNPAJ-UHFFFAOYSA-N
INCHI1S/C7H7NO4/c9-5-1-2-6(10)8(5)4-3-7(11)12/h1-2H,3-4H2,(H,11,12)
Isomeric SMILES C1=CC(=O)N(C1=O)CCC(=O)O
WGK Germany 3
Molecular Weight 169.13
Beilstein 1528952
Reaxy-Rn 1528952
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1528952&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassPyrrolidines
SubclassPyrrolidones
Intermediate Tree Nodes Not available
Direct ParentMaleimides
Alternative Parents N-substituted carboxylic acid imides  Pyrrolines  Dicarboximides  Monocarboxylic acids and derivatives  Carboxylic acids  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Maleimide - Carboxylic acid imide, n-substituted - Carboxylic acid imide - Dicarboximide - Pyrroline - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Carbonyl group - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as maleimides. These are compounds containing a 2,5-pyrroledione moiety.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityMoisture Sensitive
Melt Point(°C)110°C
Molecular Weight169.130 g/mol
XLogP30.000
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass169.038 Da
Monoisotopic Mass169.038 Da
Topological Polar Surface Area74.700 Ų
Heavy Atom Count12
Formal Charge0
Complexity251.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Chongzheng Yan, Ying Liu, Guozhi Zhao, Huatian Yang, Huaiyou Lv, Genju Li, Yuhan Li, Yaqing Fu, Fengqin Sun, Yafei Feng, Yizhe Li, Zhongxi Zhao.  (2024)  Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy.  Acta Pharmaceutica Sinica B,      [PMID:38799628] [10.1016/j.apsb.2024.01.017]
2. Peng Ding, Yanfang Sun, Guohua Jiang, Lei Nie.  (2025)  Hydroxyproline-Modified Chitosan-Based Hydrogel Dressing Incorporated with Epigallocatechin-3-Gallate Promotes Wound Healing Through Immunomodulation.  Gels,  11  (9): (732).  [PMID:41002506] [10.3390/gels11090732]
Solution Calculators
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